@TheBHF Professor of Cardiac Physiology @OfficialUoM. Editor-in-Chief @JGenPhysiol. I research calcium signalling in the heart. (All views my own).

Manchester, England
Joined January 2018
“I greatly admire the journal’s style and editorial policy, as well as the dedication and enthusiasm of its editors.”— Dr. Yasushi Okamura (@yasushiokamura1). JGP, where editorial decisions are based purely on research quality: hubs.la/Q04d6bjy0
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New study by Burwood, Fridberger, et al. describes the distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane, neither of which is tonotopic in the apex. hubs.la/Q04d1ZDg0
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.@lfsantana68 lab @ucd_physiology shows that beat-locked cytosolic and mitochondrial ATP transients in sinoatrial node myocytes sort into high-gain, low-gain, or consumption-dominant modes aligned with superior–inferior vascular–mitochondrial gradients. hubs.la/Q0493Jm60
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“We have chosen to submit our work to the Journal of General Physiology because we are confident that the review process will be fair.”— Dr. Daniel Fitzsimons. Learn how scientists set the course 👉 hubs.la/Q045Dn0s0
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Yu Zhou, @LingleChris et al. ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent with a trinomial model of random mixing of β subunits. hubs.la/Q03VRCT-0
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Announcing the new SGP Rising Star Travel Awards for students and postdocs. The $500 awards can be used for meetings held up to 1 year from notification. Apply today! Deadline: 1 August 2025 sgpweb.org/awards/risings
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SGP is excited to invite proposals for thematic meetings for the years 2027 through 2029. These meetings will provide a platform for researchers to engage in meaningful discussions on critical topics within the field of physiology. Deadline: 1 June 2025 bit.ly/sgp_meeting_proposal.
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Read the full article in #PhysiologyNews: buff.ly/41IWSz4 🧵8/8
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Liu and Bezanilla @UChicago describe a voltage-gated sodium channel mutant that removes fast inactivation while the fast inactivation particle, the IFM motif, remains bound, indicating that fast inactivation requires additional conformational changes hubs.la/Q02ZJkSP0
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David Eisner retweeted
The Inaugural IUPS Beacon Meeting in Tutzing, Germany is going really well. It is fantastic to meet with colleagues across the Globe and to share learning. Last day tomorrow. A huge thank you to all involved. A couple of photos from the last few days. (Part 2)
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Great news! Congrats @JLCaldwellPhD. Also, Jess is on the job market and will be a great colleague. Plus her science is 🔥
Honored to be among these incredible ECIs as a recipient of the @GillKentucky cardiovascular research award. Looking forward to a great few days @ResearchKY
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Bonezzi, Tarchick, Moore, and Renna find that light drives the developmental progression of outer retinal function. hubs.la/Q02RDpG-0 📒 In our #Neuroscience collection: hubs.la/Q02RDr-T0 #SfN24
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Caldwell et al found atrial #ttubules can be restored post #HF, improving Ca handling & heart function. Learn about therapeutic insights for #atrial dysfunction in HF ahajrnls.org/3B7FeK7 @JLCaldwellPhD @KatDibb @DavidAEisner @awtrafford @TheCallumQuinn @G_Madders
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David Eisner retweeted
We are pleased to announce we are now open for the 2024 round of Julie Chan Prize (deadline - 15th October 2024) and the Early Faculty Award (deadline - 30th September 2024). Find out more here: iups.org/applications-2024-f…
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.@yaolisiman et al. @GlasscockLab @SMUBiology (hubs.la/Q02KqvnL0) reveal that, thought they only generate small currents in the sinoatrial node, Kv1.1 channels have a significant impact on cardiac pacemaking. Learn more in Research News: hubs.la/Q02KqCWh0
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AlphaFold predictions for GrTX-SIA binding to human Naᵥ1.6. @RitaCollaco, @FilipPetegem and Frank Bosmans @ugent_fge show that ω-Grammotoxin-SIA inhibits voltage-gated Na⁺ channel currents. hubs.la/Q02HM_m40 #IonChannels #VoltageGatedNaChannels
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🚨Abstracts deadline is 3 weeks away!🚨Submit by 1 August 2024 to be eligible for ✳️Travel Awards, ✳️Short Talks, and ✳️Poster Previews. Visit sgp2024.com to submit and register. #sgp2024meeting This exciting meeting brings together scientists and trainees to discuss cutting edge fundamental research relating to the functional conservation and molecular evolution of membrane-related molecules, such as ion channels, transporters, pores, and receptors.
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Image showing fusion pore flux, receptor dynamics, and diffusion. Jackson, Chiang, and Cheng @UWMadison show that fusion pore flux controls the rise-times of quantal synaptic responses. hubs.la/Q02BnqVm0 #ComputationalBiology #CellularPhysiology #IntercellularSignaling
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Deadline alert 🚨, less than one week left! Still spots remaining for this years GRS on Cardiac Regulatory Mechanisms. Application deadline March 17. Spread the word to all the ECI’s in your network! @GordonConf @Heart4Carolina
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🚨Register for the 77th @sgpweb Meeting🚨, ⭐️"Molecular Evolution in the Membrane: Ion Channels, Transporters, and Receptors"⭐️ Want to be considered for a short talk? Submit your abstract by 🗓️1 August! For more info and to register, visit sgp2024.com.
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