@Diekman_Lab
Joined February 2017
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  • Followers302
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2 papers out in December! Crazy that this is the normal rate for some labs. Michaela's on SIRT6 and DNA damage repair in chondrocytes (Aging, PMID: 38078876); Matt's on the "MagnaSquish" to test cartilage recovery during cyclic loading (J Biomechanics, PMID: 38128469).
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Richard Loeser and I reviewed the evolving understanding of aging in OA for the Osteoarthritis & Cartilage 30th anniversary issue. Available free for 50 days with this link: authors.elsevier.com/a/1iDfO… ; @UNCTARC @OACJournal
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Congrats to the newest doctor walking around Chapel Hill: Dr. Michaela Copp! First PhD defense from @Diekman_Lab and another awesome student from @jointbme.
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Paper out today in Aging Cell! Ever wonder how much DNA damage accumulates in chondrocytes during "normal" aging? We found out - a lot! Check out paper by @jointbme Diekman Lab grad student Michaela Copp and others from @UNCTARC here: doi.org/10.1111/acel.13698

Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes...

Chondrocytes accumulate a substantial burden of DNA damage during aging. As measured by the alkaline comet assay, there is a linear increase from 4th to 8th decade of life. The damage in tissue from...

onlinelibrary.wiley.com
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I really only use Twitter for work so 90% of you getting this tweet are already giving much of your energy and time towards MSK research. For the remaining 10%, consider joining me in supporting TARC! give.communityfunded.com/o/u…
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My first two PhD candidates! Both Matt and Michaela nailed their prelims this past month and fun to celebrate with the rest of the lab today. Fantastic first students and grateful they took the chance to join a new lab!
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We have a full-time position open at UNC - please join us! Likely ~75% research/25% lab management. Many techniques w/ focus on osteoarthritis: murine models, cell culture, genome editing. Experience a plus, but open to motivated folks w/o. Please RT. unc.peopleadmin.com/postings….
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Thanks to @MaerzAndBlue for engaging with the chat feature during our senescence symposium! The chat will stay up since not a "live session" so others can join in when they watch later. @Guilak_Lab @JHElisseeff @bxjohnstone cattendee.abstractsonline.co…
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Which one of these did Lou forget to include in his #ORS2021 talk? Fantastic insight into risk for ACL tears, a fedora, self-deprecating humor, Chuck Norris jokes, a cameo of his infamous Hawaiian shirt, Wookie noises? @defratelab cattendee.abstractsonline.co…
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Don't miss the ICORS College of FIORS-organized symposium at #ORS2021 'Cellular senescence in OA' on Monday at 8:15am PT. Three amazing talks! @Farsh_G @Guilak_Lab @JHElisseeff @Diekman_Lab
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Just watched Farsh nail his Kappa Delta talk summarizing work from @Guilak_Lab on biological joint resurfacing. So grateful that this project was my introduction to research! @TheBradEstes trained me and Frank Moutos always inspiring. Congrats on the award!
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Diekman lab graduate student Michaela Copp's paper, "The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence" is out in @OACJournal. Free download through Jan 23 at: authors.elsevier.com/a/1cB9-…. Fun working with @SchnabelLab on this!
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Check out our FASEB J paper describing senescence induction in cartilage explants from p16tdTom mice: fasebj.org/doi/10.1096/fj.20….
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Congrats to Matthew Rich for nailing his first ever talk at a scientific conference. Thanks to @BMESociety for providing such a great venue for young scientists. @UNCNCSUBME #bmes2018
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Our paper on the role of p16 in cartilage aging and osteoarthritis is now available (open access): onlinelibrary.wiley.com/doi/… Thanks to Aging Cell, co-authors, and funders! @AgingCell @CureArthritis @AFARorg @NIH @UNCTARC @UNCNCSUBME

Expression of p16INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing pro-inflammatory molecules known as the senescence-associat...

onlinelibrary.wiley.com
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Grateful to be working with both of these great foundations! xitter.cf/AFARorg/status/9304846…
AFAR@AFARorg14 Nov 2017
Proud to give the ’17 #Arthritis and #Aging #Research grant to Dr. Brian Diekman @UNCTARC @CureArthritis bit.ly/2zBSWn1
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