@Dorie00

Lead Scientist @HelmholtzMunich | Incoming group leader @IMPvienna Metabolism | Cancer Cachexia | Tissue clearing l Light-sheet imaging

Joined August 2010
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  • Following383
  • Followers421
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Incredibly happy to see our work published in @Nature today 🥹 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution nature.com/articles/s41586-0…

A deep-learning framework reveals whole-body perturbations at cell level

Nature - An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of...

nature.com
Ali Max Erturk
@erturklabMay 20
Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s41586-0… led by @Dorie00 & @yingchen733
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Marcus Goncalves
@MarcusDGonOct 9
First human trial of a noninvasive vagus-nerve device for cancer cachexia is enrolling at MD Anderson. Cachexia is neural signaling, not starvation — neuromodulation breaking that circuit is exactly the translation to watch after our sensory-neuron work. terasaki.org/institute/news/…

Terasaki Institute

Terasaki Institute for Biomedical Innovation:: Our Mission:: To invent and foster practical solutions that restore or enhances the health of individuals. Our Vision: The Terasaki Institute for...

terasaki.org
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Matthias Mann Lab@labs_mannOct 6
SPARCS: Deep Visual Proteomics-style laser microdissection meets genome-wide CRISPR screening. Find genes behind how cells look, isolate them, profile them by mass spec. Now in @CellCellPress! Tweetorial from @niklas_a_s follows🧵 doi.org/10.1016/j.cell.2026.…
Niklas Schmacke@niklas_a_sOct 6
Out now in @CellCellPress: ✨SPARCS✨, a platform for discovering the genes behind complex cellular phenotypes. SPARCS combines Al-powered image analysis with automated laser microdissection to precisely isolate cells from large mutant libraries. Paper and highlights👇(1/9)
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Niklas Schmacke@niklas_a_sOct 6
Out now in @CellCellPress: ✨SPARCS✨, a platform for discovering the genes behind complex cellular phenotypes. SPARCS combines Al-powered image analysis with automated laser microdissection to precisely isolate cells from large mutant libraries. Paper and highlights👇(1/9)
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nature
@NatureSep 29
A map of fats across the whole mouse brain reveals a spatial architecture that differs from that seen in gene-expression and protein atlases go.nature.com/3VQvDS7

Brain lipids are organized into zones — and reorganized during pregnancy

Nature - A map of fats across the whole mouse brain reveals a spatial architecture that differs from that seen in gene-expression and protein atlases.

nature.com
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Eric Topol
@EricTopolSep 23
The cardiovascular benefit from Ozempic in the large randomized trial was substantially not related to weight loss academic.oup.com/eurheartj/a…
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Christine Chio@ChiolaboratorySep 23
We found an adrenergic iron–MSRA axis that regulates methionine redox signaling and adipose browning. Disrupting MSRA preserved tissue mass and prolonged survival in tumor-bearing mice. Huge congrats to Jung Seung Nam, who led this work! nature.com/articles/s43018-0…

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

Nature Cancer - Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide...

nature.com
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💫 Thrilled to share that I’ll join @IMPvienna as a Group Leader in March 2027! My lab will study systemic disease across biological scales, from molecular mechanisms to organism-wide dynamics, with a focus on cancer cachexia. 👉🏻 imp.ac.at/groups/doris-kalte…

Doris Kaltenecker | Metabolism and cancer | Research Institute of Molecular Pathology (IMP)

How do molecular signals from individual organs shape whole-body physiology and disease? Uncovering how molecular signals propagate across the body to drive systemic disease and identify potential...

imp.ac.at
IMP@IMPviennaSep 21
She’s coming to the IMP, and she’s recruiting! 🔬 Doris Kaltenecker will join the IMP as a Group Leader in March 2027. Her lab will study organ-to-organ communication in systemic diseases, with a focus on cancer cachexia: imp.ac.at/news/article/doris…
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🎓 I’ll be recruiting PhD students through the Vienna BioCenter Autumn 2026 PhD call. If you’re interested in inter-organ communication, whole-body imaging or systemic disease biology, get in touch! training.vbc.ac.at/phd-progr…

PhD Program

Empowering Curious Researchers at the Vienna BioCenter PhD Program Are you a curious and motivated student looking to launch a successful scientific career? Look no further than the Vienna BioCenter...

training.vbc.ac.at
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IMP@IMPviennaSep 21
She’s coming to the IMP, and she’s recruiting! 🔬 Doris Kaltenecker will join the IMP as a Group Leader in March 2027. Her lab will study organ-to-organ communication in systemic diseases, with a focus on cancer cachexia: imp.ac.at/news/article/doris…
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Julian Grünewald@grunewajuSep 3
In 2025, one child got a CRISPR therapy made for him. Gene therapy's "moon landing". My #ERCStG ONE2MANY asks how editing scales from n=1 to many, in the heart: one edit for a group of mutations, AI-guided protein engineering & delivery. Thanks @ERC_Research & my fantastic team!
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Elizabeth McKenna@ElizSMcKennaSep 2
Now online in @CD_AACR: Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia - by @JulianoMacha17, Stephan Herzig, @BerrielDiaz and colleagues @HelmholtzMunich @helmholtz_diabc
Cancer Discovery@CD_AACRSep 2
Now online: Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia doi.org/10.1158/2159-8290.CD…
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Josh Huot, PhD, CSCS@JRHUOT_PhDAug 27
This newly published work in @NatureComms has been a long time coming! Huge collaborative effort with @A_bonetto_PhD and countless others, scratching the surface of the liver’s role in driving cancer-associated musculoskeletal wasting. nature.com/articles/s41467-0…

An FGF21-IGFBP1 tumor-liver relay drives musculoskeletal defects in colorectal cancer cachexia

Nature Communications - Colorectal cancer often causes cachexia, a wasting syndrome that weakens muscles and bones. Here, the authors show that a tumor-liver signaling relay driven by FGF21 and...

nature.com
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🔥 Check out our new study in Cancer Discovery @CD_AACR! We identify tumor-secreted ADAMTSL4 as a driver of cancer cachexia through local TGF-β1 activation. Congratulations to @JulianoMacha17 and the team! Happy to have contributed! aacrjournals.org/cancerdisco…

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia

Tumor-secreted ADAMTSL4 activates latent TGFβ1 at muscle cell surfaces, promoting muscle atrophy and fibrosis while also driving adipose tissue wasting, and represents a selective therapeutic target...

aacrjournals.org
Juliano Machado@JulianoMacha17Sep 1
🧬 Excited to share our new study, now published in Cancer Discovery! We identify tumor-secreted ADAMTSL4 as a previously unknown driver of cancer cachexia, promoting skeletal muscle and adipose tissue wasting. A thread on what we found 🧵👇
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Nature Metabolism
@NatMetabolismAug 21
Multi-organ proteomic atlas of obesity regression in male mice dlvr.it/TV6Q9Y

Multi-organ proteomic atlas of obesity regression in male mice

Nature Metabolism - A multi-organ proteomics resource of diet-induced obesity and its regression in male mice, spanning 15 organs and 4 timepoints, highlights systemic changes as well as...

nature.com
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Giulio Superti-Furga@giuliosfAug 14
We are opening the call for the first generation of Founding Principal Investigators of the Cori Institute in Graz. We are looking for scientists who want to understand metabolism as the fundamental organising logic of life.
🤖 Made with AI
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Philip Ruthig@PhilipRuthigAug 4
Got your own 3D data from clearing and light sheet imaging, but no idea how to tackle the analysis? We have just the solution for you in Munich: A two-day course on deep learning and VR-assisted segmentation, atlas registration, and so on! Take the course @erturklab
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Eric Topol
@EricTopolJul 30
Plasma proteins can predict metabolic liver disease (MASLD) up to 16 years ahead of its clinical appearance. One study after another showing the forecasting value of proteomics nature.com/articles/s43587-0…

Plasma proteomics framework predicts metabolic dysfunction-associated steatotic liver disease up to...

Nature Aging - Using plasma proteomics, Yu, Chen, Feng, Li et. al report a panel of five blood proteins that can predict future risk of metabolic dysfunction-associated steatotic liver disease...

nature.com
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Ali Max Erturk
@erturklabJul 30
SARS-CoV-2 spike protein accumulates & persists in the body for years👇🏻. We’re developing advanced imaging & AI to cure Long COVID & beyond👇🏻. Join us 🤗 nature.com/articles/s41586-0… cell.com/cell-host-microbe/f… biorxiv.org/content/10.64898… biorxiv.org/content/10.64898… biorxiv.org/content/10.1101/…
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📰 New Feature in @NaturePortfolio on #CancerCachexia The article explores recent advances in cachexia research, including work by @BerrielDiaz (IDC) on organ crosstalk and the role of liver-derived signals in metabolic regulation. ➡️ nature.com/articles/d41586-0…
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Maria Rohm@RohmMariaJul 16
💫 I'm excited to share our new Comment @NatureRevEndo, calling to reframe #cancercachexia from malnutrition to treatable metabolic disease: nature.com/articles/s41574-0…
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