Professor, SLS, JNU
Joined September 2014
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Great to see our work on mechanobiology of recurrent GBM featured @iitbombay. Our collaborative study with @abhijit_MLab highlighted how brain like mechanical environment shape tumour aggressiveness & reveal therapeutic vulnerabilities. Do read! @ANRFIndia @A_Acharekar_KI
In a series of studies from the mechanobiology laboratory of Prof. Abhijit Majumder at IIT Bombay, scientists mimick the brain’s softness in the laboratory to uncover why brain Cancer relapses and what standard lab dishes had been hiding all along.
iitb.ac.in/research-highligh…
@abhijit_MLab
Delighted to see our work on mechanobiology of GBM highlighted. Thanks to the wonderful collaboration with @abhijit_MLab revealing how the brain-like mechanical microenvironment can uncover aggressive phenotypes & therapeutic vulnerabilities. Do read! @ANRFIndia @A_Acharekar_KI
Why are plastic petri dishes failing brain cancer research?
Scientists from @iitbombay and @ACTREC_TMC have discovered that long non-coding RNAs act as sensors of physical forces in glioblastoma (brain cancer). Studies led by Prof. Abhijit Majumder and Prof. Shilpee Dutt using lab-cultured glioblastoma reveal crucial distinctions between parent and relapsed cells that are not visible on plastic surfaces.
To deep dive, tap
researchmatters.in/news/hard…
@IndiaDST | @DBTIndia | @ANRFIndia | @serbonline | @DAEIndia | @CRI_ACTREC | @gmanjeera | @DuttShilpee | @abhijit_MLab
#glioblastome #organiods #cancerresearch #cancer #science #scienceeducation #scicomm #Indianscience
Thank you, IBI, for featuring the excellent work of ANRF-NPDF fellow, Dr Monikongkona Boruah, from our lab. Congratulations, Moni! @moni_boruah @ANRFIndia
🔬✨ #FluorescenceFriday
IBI is delighted to showcase this week's highlight from Prof. @DuttShilpee 's Lab, School of Life Sciences, JNU, in collaboration with CCRF, @aiims_newdelhi
🖼️Image Title: Glioblastoma Tumoroid
Patient-derived glioblastoma tumoroids closely mimic 1/4
Excited! Our latest paper is online in npj Precision Oncology! @Nature_NPJ
Great work by PhD student @Archisman_bnj identifying #BEND4 as novel single-gene prognostic marker and therapeutic target in #AML
Thanks co-authors @ANRFIndia @DBTIndia @ACTREC_TMC
doi.org/10.1038/s41698-026-0…
Thrilled to share that our paper in Neuro-Oncology @NeuroOnc, uncovering the molecular switch driving GBM senescence reversal, is among the most cited recent publications in the field. The science speaks for itself! Congratulations @MadhuraKetkar and all the co-authors
✨ Our article from my PhD work in @NeuroOnc is the most cited recent publication in the journal- 10 times more cited than average. ✨
Thanks to @DuttShilpee and all the co-authors for their contribution!
Shilpee Dutt retweeted
@ArpitaGhosh1392 and I will give a joint talk. While I will be talking about our background journey that started with @DuttShilpee lab, Arpita will tell the story of journey forward.
The last date for applying to a PhD program at SLS, JNU is tomorrow. Do apply if you are interested in cutting-edge, multidisciplinary research!
We will be happy to host NPDF at Shilpee Lab (SLS, JNU). Visit our lab website (jnu.ac.in/content/shilpeedut…) for research interests and recent publications.
Please write to me with your CV and research interests
Thank you @SciSoup for highlighting our findings.
Excellent work by my PhD student, Tejashree, now in Oncogene
@teju1090 @MadhuraKetkar @Archisman_bnj @nileshgardi2688 @biopatrika @Ratnesh_thakur @oncogenejournal
Scientists Uncover Unusual Cell Division Behind Glioblastoma’s Deadly Comeback
Read more:
🔗scisoup.org/article/2025/sci…
@DuttShilpee @JNU_official_50 @ACTREC_TMC @CRI_ACTREC @Bajaj_RCB @Ratnesh_thakur @SciComm_India @indianscinews #scicomm #scisoup
Take a look at our latest article! Superb findings by PhD student Tejashree (@teju1090). Residual #GBM cells divide via #Neosis!
Thank you @ANRFIndia and co-authors @Archisman_bnj @MadhuraKetkar @nileshgardi2688
nature.com/articles/s41388-0…
Shilpee Dutt retweeted
Apply for a Hands-on #Workshop on Chromatin Modification, Epigenetics and Genetic Regulation organized by the School of Life Sciences, JNU!
#DBT #BUILDER
🔗docs.google.com/forms/d/e/1F…
@DrJitendraSingh @rajesh_gokhale @JNU_official_50
Thank you @DBTIndia for highlighting our study. Indeed, inhibition of PERK mediated UPR provides a much-needed seno-therapeutic option in the most aggressive brain tumor (glioblastoma). pubmed.ncbi.nlm.nih.gov/3902… @MadhuraKetkar @CRI_ACTREC @ACTREC_TMC @amtdutt
Research from the lab of @DuttShilpee aims to delineate the #TIS reversal mechanism in glioblastoma #GBM recurrence. The study provide evidence of a novel senolytic drug offering a new seno-therapeutic option for eliminating residual GBM & preventing recurrence.
@DrJitendraSingh
Happy to share our latest paper in @CMLSjournal. This impressive study, PhD work of @debashmitasark5 provides mechanistic details of GCN5 function at DSBs. Thanks @amartya_acad @shainamandi. Thanks @DBTIndia @ANRFIndia @ACTREC_TMC @CRI_ACTREC for support
rdcu.be/dZx7e
Congratulations to the brilliant PhD student, @MadhuraKetkar for this excellent study identifying molecular switch for TIS reversal in GBM. Paper's now online @NeuroOnc. Thank you co-authors, @DBTIndia, @serbonline, @ACTREC_TMC, @CRI_ACTREC for support
academic.oup.com/neuro-oncol…
Shilpee Dutt retweeted
Students, here's a glimpse inside an academic research lab! Monthly grind, celebrations, Eureka moments & what it takes to thrive in this dynamic field: an abridged decade-long compilation from our monthly newsletter combined with Shilpee Lab. amitduttlab.com/newsletter
Shilpee Dutt retweeted
The Tail & Tango of Cancer genome-- we developed a tool “DOME” to tame the tail of rare mutations; in another study, we describe the first chromosomal tango “Chr 11/5 fusion” in oral cancer genome. Thanks to @ACTREC_TMC,@CRI_ACTREC,@DBTIndia,@India_Alliance,@DAEIndia,@UnivofDelhi
ALT https://academic.oup.com/narcancer/article/6/1/zcae010/7626437
ALT https://www.nature.com/articles/s41698-024-00555-4
Shilpee Dutt retweeted
Pleased to share the dev' of DOME by @desaisanket12 and team! Thanks @NAR_Cancer_EIC & @ACTREC_TMC. This powerful comput'l framework identifies potential driver mutations, advanc'g personalized cancer therapy with emphas' on VUS ! @CRI_ACTREC @UnivofDelhi academic.oup.com/narcancer/a…
Shilpee Dutt retweeted
UBE3C-LRP5, novel oncogenic fusion-transcript in oral cancer @ 5.3% in Indian & 1.2% TCGA patients. Kudos to @dbhaskarjnv & Ashwin Butle in collab with Dr. Sudhir Nair! Pyrv' pamoate, an FDA approved dewormer, targets this fusion. A potential game-changer! nature.com/articles/s41698-0…
Shilpee Dutt retweeted
Our Friday evening was so much fun! This was a farewell night out for @DuttShilpee who is soon leaving us! We celebrated her achievements - also was Women's Day 😍🎉 Best wishes Shilpee for your future innings! We will miss you a lot at CRI
@biopatrika
Shilpee Dutt retweeted
Saket Mishra @svm2607, Shilpee Dutt @duttshilpee, et al. @CRI_ACTREC identify the GCN5–DNA-PKcs–TOP2B transcriptional regulatory axis underlying anthracycline resistance in acute myeloid leukemia, pinpointing DNA-PKcs as a potential therapeutic target.
journals.biologists.com/jcs/…
ALT Graphs showing that mitoxantrone induced G2/M- and S-phase cell cycle arrest only occurred in sensitive cells, but not in resistant cells.