@DziembowskiLab

Laboratory of RNA Biology - ERA Chairs Group at @IIMCB_Poland, headed by @AndrzejDziembo1 #MOSaIC #ERAChairs #DziembowskiLab

 Warsaw, Poland
iimcb.gov.pl/en/research/41-laboratory-of-rna-biology-era-chairs-group
Joined December 2022
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  • Following59
  • Followers203
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Our recent study published in @Nature uncovers #TENT5A-mediated re-adenylation as a crucial factor in stabilizing therapeutic #mRNA and enhancing its immunogenicity in #SARS_CoV_2 #vaccines.
Andrzej Dziembowski@AndrzejDziembo217 Apr 2025
Happy to share with you our new @Nature story about the crucial role of TENT5A-mediated re-adenylation of mRNA COVID-19 vaccines in boosting their efficacy. We also show how important macrophages are in producing the antigen following vaccination. nature.com/articles/s41586-0… @
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📢The 2024 Parnas Award 🏆– the top distinction of the Polish Biochemical Society – goes to the IIMCB team led by Prof. Andrzej Dziembowski @DziembowskiLab for advancing our understanding of the molecular mechanisms of infertility.🧬 🔗 Read more: tinyurl.com/Parnas-Award-IIM…
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Scientists from the IIMCB described a new mechanism that improves the efficiency of mRNA-based therapies. The research findings will facilitate the development of novel therapeutics against cancers and infectious diseases. #NaturePublication #mRNA #FunduszeUE @REA_research
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DziembowskiLab retweeted
Pawel Krawczyk@pakraw17 Apr 2025
🎉 Incredibly proud to share my first-author paper in @Nature! Heartfelt thanks to my mentor @AndrzejDziembo1 and the brilliant team at @DziembowskiLab. More details in the 🧵below ⬇️ nature.com/articles/s41586-0…

Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines

Nature - Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA...

nature.com
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During the International Advisory Board meeting, we once again had the opportunity to celebrate a historic milestone – the first PhD defense at IIMCB. Michał Brouze, PhD, officially received his biretta and doctoral diploma. #PhD #Graduation #IIMCB @DziembowskiLab
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The latest achievement from the lab, Ninetails, published at @NatureComms. This is the first fully #bioinformatics paper from the lab. Huge congrats to @nemithesaura. #RNA #nanopore #polyA #nonadenosines
Natalia Gumińska@nemitheasura19 Mar 2025
I am happy to share our most recent results published in Nature Communications. Ninetails - a pipeline for detection of non-adenosines in poly(A) tails of Oxford Nanopore Direct RNA Sequencing reads. Many thanks to LBR lab members for this work. nature.com/articles/s41467-0…

Direct profiling of non-adenosines in poly(A) tails of endogenous and therapeutic mRNAs with...

Nature Communications - Ninetails, a neural network that uses Nanopore Direct RNA sequencing data to identify non-A residues in mRNA poly(A) tails is presented. Particularly non-A of therapeutic,...

nature.com
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#Ninetails outperforms existing approaches as it avoids amplification artifacts and provides single-read (@nanopore) resolution of #polyA tail composition. It classifies non-adenosine residues with >93% accuracy and ~98% specificity.
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#Ninetails is freely available for researchers worldwide (github.com/LRB-IIMCB/ninetai…), opening new avenues to explore #RNA biology.

GitHub - LRB-IIMCB/ninetails: An R package for finding non-adenosine residues in poly(A) tails of...

An R package for finding non-adenosine residues in poly(A) tails of ONT direct RNA sequencing reads - LRB-IIMCB/ninetails

github.com
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Our researchers secured MAESTRO 16 & SONATA BIS 14 grants from @NCN_PL ! 🎉 🔬 TENT5A & Hormonal Regulation – Prof. Dziembowski (5.97M PLN) 🔬HAV Gene Expression – Dr. Bresson (4.78M PLN) Congrats to the teams! 👏 #IIMCB #NCN #MolecularBiology #Endocrinology #HepatitisA
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📢 Prof. @AndrzejDziembo1 elected to the @RNASociety Board of Directors! 🎉 This global organization unites over 2,500 members dedicated to advancing RNA research and education 🌐 👉Read the story: tinyurl.com/RNASocietyDziemb…
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Jutro 6.10: 1. Ogłoszenie Nagrody Nobla w Medycynie i Fizjologii 2. Najlepsi badacze z grantami ERC reprezentujący zainteresowanych rozwojem nauki w Polsce zapraszają na konferencję prasową👇 Co takiego mają do powiedzenia politykom i społeczeństwu? Stay tuned #NCNtoTlen
Agnieszka Chacińska@A_Chacinska4 Oct 2024
Kolektyw Ambitnych Badaczy dziala! Drodzy dziennikarze przybywajcie - bo utoniemy @AlicjaGardulska @annawitten @boleslawbreczko
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"Stan nauki w Polsce jest kwestią racji stanu i to od niego zależy przyszłość naszego państwa, nie możemy pozwolić, aby nauka i szkolnictwo wyższe było drugorzędnym obszarem polityki publicznej państwa."
Forum Akademickie@ForumAkad3 Oct 2024
Dla wielu z nas finansowanie projektów przez @NCN_PL było kluczowym elementem pozwalającym w ogóle prowadzić przełomowe badania naukowe – piszą w liście do @PremierRP @donaldtusk i @wieczorekdarek laureaci Nagród @Polityka_pl. #budżet #NCN #granty forumakademickie.pl/sprawy-n…
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Replying to @AndrzejDziembo1
@AndrzejDziembo1 & his group plan to investigate ways to increase the stability of mRNA, allowing for their deeper integration into therapeutic medicine. Join @DziembowskiLab. Apply to Warsaw-4-PhD: bit.ly/IIMCB_Warsaw4PhD
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Following up on our paper about AbiK and Abi-P2, we now present an in-depth characterization of the third Abi polymerase, AbiA, performed in collaboration with @hauryliuk lab and @DziembowskiLab. academic.oup.com/nar/advance…

Structure-functional characterization of Lactococcus AbiA phage defense system

Abstract. Bacterial reverse transcriptases (RTs) are a large and diverse enzyme family. AbiA, AbiK and Abi-P2 are abortive infection system (Abi) RTs that

academic.oup.com
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Join us and contribute to the long-term development of all core facilities at the IIMCB. As a Core Facility Technology Manager, you will gain expertise and work in close cooperation with @VIBLifeSciences. Apply now: bit.ly/48pbjZ6
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Replying to @DziembowskiLab
@DziembowskiLab is inviting applications for a Postdoctoral Researcher and a Research Assistant. Apply now: bit.ly/3Scq3nK
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