Eleni Jaecklein (@EJaecklein) profile picture

Eleni Jaecklein

@EJaecklein
Joined September 2018
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  • Following115
  • Followers74
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Eleni Jaecklein retweeted
Sassetti Lab (@SassettiLab) profile picture
Sassetti Lab@SassettiLab8 Dec 2021
Happy to share the latest from Mike Kiritsy's thesis work - a comparative CRISPR screen identifies a new link between metabolism in immunity, and begins to differentiate the diverse effects of IFNg: elifesciences.org/articles/6…
Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

Complex I of the mitochondrial respiratory chain is necessary for interferon gamma-mediated responses in antigen-presenting cells and is required for CD4+ T cell activation.

elifesciences.org
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Eleni Jaecklein retweeted
Andrew Olive (@andolive85) profile picture
Andrew Olive@andolive8523 Nov 2020
I’m REALLY excited for our new study to be posted! In collaboration with @SassettiLab this story pushed us in lots of new directions leading us to uncover a key role for Mitochondrial respiration in IFN-gamma responses in macrophages! A thread:
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint23 Nov 2020
Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells biorxiv.org/cgi/content/shor… #bioRxiv
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If you are interested in interactions between host immunity and mycobacterial respiration, check out the preprint of my first, (co)first-author paper! Big thanks to everyone involved! @SassettiLab @andolive85
Andrew Olive (@andolive85) profile pictureAndrew Olive@andolive8522 Aug 2020
Another interesting one from the @SassettiLab! Read more for some cool insights into host immunity, pathogen respiration, and low pH! Some great work by @EJaecklein!!! biorxiv.org/content/10.1101/…
Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase

In order to sustain a persistent infection, Mycobacterium tuberculosis ( Mtb ) must adapt to a changing environment that is shaped by the developing immune response. This necessity to adapt is...

biorxiv.org
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Eleni Jaecklein retweeted
Andrew Olive (@andolive85) profile picture
Andrew Olive@andolive8513 Aug 2020
I'm so excited for the first research article from my group to be posted! There is CRISPR, RNAseq AND T cells! Something for everyone! It was an amazing effort by @LaurisaAnkley and Mike Kiritsy in collaboration with @FitzgeraldKate. Thought I'd do a quick thread to explain: 1/11
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint13 Aug 2020
A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation biorxiv.org/cgi/content/shor… #bioRxiv
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Thrilled to share our @SassettiLab research investigating how Mycobacterium tuberculosis survives during antibiotic treatment published in @mSystemsJ! msystems.asm.org/content/5/4…
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Replying to @ryan_richards33
@ryan_richards33 and @TheLeeLab found that drug combinations comprised of two cell death targeting drugs are enriched for antagonism and “single agent dominance". nature.com/articles/s41589-0…
Drug antagonism and single-agent dominance result from differences in death kinetics

Drug antagonism and single-agent dominance result from differences in death kinetics

Nature Chemical Biology - Drug combinations consisting of two cell death-targeting drugs are enriched for antagonism and ‘single-agent dominance’, where the faster-acting drug...

nature.com
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Eleni Jaecklein retweeted
Michael J. Lee (@TheLeeLab) profile picture
Michael J. Lee@TheLeeLab31 Mar 2020
Our lab just posted a new preprint which shows how ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells. Congrats @CruzgordilloP @meganhoneywell and the rest of the team! biorxiv.org/content/10.1101/…
Image from Michael J. Lee (@TheLeeLab)
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Eleni Jaecklein retweeted
Aditya Bandekar (@bandekarac) profile picture
Aditya Bandekar@bandekarac11 Feb 2020
New preprint from the @SassettiLab! A fun collaboration with Sishir Subedi and Tom Ioerger, our friends from TexasA&M. Hope you all have an enjoyable read! biorxiv.org/content/10.1101/… A thread of some cool things we found....
Cell cycle-associated expression patterns predict gene function in mycobacteria

Cell cycle-associated expression patterns predict gene function in mycobacteria

While the major events in prokaryotic cell cycle progression are likely to be coordinated with transcriptional and metabolic changes, these processes remain poorly characterized. Unlike many rapidl...

biorxiv.org
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Eleni Jaecklein retweeted
mBio (@mbiojournal) profile picture
mBio@mbiojournal3 Dec 2019
Functionally overlapping variants control tuberculosis susceptibility in collaborative cross mice @ASMicrobiology skyw.io/mWeI4l
Image from mBio (@mbiojournal)
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Eleni Jaecklein retweeted
Tim Skellett (@Gurdur) profile picture
Tim Skellett@Gurdur23 Nov 2019
An aerial view of a sheepdog as it demonstrates fluid mechanics, and it also shows a sheep is a particle, while a flock is a wave.
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HIV, Ebola, and Zika are deadly, intricate viruses. Structural biologist David Goodsell helps communicate about them with precision through his watercolor paintings. fcld.ly/dbnaccs
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Il topo vitruviano-@SassettiLab
Image from Eleni Jaecklein (@EJaecklein)
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Excited to share our paper on glpK mutations reducing treatment efficacy of tuberculosis out in @mbiojournal! @SassettiLab Such a pleasure to work with #SeungHunBaek and all our coauthors! Including @TassieClare @megan_b_murray 1/3 mbio.asm.org/content/10/4/e0…
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Eleni Jaecklein retweeted
Sassetti Lab (@SassettiLab) profile picture
Sassetti Lab@SassettiLab12 Dec 2018
A great collaboration with the Sacchettini lab: sacclab.com. ncbi.nlm.nih.gov/pubmed/3031…
Image from Sassetti Lab (@SassettiLab)
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Eleni Jaecklein retweeted
Newsweek (@Newsweek) profile picture
Newsweek
@Newsweek7 Nov 2018
NEW: Alexandria Ocasio-Cortez wins election to the House in New York's 14th Congressional District, becoming the youngest woman ever elected to Congress bit.ly/2Dqk22J
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Eleni Jaecklein retweeted
Samantha Nelson (@SamiGram13) profile picture
Samantha Nelson@SamiGram1317 Oct 2018
Hot off the press from our lab @SassettiLab. Congrats @embely! TCA cycle carbon flux regulation is important for survival under hypoxic conditions. Loss of Mt-Pat or inhibition of MDH activity = reduced viability and increased carbon flux through the oxidative branch of TCA.
dr emily rittershaus (@embely) profile picturedr emily rittershaus@embely16 Oct 2018
Wow so cool 😎 “A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis” cell.com/cell-chemical-biolo…
A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium...

A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium...

Bacterial infections can persist because non-replicating organisms are killed slowly by antibiotics. This work describes a metabolic change that is essential for the survival of non-replicating...

cell.com
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Cell Suicide - An Essential Part Of Life: 📌Apoptosis (programmed cell death) of a T685A human melanoma cancer cell 📌Shows the orchestrated collapse of a cell characterized by membrane blebbing, cell shrinkage, chromatin condensation @NanoLiveLtd #Science #Apoptosis
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Eleni Jaecklein retweeted
Sassetti Lab (@SassettiLab) profile picture
Sassetti Lab@SassettiLab10 Sep 2018
Don't get us wrong, we love C57BL/6, but mouse wrangler @TassieClare has some thoughts on introducing genetic diversity into our work:
Image from Sassetti Lab (@SassettiLab)
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