DNA samples and extensive health records of 20% of the adult population of Estonia (212,000 individuals), applied in 100s of international research projects.
Estonia
Joined April 2017
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Using EstBB data Maris Alver’s team examine how genetics & treatment relate to healthcare use in psychotic disorders & bipolar disorder. While genetic liability was reflected in contact frequency, treatment was the strongest predictor of rehospitalisation.
medrxiv.org/content/10.64898…
Estonian Biobank retweeted
Research Briefing: An investigation of the Estonian Biobank and the UK Biobank has identified more than 88,000 associations between more than 8,000 genomic regions and metabolic traits.
go.nature.com/4dIGu7v
Estonian Biobank retweeted
✨ A new star allele was born! Excited to share our first in vivo pharmacokinetic recall study involving 114 participants from @ESTbiobank with previously uncharacterised variants in CYP2C19 and CYP2D6:
nature.com/articles/s41525-0… #Pharmacogenomics #PharmVar #ClinPGx
Estonian Biobank retweeted
Mõnikord peetakse geenivaramut ekslikult tervishoiuasutuseks. Millist rolli täidab geenivaramu tegelikult Eesti tervishoiu innovatsioonis? epl.delfi.ee/artikkel/120413…
Estonian Biobank retweeted
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
🔗biorxiv.org/content/10.1101/…
Estonian Biobank retweeted
Great news! Our Associate Professor of Neuropsychiatric Genomics, Kelli Lehto, has been selected to receive the European Research Council grant!
💐Congrats on that outstanding achievement!
👉ut.ee/en/news/erc-grant-help…
Estonian Biobank retweeted
A study of genetic effects on adverse events from antidepressants in the Estonian Biobank: CYP2C19 and polygenic risk scores.
@ESTbiobank @MilaniLili @HannaKariis
nature.com/articles/s41431-0…
Estonian Biobank retweeted
🚨 Our parent-of-origin study is out in @Nature ! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗nature.com/articles/s41586-0…
Highlights below!
Estonian Biobank retweeted
🎉 Excited to share that our latest paper is now published!
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @ESTbiobank, leveraging data from questionnaires and clinical notes using NLP.
shorturl.at/3tAkg
Estonian Biobank retweeted
A study in @NatureMedicine provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. go.nature.com/3YldiLt 🔒
ALT This is figure 4, which gives an overview of loci associated with the studied female reproductive health traits.
Estonian Biobank retweeted
Excited to share our recently published overview of the @ESTbiobank 🧬
We highlight the unique features of the biobank and the conducted scientific research, including the many recall studies that have been carried out over the years:
nature.com/articles/s41467-0…
Estonian Biobank retweeted
💡Can we use real world drug purchase data to study the genetics of medication dosing?
We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵
📄 doi.org/10.1101/2025.04.01.2…
Tremendous work by @PujolGualdo @TLaisk and team! 👏🏼👏🏼👏🏼
A new study provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. @genomicstartu #ReproductiveHealth
nature.com/articles/s41591-0…
Estonian Biobank retweeted
New paper out: microbiome and causal inference! Let us tell you a bit more:
Estonian Biobank retweeted
🧬🧠Recent research @ESTbiobank @genomicstartu revealed that high genetic liability to #ADHD raises risks for 80 health conditions like #COPD (+70%), #obesity (+60%) & type 2 diabetes #T2D (+45%) - even without an ADHD diagnosis. Better screening & awareness for adults is needed!
Estonian Biobank retweeted
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @CellCellPress.
cell.com/cell/fulltext/S0092…
A thread 🧵:
Estonian Biobank retweeted
Delighted to accompany President Dr. @MMuizzu on his visit to the @unitartu Institute of Molecular and Cell Biology, today.
We were warmly welcomed by Professor @MilaniLili, Head of Estonian Biobank & Professor of Pharmacogenomics and had an inspiring exchange on advancing digital health and genetic research.
@ESTbiobank @genomicstartu
Estonian Biobank retweeted
We are delighted to contribute with Estonian Biobank data to this massive collaboration 🎉 So glad to see this work published!
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @CellCellPress.
cell.com/cell/fulltext/S0092…
A thread 🧵:
Estonian Biobank retweeted
This is what happens when you return research results to biobank participants:
✅The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅"Estonian Biobank" among Top10 search terms.
Huge thanks to all at @ESTbiobank & @genomicstartu ✨
Estonian Biobank retweeted
🦠 Excited to share our new collection of human gut #archaea species! 🎉
🇪🇪From @ESTbiobank, we present a dataset of 144 strains across 21 species, including 9 entirely new species!
A thread 🧵
#MAG #EstMB #TartuMicrobiome #microbiome #humangut
