@EdgarLaurienne
Joined October 2019
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A new study from @EdgarLaurienne & @NavAkbar from @Choudhury_Lab shows that high levels of extracellular glucose induce trained immunity in macrophages, promoting a pro-atherosclerotic phenotype that persists even after normalization of glucose levels nature.com/articles/s41569-0…
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Laurienne Edgar retweeted
Circulation@CircAHA15 Jul 2021
Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after glucose normalization. Why glucose control alone may not be enough for #ASCVD risk reduction in #diabetes ow.ly/BXt750FvJMu #AHAJournals
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After 7 years of hard work, Edgar & Akbar et al. is finally out for all to enjoy 🤓 so many congratulations & thanks to everyone involved, especially @NavAkbar, @Choudhury_Lab, @TheBHF and @novonordiskfond ahajournals.org/doi/abs/10.1…

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atheroscl...

Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages, promoting persistent...

ahajournals.org
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Replying to @EdgarLaurienne @RDMOxford @TheBHF @UniofOxford @novonordiskfond @ImmunoMet @CircAHA
Or, ‘higher blood sugar levels reprogrammed stem cells’ if you want the condensed version of this magnum opus - congrats all 😊 inews.co.uk/news/health/high…

High blood-sugar levels 'reprogramme' stem cells leading to greater risk of heart attacks

Researchers found diabetes causes 'long-term changes to the immune system' which can in turn increase the chances of heart and circulatory disease

inews.co.uk
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