Ellen Tenstad

ALT (1) Researchers submerge cells in a hydrogel solution containing sodium acrylate. (2) Water-absorbing polymers of sodium polyacrylate build up to form a gel. (3) Water added to the gel occupies space in between the polymers, causing the gel and cells to swell. (4) Cells are viewed with the naked eye using a stain for protein-rich components.

ALT Supplementary Figure S15. IL-1 receptor antagonist restricts healthy and malignant myeloproliferation. Illustration of the proposed model. Under steady-state, hematopoietic stem and progenitor cell (progenitor) differentiation is controlled by balanced IL-1β/IL-1rn, resulting in low NFκB activation (left). Low IL-1rn contributes to biased IL-1β-induced myelopoiesis dependent on NFκB activation in healthy conditions and preleukemic disease, is a prognostic marker for AML patients, and provides a new rationale for IL-1β blockade therapeutic potential (right). MSC, mesenchymal stromal cells.