@Elliott_Lab_Ox

Latest news from the lab of Paul Elliott. Ubiquitin | Structural biology | Biochemistry. Views our own.

 University of Oxford, UK
elliottlab.web.ox.ac.uk
Joined August 2022
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  • Following72
  • Followers263
2Media
Really honoured to have received this funding from CRUK to support the Lab – it enables us to venture into new and exciting directions investigating how highly aneuploid cancer cells exploit certain ubiquitin ligases for their survival.
Science and Innovation at Cancer Research UK@CRUKresearch20 Aug 2024
[1/3] Meet the latest #CRUKFunded researchers awarded Programme Foundation Awards by our #DiscoveryResearch Committee. Read about their programmes below & learn more about our scheme here: bit.ly/4bDg2b7
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We are hiring! Two structural biology/biochemistry postdoc positions are available in our lab - come and join a lively Team in the thriving city of Oxford! Deadline 4th October 2024. Further details are here: my.corehr.com/pls/uoxrecruit…
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Having a great time talking science in the sun ☀️
Fusion Conferences@Fusion_Conf8 Jul 2024
✨What a group!✨Some fantastic research shared so far and there’s still much more to come. We’re looking forward to some down time in the Portuguese sunshine to rest and reset for this afternoons session #Ubiq24
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We’re hearing about UBIQUITIN SIGNALLING IN CELL SURVIVAL AND CELL DEATH from @Elliott_Lab_Ox #Ubiq24
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#TECPR1 replaces #ATG16 as receptor of the ATG5/ATG12 E3 ligase to conjugate #LC3 to damaged vesicles displaying sphingomyelin on their cytosolic face. New LC3 ligase for #autophagy and first ever receptor for sphingomyelin! Discovered by K.Boyle... embopress.org/doi/full/10.15…
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We are excited to announce @Biochem_Journal, @StablixInc, @ubiquigent, @BiosynthGroup, @entactbio and @UbiQbio are all sponsors of our DUBS 2023 scientific meeting. Learn about the variety of sponsorship packages available here: ow.ly/jbz350ONUo1
A Biochemical Society Scientific Meeting. Deubiquitylases and Ubl-proteases, 19-21 June 2023, The University of Edinburgh, UK. Register online: bit.ly/DUBS-2023

ALT A Biochemical Society Scientific Meeting. Deubiquitylases and Ubl-proteases, 19-21 June 2023, The University of Edinburgh, UK. Register online: bit.ly/DUBS-2023

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It's been great to have you join us for these last few weeks, Yanis, and glad you saw Oxford in so much sunshine ☀️
SOAP@LabSoap6 Jun 2023
Thanks @Elliott_Lab_Ox for hosting @mace_yanis from @LabSoap @nbidere - grateful to @ProteoCure @NantesUniv #DoctoralSchool @laliguecancer
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Congratulations to the new Dr Schönewolff @EguesMaribel - first DPhil of the Lab! Thanks to examiners Yogesh & John for great scientific discussions! @YKulathu @ERADLab
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Great Department Away Day @BiochemOxford last week full of interesting talks rounded off brilliantly by @larissadi2
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A great PhD opportunity in structural biology!
Matt Higgins@ParasiteMatt14 Feb 2023
We have a place available on our Wellcome Cellular Structural Biology program for 2023 entry and are accepting applications. It is a fantastic program. Encourage your students to apply!
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Elliott Lab retweeted
Larissa Di@larissadi210 Feb 2023
Excited to share our most recent work on the giant ubiquitin ligase #BIRC6 out now in @ScienceMagazine science.org/doi/10.1126/scie…!   Thread below 🧵 (1/7)
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Congratulations also to @fisherlab1 (@moritzhunkeler) and @clausen_lab (@julianehrmann) for great BIRC6 publications too! science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
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Elliott Lab retweeted
Rob Klose@RobKlose9 Feb 2023
Amazing work from our colleagues @Elliott_Lab_Ox in Science today. Congratulations, what a monster of a structure and lovely biochemistry as well! science.org/doi/10.1126/scie…

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase...

Structures of BIRC6 reveal its ubiquitin ligase activity, caspase inhibition mechanisms, and regulation by SMAC.

science.org
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Delighted to share our latest structural & biochemical work uncovering how the gigantic #ubiquitin ligase, BIRC6, regulates cell death - out now in @ScienceMagazine! science.org/doi/10.1126/scie… @BiochemOxford @larissadi2 @CaraEllison8 @adanpinto @BenedicktKessler

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase...

Structures of BIRC6 reveal its ubiquitin ligase activity, caspase inhibition mechanisms, and regulation by SMAC.

science.org
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Great to show you around the @BiochemOxford Ivan and to chat about ubiquitin on a sunny day in Oxford!
Ivan Đikić@iDikic211 Oct 2022
Five miles #walkingmeeting with Paul Elliot from @BiochemOxford talking about structures of BIRC6 ubiquitin ligase complex that ubiquitinates #Caspases and is supressed by SMAC. 😊 @UniofOxford @Dunn_School @IBC2_GU @RMU_EMTHERA biorxiv.org/content/10.1101/…
Thanks for attending the very first Ubiquitomics Conference @UniofOxford! The presentations were excellent and generated very exciting discussions. A big shout out to all @KebleOxford for having us. Until the next one!
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So excited to share latest work from @Elliott_Lab_Ox! We find BIRC6, an enormous #ubiquitin IAP ligase, directly inhibits caspases and we show how this is blocked by SMAC. biorxiv.org/content/10.1101/… Plus great mass spec collab with @adanpinto @kesslerlabox

Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC

Apoptosis, a form of genetically programmed cell death, can be triggered by either internal or external signals ultimately activating caspases, a family of proteases[1][1]. Certain members of the...

biorxiv.org
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What a week for BIRC6! Great complementary work by @clausen_lab biorxiv.org/content/10.1101/… and @fischerlab1 biorxiv.org/content/10.1101/… Happy reading everyone!
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Delighted to share our latest work where we reveal how a gigantic ubiquitin ligase prevents cell death and is itself inhibited biorxiv.org/content/10.1101/…

Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC

Apoptosis, a form of genetically programmed cell death, can be triggered by either internal or external signals ultimately activating caspases, a family of proteases[1][1]. Certain members of the...

biorxiv.org
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And here's Day 2. Spread the word! Register here today: oxforduniversitystores.co.uk…
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