I almost forgot this account...
Whether or not you're still using it, here's an update: my paper on M-matrix (w/ @mwpen) is published! Again, many thanks to @ArlinStoltzfus @TheDMMcC @JoannaMasel @jgschraiber for feedback!
academic.oup.com/gbe/article…
Here comes (new version of) my preprint w/ @mwpen on how hidden aspects of the mutational input not captured by the M-matrix affects the course of evolution!
biorxiv.org/content/10.1101/…
It's official! My paper (with @mwpen & @ribonucleicacid) on the evolution of gene product diversity (RNA/protein expressed from this same gene having alternative isoforms) is now online at @MolSystBiol!
embopress.org/doi/full/10.10…
Full 🧵 introducing the study is here: bsky.app/profile/rexjiang.bs…
I’m very much done with this app but here’s something for which I’m willing to come back & tweet…
Our paper on the evolution of gene is just accepted at @MolSystBiol !🥳
Final version coming soon!
Our new preprint is out! Thread🧵
Genetic and selective constraints on the optimization of gene product diversity biorxiv.org/content/10.1101/…
Here comes (new version of) my preprint w/ @mwpen on how hidden aspects of the mutational input not captured by the M-matrix affects the course of evolution!
biorxiv.org/content/10.1101/…
Our new preprint is out! Thread🧵
Genetic and selective constraints on the optimization of gene product diversity biorxiv.org/content/10.1101/…
This work is done together with @mwpen, and @ribonucleicacid group. Our groups have even more amazing works coming out these days, and you're all welcome to check them out as well!
This finding shows different optimization strategies: at moderate Ne, a global solution is selected for, as local optimization is impossible in face of mutational pressure and drift; at large Ne, local optimization of cis- loci is possible, and constraint is lifted.
Got to visit the (in)famous Oceanwide Plaza in DTLA today—these unfinished buildings are owned by a Chinese company that failed to pay its debt, and later decorated by graffiti. #OceanwidePlaza #graffiti
Biked to @labreatarpits for the second time today. Visiting such awesome places reminds me that biology is still fascinating.
This paper on TFBS evolution is finally out near the end of 2023. Now all my thesis chapters are published. 2023 also happened to my "big year" in terms of publication (not in terms of mental health and some other things though)...
academic.oup.com/mbe/advance…









