Assistant Professor in Systems Biology of cancer at TU Eindhoven
Eindhoven, Nederland
Joined March 2012
- Tweets93
- Following96
- Followers205
- Likes43
Federica Eduati retweeted
🧵 New preprint: Logic models can simulate cancer signalling & screen drug targets in silico, but they need perturbation data & hand-curated networks patients lack.
We present FICUS for building dynamic logic models directly from patient omics.
📄 doi.org/10.64898/2026.06.19.…
Excited to share our latest work on SPoTLIghT, a computational tool for analyzing the spatial architecture of the tumor microenvironment (TME) from histopathology images. #CancerResearch #Oncology #PrecisionOncology
rdcu.be/dZujx
@TUeindhoven
🧵 1/8
SPoTLIghT is open-source and available on GitHub for other researchers to explore and expand. Check it out here: github.com/SysBioOncology/SP… #OpenScience 🧵 7/8
In summary, SPoTLIghT is a great tool for mapping the tumor microenvironment from H&E slides, paving the way for new spatial biomarkers with the potential to improve patient outcome predictions. Huge thanks to first authors @LapuenteSantana & Joan Kant for their work! 🧵 8/8
Federica Eduati retweeted
This week in #MathOnco 292:
> Project Optimus, radiotherapy, mutation accumulation, and deep learning / AI....
Art:
@Maisaavg & @FEduati 💯😎
Signup:
mathematical-oncology.org/ne…
1/5 Now published @Nature_NPJ our paper leveraging multicellular computational modeling to study the effect of androgen deprivation therapy (ADT) on the prostate tumor microenvironment (TME). Great work of @Maisaavg @anniek_zaalberg @JJPKneppers
with @zwartlab and BergmanLab
4/5 Additionally, ADT has immunomodulatory effects on the TME, impacting macrophage-mediated tumor cell killing.
Understanding these complex interactions within the TME through computational modeling could pave the way for novel therapeutic strategies targeting the TME to combat CRPC. Read the paper rdcu.be/dzc1d. @TUeindhoven @NKI_nl
Check out our latest work showing how heterogeneity in the TME is functionally associated with immune response. Great collaboration with @Francesca_Fin_ group, check her thread for more info
📢Thrilled to share our latest work on TME heterogeneity! A joint effort with @FEduati lab, led by @LapuenteSantana and @grsturm
shorturl.at/fLNS4
@uniinnsbruck @imed_tweets @TUeindhoven
Follow the thread for more🧵👇
1/5
Our paper on modelling the prostate cancer #tumordevelopment is now published in @CRC_AACR !!! @TUeindhoven @NKI_nl #CancerResearch #prostatecancer #systemsbiology
Just published—
Exploring the onset and progression of #prostatecancer through a multicellular agent-based model, by Passier et al.
bit.ly/3Df53pe
@TUeindhoven #openaccess
Federica Eduati retweeted
📢#PhD and #PostDoc positions in my group at @uniinnsbruck @DiSC_uibk to computationally reconstruct cancer interactomes from NGS multiomics
@FWF_at project in collaboration with @LabiLab5 @villunger @_JoelRiley
euraxess.ec.europa.eu/jobs/7…
euraxess.ec.europa.eu/jobs/7…
Please RT! 🙏
1/8: In our new work with @zwartlab and Bergman's lab @NKI_nl, Margot Passier led the development of an agent-based model of a prostatic acinus to study prostate cancer (PCa) development in silico. #prostatecancer #cancerresearch @TUeindhoven
8/8: Our study sheds light on the complex and multifactorial nature of PCa development, and highlights the importance of understanding the role of the tumor microenvironment in tumor initiation and progression.
Check out the bioRxiv preprint to learn more: biorxiv.org/content/10.1101/… #tumordevelopment #microenvironment #prostatecancer Thanks to all co-authors for their hard work and dedication.
