@FGH_Lab

DNA repair and Gene Expression in human disease. Andalusian research group. Find us at @IBiS_Sevilla

 Seville, Spain
grupo.us.es/gomezherreroslab/gomezherreroslab/Home.html
Joined May 2016
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  • Following673
  • Followers649
13Media
New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis_sevilla @InvestigaUS
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Very excited to announce the workshop "DNA–Protein Crosslinks: Mechanisms and Links to Rare Genetic Disorders", which will take place in Baeza (Spain) from 18–20 November 2026! unia.es/estudios-y-acceso/of…
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High demand! Please find the registration information at the previous link. Reduced registration fees are available for students and early-career postdoctoral researchers.
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Fernando Gomez-Herreros Lab retweeted
Joaquin Olmedo@olmedo_pelayoJJun 10
Thrilled to share our latest preprint biorxiv.org/content/10.64898…. In this study, we identified EXO1 as a clinically relevant, targetable candidate in Ewing sarcoma.

EXO1 Facilitates MiDAS and Prevents Genome Instability and Cell Death in Ewing Sarcoma

Ewing sarcoma (EwS) is an aggressive malignancy driven by EWSR1::ETS fusions, predominantly EWSR1::FLI1. Previous efforts using both direct and indirect approaches to target these chimeric oncoprot...

biorxiv.org
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Muy contentos y agradecidos de que el último trabajo del laboratorio haya sido seleccionado como artículo del mes por la @SEBBM_es !!🎉🎉 @ibis_sevilla @InvestigaUS
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@SEBBM_esFeb 6
#ArtículodelMes H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death Por @Diana_Rubio_ et al. f.mtr.cool/cybufwyhmj
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Fernando Gomez-Herreros Lab retweeted
Cristian Prieto-Garcia@CristianPG_mlgFeb 1
Our Science paper is out! 😀 Enjoy if you like SPRTN, DPCs, Innate immunity and Aging. science.org/doi/10.1126/scie…

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprote...

science.org
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Fernando Gomez-Herreros Lab retweeted
Diana Rubio@Diana_Rubio_1 Dec 2025
Excited to see our research published!! 🎉 Amazing project in @FGH_Lab at @ibis_sevilla, @unisevilla "H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death" nature.com/articles/s41419-0…
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These results support the potential role of TOP1-induced DSBs as a main contributor to certain hereditary neurological syndromes.
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A terrific work of @diana_rubio and @hidalgogarciaD with the support of all the lab. @josefra1975 @E__GranadoCalle
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Fernando Gomez-Herreros Lab retweeted
Diario de Sevilla@diariosevilla28 Aug 2025
Un estudio del Instituto de Biomedicina de Sevilla desvela un nuevo mecanismo de sensibilidad del sarcoma de Ewing a la quimioterapia #Sevilla #SevillaHoy ddsevilla.info/rbr9b1

Un estudio del Instituto de Biomedicina de Sevilla desvela un nuevo mecanismo de sensibilidad del...

La investigación, publicada en la revista Oncogene, muestra cómo una interacción molecular específica determina la eficacia del irinotecán en este tipo de tumor pediátrico

diariodesevilla.es
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Our latest study is now online at @oncogenejournal pubmed.ncbi.nlm.nih.gov/4072… A great collaboration between the @FGH_Lab and @LabHuvr labs, driven by the outstanding work of @olmedo_pelayoJ at @ibis_sevilla Check it out!

EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by...

Drug resistance is an ill-defined cause of dismal outcomes in cancer. Ewing sarcoma (EwS), a pediatric cancer characterized by high therapy failure rates, is driven by a single oncogenic event...

pubmed.ncbi.nlm.nih.gov
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👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents. 👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
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Grateful to all collaborators who made this work possible!
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Fernando Gomez-Herreros Lab retweeted
Joaquin Olmedo@olmedo_pelayoJ14 Apr 2025
Proud to announce that last Thursday I successfully defended my PhD thesis, “Understanding genome instability in Ewing sarcoma: from molecular mechanisms to novel therapeutic approaches”, at the @ibis_sevilla.
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Fernando Gomez-Herreros Lab retweeted
Hana Sedlackova@HanaSedlackova130 Mar 2025
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
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Fernando Gomez-Herreros Lab retweeted
RosadoLab@RosadoLab27 Mar 2025
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances science.org/doi/10.1126/scia…

HMCES corrupts replication fork stability during base excision repair in homologous recombination...

HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

science.org
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Fernando Gomez-Herreros Lab retweeted
Luis Lloredo Alix@llloredo14 Mar 2025
Se ha filtrado el borrador de ley de universidades que está preparando la CAM. Si se aprueba, será la muerte de la universidad pública madrileña. Es escandaloso. No exagero. Se vienen tiempos oscuros como no espabilemos. Explico algunos puntos críticos. Va hilo. 👇
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Diana Rubio@Diana_Rubio_4 Mar 2025
¡¡Premio Nacional de Juventud en Ciencia y Tecnología!! Gracias @InjuveSpain y @JuventudInfGob por dar visibilidad y reconocer la labor de los jóvenes investigadores en España. @ibis_sevilla @FISEVI_sevilla @FGH_Lab @InvestigaUS
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Fernando Gomez-Herreros Lab retweeted
Millán-Zambrano@GMillanZambrano17 Jan 2025
Have a look at our review in @MolecularCell . We explore how histone modifications serve as integrators of genome activity, mediating communication between distinct DNA procesess. authors.elsevier.com/a/1kS2f…
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