While AlphaFold3 improves upon the previous version, it still can't handle conformational changes during binding like our NeuralPlexer does. Paper: nature.com/articles/s42256-0… Summary: nature.com/articles/s41592-0… "NeuralPLexer can predict both apo and bound forms of proteins and can model the structural differences between the two states." "NeuralPLexer outperformed the protein structure prediction tool AlphaFold2 for accurately predicting the large structural plasticity associated with ligand binding in proteins known to undergo a large binding-induced conformational change."