🐦/🐺/🐻/🌉/💊/ 'i never tag no one in, I'd rather get you myself.' 🦉♏/
Berkeley, CA
Joined May 2013
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Updated preprint up - direct supplementation with the metabolic cofactor Coenzyme A reverses macrophage immunosuppression + promotes pro-inflammatory & anti-microbial macrophage phenotypes via positive influence on CoA-dependent glucose metabolism (1/x) biorxiv.org/content/10.1101/… – at Berkeley, CA
Greg Timblin retweeted
Pleasure to write this News & Views on this elegant work from the Belousov lab, which engineers a chemigenetic bypass of mitochondrial pyruvate uptake. A truly creative advance that expands the experimental toolkit for studying mitochondrial metabolism.
rdcu.be/2ggNASE7YxWa
Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells
nature.com/articles/s41589-0…
Greg Timblin retweeted
CD36 complexity: In humans, loss-of-function increases risk for cardiomyopathy. However, in the present murine ischemia-reperfusion injury model, CD36 suppression improves cardiac function highlighting potential contextual difference in chronic vs acute reactive myocardial fatty acid uptake nature.com/articles/s41467-0… @NatureComms
Greg Timblin retweeted
Today I'm posting a new video to my YouTube Channel. Persistent misnaming of 17-OHPC as "progesterone" in medical literature lead to pregnant women receiving the wrong drug through compounding pharmacies: youtu.be/I1C9aDfLH-U
Greg Timblin retweeted
You ever just sit in a dark room and feel like the darkness is the only thing that truly understands you. No fake smiles, no false hope. Just raw bitter silence…
Greg Timblin retweeted
This has been the case for years and AI + China is causing it to spike. There will be huge value destruction in modalities like ADCs while VCs fund what's known instead of what's differentiated as if they think their role is to be in the same point in the risk curve as pharma.
If you're in line with a shiny new MoA that is a clear + significant advance over Me Toos but getting overlooked in current climate, just figure out a way to stay in line...it will pay off – at Berkeley, CA
The degree of target clustering in pharma right now is absolute madness. How is this not objectively idiotic?
The pendulum will swing back to unique/novel MoAs eventually…it just has to.
Right now you can get VALIDATED novel/unique MoAs for less than some of these me-80 drugs in some cases. The system seems broken.
Greg Timblin retweeted
Insane; not enough patients for all these TSLP drugs. 😆 I saw there are 79 TSLP candidates but I guess it depends how broad you go and structure.
There are no competitors with my R&D programs, to my knowledge.
Windward Bio, a Swiss startup with Phase 2 drug candidates from a few China-based biotechs, files for a Nasdaq IPO
TSLP and TSLPxIL13 candidates in clinical trials across asthma, COPD + eczema
Novo Holdings, OrbiMed & CEO are largest shareholders
endpoints.news/windward-bio-…
Greg Timblin retweeted
The degree of target clustering in pharma right now is absolute madness. How is this not objectively idiotic?
The pendulum will swing back to unique/novel MoAs eventually…it just has to.
Right now you can get VALIDATED novel/unique MoAs for less than some of these me-80 drugs in some cases. The system seems broken.
Greg Timblin retweeted
Interventional murine and observational human studies implicate the restoration of intracellular taurine and mitigated NLRP3 inflammasome activation. Taurine is a dietary non-essential AA, synthesized from cysteine during ↓ food intake or when diets are largely plant based sciencedirect.com/science/ar… @CellCellPress
Sigh – at Berkeley, CA
🙌 Kenenisa Bekele 🙌 tiene 44 tacos y un reto pendiente que parece increíble: BAJAR DE LA HORA en una media maratón.
Este domingo, en el @MedioMaratonVLC , una de las mayores LEYENDAS de la historia del #atletismo podría intentar saldar una cuenta pendiente de su impresionante carrera deportiva.
Sus marcas personales son de otro planeta:
🔥 3.000 m: 7:25.79
🔥 5.000 m: 12:37.35
🔥 10.000 m: 26:17.53
🔥 Media maratón: 1:00:09
🔥 Maratón: 2:01:41
Su récord en media maratón data de 2013.
El objetivo no es sencillo. El paso del tiempo no perdona ni siquiera a los más grandes, y hay quien duda de que pueda acercarse a esa marca.
PERO BEKELE ES BEKELE
Descartarlo siempre tiene sus riesgos
Greg Timblin retweeted
This is how Dr. Seuss probably talk smack. “It’s no sausage, but it might be a little green eggs and ham, you know what I mean? Jaylen I am”
Greg Timblin retweeted
The body of evidence is abundant that macrophages are key in chronic pain - they are to pain what mast cells are to itch
Tissue-resident macrophages sense colonic stiffening via Piezo1, releasing NGF to sensitize TRPV1+ nociceptors for visceral pain @SciImmunology
science.org/doi/10.1126/scii… 🇨🇳
