Associate Prof @MITChemE ; mom^4 + wife; enjoys building cell-fate circuits, exploring dna topology, reprogramming the living world, and soccer; soli gloria deo
Joined June 2019
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Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
Katie Galloway retweeted
Few poems describe a gentleman's character better than Kipling's "If—," and few men read it better than Sir Michael Caine.
Have a great Friday.
Katie Galloway retweeted
Massively parallel assays using oligopools, barcoding, & deep sequencing follows the same story.
Replaces 100s of microtiter plates (one assay per well) with 10000s of experiments run in one pooled assay.
Work your 🧠, not just more 🤖.
Last year, we spent a lot of time thinking about to engineer some of the most complex cellular systems: lung, heart, blood, and sleep systems! In case you missed it, you should check out some of that vision from @SynBioGaoLab @sahakris @LaurieBoyer1221 @BashorLab @yogeshgoyallab @genegirl007 @isaacbhilton @Pulin_Li @jasonhyang @echaikof and many more! Link below:
What if a single RNA transfection could program human stem cell fate or enable functional biosensing for more than a month?
Our new @CellRepMethods paper explores how self-amplifying RNA makes this possible, without genomic integration. 1/n :🧵
Integrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems
"By integrating genome engineering, dynamic gene circuits, and high-dimensional biosensors, these advances support scalable, quantitative models of multicellular biology, expanding the need for systems-level models and integration. We highlight emerging systems such as tunable transcriptional regulators, synthetic organizers, and feedback circuits that bridge molecular control with functional outcomes." tinyurl.com/LungHeartBloodSl…
What if a single RNA transfection could program human stem cell fate or enable functional biosensing for more than a month?
Our new @CellRepMethods paper explores how self-amplifying RNA makes this possible, without genomic integration. 1/n :🧵
Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs dlvr.it/TVWHCk
Want to know more? You can read the paper here: dlvr.it/TVWHCk
