@GaoLab_

Exploring the genetic diversity of Earth's microbiome. Stanford Biochemistry | Run by lab members.

 Stanford, CA
gaolab.bio
Joined July 2026
  • Tweets11
  • Following57
  • Followers11
3Media
This week, we tried to guess the number of MiSeq flow cells we’ve collected since starting the lab! Displayed: our expert lab guessers!! What would you have guessed?👀🥳
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Many important bacterial non-coding RNAs and structural elements remain undiscovered. To help, @_David_Li, @garykbrixi, @mfgrp, @BrianHie & team introduce Minerva, which uses a genome language model to predict RNA base pairing, repeats, & other interactions from sequence alone.
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Hannah and Simone co-taught a crash course on cryoEM to the 1st year Stanford medical students !
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Gao Lab retweeted
David Li@_David_LiSep 22
Excited to share Minerva, our approach using genome language models for biological discovery! Using Minerva, we find that UG27 reverse transcriptase systems encode variable arrays of diverse ncRNAs with a shared structure, each templating a short DNA hairpin. With @garykbrixi.
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Congratulations to Pujuan on receiving the Katharine McCormick Advanced Postdoctoral Scholar Fellowship! This fellowship supports exceptional postdocs pursuing faculty careers who have demonstrated a track record of uplifting women in science. Excited to see what’s next for you!
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In contrast, Upx, despite sharing no sequence or structural homology with Avs2, is predicted to recognize phage terminase by binding unfolded terminase ATPase domains, via β-augmentation. (3/4)
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Two different structural solutions to the same sensing problem. Congrats to all who contributed! 🥳🧬(4/4)
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They solved a 2.3 Å cryo-EM structure of Avs2 bound to phage terminase, with an unexpected ATP molecule bridging the two proteins at their interface. (2/4)
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Congratulations to Simone (@simone_alma), Collin, and Max (@maxewilkinson) on their paper - out today- on terminase sensing by Avs2 and Upx! (1/4) nature.com/articles/s41467-0…

Phage terminase recognition by the bacterial immune sensors Avs2 and Upx

Nature Communications - Direct recognition of viral proteins is key to bacterial immunity. Here, Evans et al. uncover the mechanisms used by two distinct defense proteins to detect the phage DNA...

nature.com
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We’re so excited to share our new paper, where we tackle the wealth of structural and functional diversity of anti-phage sensors across bacteria (1/6)
nature
@NatureJul 29
Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/4w2kf25

Diverse bacterial pattern recognition receptors sense the core phage proteome

Nature - Systematic analysis of prokaryotic STAND NTPases — relatives of animal and plant immune receptors — uncovers diverse antiviral sensors that detect most of the core structural...

nature.com
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Immune recognition is far more universal than we thought! Our new paper uncovers ≥ 90 families of bacterial immune receptors that recognize conserved phage proteins. We also reveal how Avs7 recruits EF-Tu to assemble an immune complex. Congrats to Hyunbin, Sofia, & others !!
nature
@NatureJul 29
Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/4w2kf25

Diverse bacterial pattern recognition receptors sense the core phage proteome

Nature - Systematic analysis of prokaryotic STAND NTPases — relatives of animal and plant immune receptors — uncovers diverse antiviral sensors that detect most of the core structural...

nature.com
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