@GitlinLab_MSK

Assistant Member/Professor, Lab Head @MSKCancerCenter ex-@Genentech @StanfordPath @TriIMDPhD. #PhysicianScientist #Immunologist. Views my own.

 New York, USA
mskcc.org/research/ski/labs/alexander-gitlin
Joined March 2019
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🚨Thrilled to share our latest work, published online today @Nature in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @MSKCancerCenter led by superstars @VarunNarendraMD + @das_tandrila 🧵1/ nature.com/articles/s41586-0…

Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome

Nature - UBA1-mutant macrophages exposed to inflammatory stimuli undergo aberrant apoptotic and necroptotic cell death mediated by CASP8 and RIPK3–MLKL, offering insights into the mechanisms...

nature.com
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Beautiful work. Congrats Vishva, Cris and team!!
Vishva Dixit
@dixitvishvaSep 22
SURPRISE! Key interferon-stimulated genes (ISGs) can be induced without interferon! Sounds like an oxymoron, but it is true! Read the paper to find out more. Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation: Cell cell.com/cell/fulltext/S0092…

Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory...

Toll-like receptor signaling activates proinflammatory interferon-stimulated genes (ISGs) even in the absence of interferon by triggering a shift from IRF2 to IRF1 occupancy at ISG promoters and...

cell.com
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Caleb Lareau
@CalebLareauSep 9
Three years ago, my lab at @MSKCancerCenter set out to see if we could harness AI for new therapeutic proteins. Today in @natBME, our first step in developing these AI-designed molecules as anti-tumor therapies is online. Read more here: 1/n mskcc.org/news/using-ai-to-d…
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Sholto David@addictedtoigno1Aug 26
A few months ago I was browsing google images looking at p53 western blots in the SK-OV-3 cell line for an unrelated project. I noticed an unusual western blot hosted on Thermo Fisher's website which I posted on social media. Usually I just post weird blots to PubPeer. 👇
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Karuna Ganesh@KarunaMDPhDAug 5
ZFP36L2 binds AU-rich 3'UTRs of stress transcripts, sequesters them in dynamic condensates, and terminates the stress response. Only then can differentiated cells rewind into an LGR5+ ISC state.
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Quinn@QuinlanSieversJul 22
⭐️Proud to share my postdoctoral work from the @AbdelWahablab that we conducted in collab with @Nurix_Tx and @TaylorJ_MD!⭐️ In this paper we characterize one of the first clinical resistance mutations to a PROTAC, aka a heterobifunctional degrader aacrjournals.org/cancerdisco…

Molecular and Structural Basis of Pan-Resistance to BTK Degraders and Inhibitors

AbstractEarly-phase clinical trials of Bruton’s tyrosine kinase (BTK) degraders have demonstrated efficacy in patients with BTK inhibitor–resistant chronic lymphocytic leukemia (CLL). How clinical...

aacrjournals.org
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Caleb Lareau
@CalebLareauJun 18
Our lab is looking for a (junior) research technician to help accelerate several exciting projects in the lab, including our preclinical assessment of AI-designed biologics, single-cell technology development, and structure/function of viral proteins. jobrxiv.org/job/memorial-slo…

Research Technician at Memorial Sloan Kettering-New York, NY

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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🎉Congratulations to MSK pathologist Dr. Alexander Gitlin for being named a 2026 Pew-Stewart scholar! Dr. Gitlin will uncover how cell signaling controls the nature and magnitude of inflammation in normal physiology and in disease, focusing on the intersection of inflammatory signaling and cell death pathways.
The Pew Trusts@pewtrustsJun 16
Replying to @pewtrusts
And finally, meet the 2026 Pew-Stewart scholars. These five scientists are tackling some of cancer research’s biggest questions, from pioneering new strategies to engineering lifesaving treatments. pew.org/en/about/news-room/p…
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Thanks @MSKCancerCenter and @pewtrusts! Grateful for this support and recognition!
Memorial Sloan Kettering Cancer Center
@MSKCancerCenterJun 16
🎉Congratulations to MSK pathologist Dr. Alexander Gitlin for being named a 2026 Pew-Stewart scholar! Dr. Gitlin will uncover how cell signaling controls the nature and magnitude of inflammation in normal physiology and in disease, focusing on the intersection of inflammatory signaling and cell death pathways.
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The Pew Trusts@pewtrustsJun 16
🎉 Today we welcome 36 researchers to our network of innovative, early-career scientists. Learn more about the new class of scholars and fellows below👇 pew.org/en/research-and-anal…

These 36 Scientists Are Leading the Way to Biomedical Discoveries

On June 16, Pew announced the 2026 class of Pew Scholars Program in the Biomedical Sciences, Pew Latin American Fellows Program in the Biomedical Sciences, and Pew-Stewart Scholars Program for Cancer...

pew.org
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Vishva Dixit
@dixitvishvaJun 13
A terrific perspective from Ivan Dikic linkedin.com/feed/update/urn…)

Genentech R&D layoffs hit top exec who’s been with the biotech nearly 30 years | Ivan Đikić | 57...

The recent departures of several highly respected Genentech scientific leaders, including Ira Mellman earlier and now vishva dixit, Kim Newton, Man-Wah Tan, Todd McDevitt, and others, have sent...

linkedin.com
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Mara Sherman Lab
@MaraShermanLabApr 20
Replying to @shouval_lab
@shouval_lab @SnehaPramod @hagargir and I reflect on the work of the ✨ TME community in a new review re fibroblasts in cancer @NatureCancer. 2025 was my yr to 🩵 the distraction of writing (IYKYK), so thx to all whose discoveries made this so gratifying. nature.com/articles/s43018-0…

Heterogeneity and plasticity of cancer-associated fibroblasts

Nature Cancer - Sherman and colleagues provide an overview of the current understanding of the heterogeneity and plasticity of cancer-associated fibroblasts.

nature.com
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William Gibson
@wgibsonApr 13
RevMed just doubled overall survival in pancreatic cancer by using CypA-targeting molecular glues to potently drug oncogenic KRAS-ON, long deemed untouchable. One funny thing is that probably the most fundamental insight for daraxonrasib sits in a PNAS paper that's been cited merely 84 times. This showed that molecular glues can coax an endogenous protein to wrap itself around utterly featureless surface. The other is a 2017 Cell Reports paper (just 68 citations) on how Sanglifehrin A can be used to repurpose CypA's surface. A lot of the game-changing stuff seems niche and unglamorous at first. Greg Verdine is having a chembio Annus Mirabilis for his 2025-2026 streak: FOG-001, Daraxonrasib. He provided much of the foundational conceptual work behind taking out both Beta-catenin and KRAS*. *of course many others contributed immensely, but let's give some credit where credit is due!
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Andrew Ji@andrewljiMar 23
Thrilled to share our new @NatureGenet paper! We mapped human skin at single-cell spatial resolution and found that anatomy is encoded in cell states and neighborhoods, led by PhD student @paularstrpo. Link: nature.com/articles/s41588-0… 1/9

Single-cell spatial transcriptomic analysis of human skin anatomy

Nature Genetics - This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets...

nature.com
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Roger Greenberg@RogerRogergrMar 21
Great work in Mol Cell from John Maciejowski's group delineating BAF dependent regulation of TREX1 and cGAS in micronuclei. Very important implications for immune responses to chromosome instability. cell.com/molecular-cell/abst…
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Abdel-Wahab Lab@AbdelWahablabMar 11
Excited to announce a paper out today in @natgenet.nature.com identifying an approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with @KellyLBolton @WashU and led by @IrenaeusChan & @PuZhang09980432 nature.com/articles/s41588-0…

CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis

Nature Genetics - Analysis of clinical trial data suggests that CDK4/6 inhibitors prevent the expansion of TP53-mutant clones in the blood, potentially mitigating the risk of secondary myeloid...

nature.com
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Walczak Lab@Walczak_LabMar 6
Excited to share our new work uncovering a previously unknown mechanism identifying ANKIB1 as the E3 ligase that writes a critical new letter of the ubiquitin code central for immune signalling: K11-linked ubiquitin nature.com/articles/s41556-0…

Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like...

Nature Cell Biology - Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with...

nature.com
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Congrats @Walczak_Lab on this exciting new discovery!!🔥 👏 #ubiquitin
Walczak Lab@Walczak_LabMar 6
Excited to share our new work uncovering a previously unknown mechanism identifying ANKIB1 as the E3 ligase that writes a critical new letter of the ubiquitin code central for immune signalling: K11-linked ubiquitin nature.com/articles/s41556-0…

Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like...

Nature Cell Biology - Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with...

nature.com
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🎉 Congratulations to MSK physician-scientist @KarunaMDPhD and colleagues, who are part of an international team awarded a @CancerGrand grant — a prestigious global award providing up to $25M over five years to tackle some of the toughest challenges in #cancerresearch. The team will explore new ways to “rewire” cancer cells and prevent treatment resistance in #colorectalcancer, one of the leading causes of cancer-related deaths. Learn more: bit.ly/4d1GX4p
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Lydia Finley@lydfinleyFeb 27
Cell-state dependent reliance on portions of metabolic networks is the topic of the other paper from @jules_stef published this week (!) in @MolecularCell cell.com/molecular-cell/full…

Aspartate availability drives differential engagement of the malate-aspartate shuttle

Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate...

cell.com
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