Group leader at @UCPH_health, working on RNA-binding proteins and co-transcriptional regulation. Previously at @UPCH_BRIC, @BIMSB_MDC and @TheCrick
Joined November 2020
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❗️5 days left to apply for a PhD position in our group👇
🧬 Passionate about transcription?
🚀 We’re recruiting a PhD student in Transcriptional Regulation @UCPH_health in Copenhagen
Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab 👩🔬👨🔬 gregersenlab.com
Apply by Apr 10, 2026
tinyurl.com/PhD-CGEN
🧬 Passionate about transcription?
🚀 We’re recruiting a PhD student in Transcriptional Regulation @UCPH_health in Copenhagen
Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab 👩🔬👨🔬 gregersenlab.com
Apply by Apr 10, 2026
tinyurl.com/PhD-CGEN
What is the function of the RNAPII-interacting SCAF proteins?
In our latest work, led by Smaragda Kompocholi, we show that SCAF1 shapes mRNA isoform expression during neuronal differentiation 🧬🧠
Loss of SCAF1 → shorter mRNA transcripts
biorxiv.org/content/10.64898…
Thank you to collaborators Gertrud Hjortø, Tom Miller, @JZylicz and support from colleagues at @UCPH_health
What happens to transcription upon oxidative DNA damage? 🧬💥
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀 How? Find out in our new preprint👇
biorxiv.org/cgi/content/shor…
Thank you to everyone involved and support from colleagues at Center for Gene Expression (CGEN), @UCPH_health!
Key takeaways:
🔍Oxidative damage causes shutdown of transcription, without RNAPII degradation
🔍Stalled RNAPII resumes transcription from within the gene body
🔍PARylation controls early elongation restart
🔍BER and SSBR repair enable RNAPII recovery in the gene body
This beautiful work, led by Quentin Thomas, revealed a surprising spatial organization of the transcriptional response:
• Promoter regions: PARylation governs early RNAPII release
• Gene body: DNA damage and repair drive RNAPII stalling
Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure RNAPII elongation rates across 3,000+ genes 🧬genome.cshlp.org/content/ear…
Fantastic work led by @liu_haiyue
More details below! 👇
#Genomics #Transcription #RNAPII #ElongationRates
What did we find? ✅ Elongation rates vary between genes ✅…and within genes ✅ Histone marks & elongation factors correlate with rate subclasses
The computational pipeline independently applies to existing DRB/TTchem-seq datasets - so you can improve the number of genes with single gene elongation rates from existing data, simply by using the new computational pipeline
Existing methods either rely on indirect estimates or are limited to a handful of long genes. So we built DRB/TTchem-seq2: Short timepoint sampling, new computational framework 📈 leading to a ~7 fold increased individual gene elongation rates measurements!
❗️One more week to apply for a PhD position in our group! Come join our team of transcription enthusiasts in Copenhagen👩🔬👨🔬
We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs
@uni_copenhagen. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com) Great city and amazing research environment. Deadline March 6 jobportal.ku.dk/phd/?show=16…
Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @uni_copenhagen. Want to join our team to work on transcriptional regulation? More information at: gregersenlab.com/ Deadline March 18. Apply here: jobportal.ku.dk/phd/?show=16…
We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs
@uni_copenhagen. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com) Great city and amazing research environment. Deadline March 6 jobportal.ku.dk/phd/?show=16…
Lea Haarup Gregersen retweeted
Looking for a #postdoc or #PhD in eukaryotic #DNA replication and #CryoEM? We are recruiting! The positions are fully-funded by the @novonordiskfond and come with access to cutting-edge facilities and fantastic colleagues in #Copenhagen. See links below for more information.
Happy to be back among old colleagues and friends in Berlin mixed in with amazing science 🧫
Proud to showcase a selection of our alumni during session 2 of the Berlin Summer Meeting 2023: Pinar Önal, @baris_tursun @TursunLab, Elena Torlai Triglia, Lea Haarup Gregersen @GregersenLab & @M_Munschauer
#mdcBIMSB2023
@MDC_Berlin
Great opportunity for a postdoc in Copenhagen 👇👇
We are recruiting a postdoc for a fully funded position in our group in beautiful Copenhagen! We encourage anyone interested in #DNAmethylation and/or #Bioinformatics to apply.
Deadline: 17 September
Apply here: employment.ku.dk/faculty/?sh…
Please retweet!
Great opportunity for a PhD position 👇👇
📢 PhD scholarship in Copenhagen 🇩🇰
Do you want to...
🧬 study how ubiquitination regulates cellular metabolism in disease states?
👩🔬 join an international and ambitious team?
✅Then apply here before 11 Sep to join my team: efzu.fa.em2.oraclecloud.com/…
