@GroupFrancis

Chem Bio lab at @UCB_Chemistry developing bioconjugation methods and protein-based materials for drug delivery and more. #1 Tyrosinase superfan. (Student-run)

mbfberkeley.com/
Joined August 2018
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  • Following351
  • Followers1K
15Media
The Lab // The Laboratory
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Francis Group 🧪 retweeted
Alanna Schepartz@AlannaSchepartz31 Jul 2024
New preprint: "Ribosomal Synthesis of Ketone-containing Peptide Backbone via O to C Acyl Shift" chemrxiv.org/engage/chemrxiv… @cgem_cci @CarlySchissel @NSF @GroupFrancis @UCB_Chemistry @schepartzlab

Ribosomal Synthesis of Ketone-containing Peptide Backbone via O to C Acyl Shift | ChemRxiv

Despite tremendous efforts to engineer translational machinery, replacing the encoded peptide backbone with new-to-Nature structures remains a significant and largely unmet challenge. C, H, O, and N...

chemrxiv.org
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Francis Group 🧪 retweeted
Paige Pistono@PaigePistono24 Jul 2024
Happy to share that my final paper from grad school is out in @BiochemistryACS! We investigate how mutations at VLP assembly interfaces affect particle size, stability, and biological function. pubs.acs.org/doi/10.1021/acs…

Exploring the Effects of Intersubunit Interface Mutations on Virus-Like Particle Structure and...

Abstract. Virus-like particles (VLPs) from bacteriophage MS2 provide a platform to study protein self-assembly and create engineered systems for drug deliv

pubs.acs.org
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Francis Group 🧪 retweeted
MChangGroup@MChangGroup8 Jul 2024
Check out our review on the current state of biocatalysis. Congrats to the authors. nature.com/articles/s41586-0…

Expanding chemistry through in vitro and in vivo biocatalysis

Nature - This Review considers developments in enzymes, biosynthetic pathways and cellular engineering that enable their use in catalysis for new chemistry and beyond.

nature.com
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Our colleagues in the degrader field never run out of puns, do they? #ACSFall2023
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Come check out our work in the Francis Lab at #ACSFall2023! 🌁🏙🧪🧫
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✨ New C-GEM paper in @ACSCentSci! Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome Congrats to @chon_majumdar, twitterless Josh, @GroupFrancis, @schepartzlab, and @cate_lab on a beautiful collaboration pubs.acs.org/doi/10.1021/acs…

Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome

Abstract. The Escherichia coli (E. coli) ribosome can incorporate a variety of non-l-α-amino acid monomers into polypeptide chains in vitro but with poor e

pubs.acs.org
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Chem Bio in the Bay Area (CBBA) day this weekend featuring a talk on MS2 fitness landscaping from @PaigePistono and the lab meeting Carolyn Bertozzi 😎
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Francis Group 🧪 retweeted
Abby Knight@abigailsknight16 Mar 2023
Thrilled to see this paper online! The hystersis enthusiasm was 💯 initiated by Supraja, and we really enjoyed working with my former @GroupFrancis colleague, @obermeyergroup.
Knight Group UNC@KnightGroupUNC14 Mar 2023
We are excited to share our new paper out in @J_A_C_S! We describe tunable nonequilibrium hysteresis properties in model methacrylate polymers that show changes in solubility with temperature. 1/4
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Another Graduate Research Seminar in the books - Congrats to Hannah Martin @hannnah_99 on a great talk! Hannah is a 2nd-year in the group studying vaccine design for malignant gliomas.
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Hot off the presses, some antibody modification chemistry with our colleagues at Merck and the @Toste_Group! pubs.acs.org/doi/10.1021/acs…

Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions

Abstract. Cysteines are routinely used as site-specific handles to synthesize antibody–drug conjugates for targeted immunotherapy applications. Michael add

pubs.acs.org
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Congrats to @katejdolph on an excellent Graduate Research Seminar! Kate is a 2nd-year PhD student with the group studying the sequence space of IDP-based surfactants for drug delivery.
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Congrats to Paige and the team---Excited to share our latest application of fitness landscaping!
Paige Pistono@PaigePistono15 Nov 2022
I'm excited to share that my 1st first-author paper is out now in ACS Chemical Biology! We've engineered MS2 VLPs with localized positive surface charge that show increased uptake into mammalian cells and can be used to deliver small molecule therapeutics. pubs.acs.org/doi/10.1021/acs…

Fitness Landscape-Guided Engineering of Locally Supercharged Virus-like Particles with Enhanced...

Abstract. Protein-based nanoparticles are useful models for the study of self-assembly and attractive candidates for drug delivery. Virus-like particles (V

pubs.acs.org
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Tyrosine or bust!!!
This Post is from an account that no longer exists. Learn more
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Join us Nov 17 | 1:00pm PST for a talk that will light up your Thanksgiving dinner with chemistry. Our "foodolgoist" Prof. Matt Francis @GroupFrancis will discuss some of the chemistry behind your Thanksgiving favorites. Need to register to attend. bit.ly/3CzgEz0
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“As soon as I heard her name in Swedish, I sent it, and I got an emoji back immediately — the shocked face emoji 😱. She’s a total rock star, and this is well deserved.”
UC Berkeley
@UCBerkeley5 Oct 2022
Chemistry Nobelist Carolyn Bertozzi’s years at UC Berkeley news.berkeley.edu/2022/10/05…

Chemistry Nobelist Carolyn Bertozzi’s years at UC Berkeley - Berkeley News

Bertozzi, who shared the 2022 Nobel Prize in Chemistry, received her Ph.D. from Berkeley. She later became a professor in the College of Chemistry, where she conducting her seminal work.

news.berkeley.edu
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Big congrats to Francis lab member Derek Manuel García Almedina, who took home the poster award at last week's QBI conference for his work on tyrosinase-enabled construction of bispecific antibodies!
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The group on the whole made quite the showing...Matt wasn't able to stick around for the photo booth :(
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Francis Group 🧪 retweeted
Science at Cal@ScienceAtCal15 Sep 2022
Grounds for Science is BACK at Cafenated Coffee Co. in Berkeley on Oct. 4 at 5:30 PM! 😻☕️ Ft. TWO Ph.D. Candidates from @UCB_Chemistry—@AMMGest of @MillerChemBio & @chembiobischoff of @GroupFrancis! REG: Grounds-Oct-2022.eventbrite.…
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Join us on Monday for our first Career Chat with @CharkoudianLou and @LeahWitus! We're excited to learn what it's like to be a professor at a primarily undergraduate institution (PUI) and how to prepare for this career path. RSVP👇 eventbrite.com/e/career-chat… #ChemTwitter #PhDChat
Banner image advertising a Career Chat that is open to all. The event is titled "Teaching and Research at a Primarily Undergraduate Institution" and is Monday, August 8th from 10-11am Pacific time or 1-2pm Eastern time. The event will be on Zoom and interested participants should RSVP using the link in the tweet. The banner features images of the two panelists - Professor Lou Charkoudian, PhD at Haverford College, and Professor Leah Witus, PhD at Macalester College. The event is organized by C-GEM, the NSF Center for Genetically Encoded Materials.

ALT Banner image advertising a Career Chat that is open to all. The event is titled "Teaching and Research at a Primarily Undergraduate Institution" and is Monday, August 8th from 10-11am Pacific time or 1-2pm Eastern time. The event will be on Zoom and interested participants should RSVP using the link in the tweet. The banner features images of the two panelists - Professor Lou Charkoudian, PhD at Haverford College, and Professor Leah Witus, PhD at Macalester College. The event is organized by C-GEM, the NSF Center for Genetically Encoded Materials.

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