The Guccione lab is interested in identifying new therapeutic targets in oncology.
Joined January 2020
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GuccioneLab retweeted
Excellent article that highlights the contribution of NIH grant funding to fueling economic activity. An important read especially for non- scientist to understand how disruptive NIH cuts are both to medicine and to the economy.
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report forbes.com/sites/michaeltnie…
Awesome opportunity
We are looking for a talented postdoctoral bioinformatician @TheDawsonLab to work with us on single cell multiomics incorporating lineage tracing and spatial technologies- we specifically want someone curious, fearless with a licence to innovate!! nature.com/naturecareers/job…
GuccioneLab retweeted
Strong article from Tom Maniatis, head of the NY Genome Center, on the history of the NIH and its role in maintaining U.S. scientific leadership. Safeguarding the future of biomedical science in the United States: Cell cell.com/cell/fulltext/S0092…
Here we characterize PRDM10 as an essential maternal transcription factor and dissect its role in regulating oocyte maturarion and oocyte-to-embryo transition!
On to the next!
Congrats to @meschmi the true mastermind behind this work!
nature.com/articles/s41467-0…
GuccioneLab retweeted
New in @Nature: Human-correlated genetic models identify precision therapy for liver cancer
rdcu.be/ebdH2
Josep Llovet and team @IcahnMountSinai validated the molecular profiles of preclinical models against human HCC data. #livercancer #HCC
GuccioneLab retweeted
Myeloid Cell Checkpoints: Ido Amit, Florent Ginhoux, and Miriam Merad addressed this topic in a symposium at the inaugural AACR IO Conference on Discovery and Innovation in Cancer Immunology.
#AACRIO25 @IdoAmitLab @FGinhoux @MiriamMerad
Now more than ever the message is: this research can soon have an impact on people’s lives. Do not defund science!Proud of this collab with @kimioishi and the whole #RNA modulation for therapeutics Lab (kudos to JinRong in particular!) journal-of-hepatology.eu/art…
GuccioneLab retweeted
"More than 99% of new drug approvals (2010-2019) were funded by NIH. Why dismantle the engine that made the U.S. a world leader in innovation and drug development ? #DoNotDefundScience jamanetwork.com/journals/jam…
GuccioneLab retweeted
Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution. science.org/doi/10.1126/scie…
GuccioneLab retweeted
The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. We urge Congress to restore stability to NIH: brnw.ch/21wQMO3
csr.nih.gov/RevPanelsAndDate…
link to check whether any study section is still happening. If NIH cannot post the study section on the national register then it cannot formally happen. The ripple effects can be devastating if no new funding is awarded.
Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder @Sleemmzz A huge thanks to all our collaborators @ggargiul_2020 @nickbar36316207 @owen_sansom @NIHFunding nature.com/articles/s41588-0…
It's out! If you look for a reliable reporter system for your Nucleic Acid Therapeutics needs, we got you covered!
The NATURA system is available to the community on Addgene. Congrats to Tommaso Tabaglio for leading this incredible effort! sciencedirect.com/science/ar…
GuccioneLab retweeted
Fantastic #PhD opportunity in #DataScience at @Sissaschool in #Triest, #Italy. Applications from #Bioinformatics to #cosmology and #Neuroscience. Deadline Feb14! datascience.sissa.it/how-to-…
GuccioneLab retweeted
End-of-the-year preprint 🧵! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?
GuccioneLab retweeted
The science of pasta cacio e pepe 🇮🇹👨🍳 "Finally, we present a scientifically optimized recipe based on our findings, enabling a consistently flawless execution of this classic dish."
Applied science at its best, with real-world impact
arxiv.org/abs/2501.00536
GuccioneLab retweeted
Very excited to share our latest work on the uncoupling of epithelial regeneration and tumorigenesis in the gut! nature.com/articles/s41586-0…
Amazing place to be!!
🚀 Exciting Opportunity! We're on the lookout for passionate young cancer biologists ready to take the lead in their own research group! Join us in a highly supportive environment and enjoy a competitive starting package. Let's make a difference together! 🌟 #CancerResearch