Multidisciplinary team of molecular architects using #medicinalchemistry & #molecularrecognition to design better medicines. 🧵 gunninggroup 🐘 gunninglabuoft
Mississauga, Ontario
Joined December 2019
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Thrilled to share our #OpenAccess online resource "An Introduction to Medicinal Chemistry & Molecular Recognition" on @OpenLibraryON! We designed this resource to provide budding medicinal chemists with the knowledge & tools to navigate small molecule drug discovery! #OER
Gunning Group retweeted
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—outgrowth of decades of NIH funded research
nejm.org/doi/full/10.1056/NE…
nejm.org/doi/full/10.1056/NE… @NEJM
nytimes.com/2025/05/15/healt…
Gunning Group retweeted
NEW SITE LAUNCH! braincancercanada.ca
NEW! Researchers & Scientists: braincancercanada.ca/researc…
NEW! Patient & Caregiver Resources
braincancercanada.ca/patient…
NEW! Projects Funded
braincancercanada.ca/project…
NEW! Community
braincancercanada.ca/communi…
#braincancer
Gunning Group retweeted
In case you missed it:
'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development'
Fom Patrick Gunning and colleagues at @GunningLabUofT
buff.ly/FMUUweh
Gunning Group retweeted
Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability | Journal of Medicinal Chemistry pubs.acs.org/doi/abs/10.1021…
Excited to share our latest work on an exquisitely selective #PROTAC of #HDAC6 in #JMedChem @ACSBioMed @ACSPublications!! TO-1187 is a highly potent HDAC6 degrader with complete proteome selectivity, sparing all #CRBN neosubstrates and other #HDAC isoforms.
Congratulations to first authors Harsimran Garcha and @OlutobiOlaoye, co-authors @Taleb_Sedighi, Daniel Pölöske, Pearla Hariri, Wenlong Yu, @d_abdallah98, & our longtime friend and collaborator @richard_moriggl for this work! @Patrick_Gunning @e_dearaujo pubs.acs.org/doi/10.1021/acs…
Do you find multi-step #PROTAC synthesis to be laborious and time-consuming? We present our latest work in @ChemCommun on a microwave-assisted #SNAr methodology for rapid preparation of #pomalidomide-based #PROTACs!
#targetedproteindegradation #molecularglues
Take a look at 'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development'
New from Patrick Gunning and colleagues at @GunningLabUofT
buff.ly/FMUUweh
We optimized conventional conditions for fluorothalidomide SNAr (overnight, oil bath heating) to achieve improved yields on gram-scale in only 15 minutes under microwave irradiation, exemplifying the method by preparing the clinically explored PROTAC #bavdegalutamide (ARV-110)!
Congratulations to first authors @d_abdallah98 and @brohannes10, co-authors Lina Hasan, Naman Patel, Timothy Wright, @bilalsaqib_, and many thanks to our collaborator @theKeillors for this excellent work! @Patrick_Gunning @e_dearaujo
Gunning Group retweeted
Check out our paper on proton pump inhibitor activation in cells in @NatureChemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@RedoxDKFZ). More collabs between our groups @DKFZ to come! rdcu.be/eaDjn
Gunning Group retweeted
🗞️
"Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F–13C two-dimensional NMR" ⤵️
@UofT &+
With #NSERCsupport.
Excited to share our new paper in @rsc_chembio on improving resolution in fluorotryptophan protein NMR by expanding into the 13C dimension! We prepared & used a 13C-labelled F-Trp precursor to achieve unprecedented spectral resolution of a F-Trp-bearing protein by 2D 19F-13C NMR!
ALT First tryptophan-based 19F-13C 2DNMR spectrum. Apo FAcD (red), substrate mimetic-bound FAcD (blue)
ALT Allosteric transmission network between allosterically coupled tryptophan residues in FAcD.
Congrats to Motasem in the #Prosserlab and our recent co-supervised alumnus @geordifrere for publishing a new story on tryptophan-based 2D 19F-13C NMR in @rsc_chembio!
Excited to share our new paper in @rsc_chembio on improving resolution in fluorotryptophan protein NMR by expanding into the 13C dimension! We prepared & used a 13C-labelled F-Trp precursor to achieve unprecedented spectral resolution of a F-Trp-bearing protein by 2D 19F-13C NMR!
ALT First tryptophan-based 19F-13C 2DNMR spectrum. Apo FAcD (red), substrate mimetic-bound FAcD (blue)
ALT Allosteric transmission network between allosterically coupled tryptophan residues in FAcD.
We're hiring a #Postdoctoral Fellow in #medicinalchemistry in collaboration with @HDAXtx! Please repost and apply below if you're interested in advancing our novel small-molecule therapeutics!
#chemjobs #chempostdoc #postdoc #postdocjobs @ChemPostdocBot
linkedin.com/jobs/view/39929…
Gunning Group retweeted
pharmacophore-optimized photoaffinity fragments-based hit discovery with improved hit rate and better sensitivity, and multiple binding sites, reported by @keserulab @GunningLabUofT
nature.com/articles/s42004-0…
Congratulations to our Sr. Researcher Associate @GeletuMulu for receiving the Rosemary Brown Outstanding Mentorship Award at @CanBlackSci's #BlackExcellenceInSTEMM conference!! Mulu's commitment to scientific mentorship in our community is nothing short of inspiring.
#BESTEMM2024
ALT Mulu Geletu receiving the Rosemary Brown Award for Outstanding Mentorship
Delighted to congratulate Dr. @geordifrere for defending his PhD thesis on the design of #monovalent electrophilic protein degraders & novel probes for protein-observed 19F #NMR! Geordi is an expert synthetic chemist & our resident scientific lectiophile!
#PrOFNMR #covalent #TPD
You can read more about Geordi's graduate journey by reading @TheMediumUTM's article featuring him! He discusses his path towards chemistry, describes the joy and wonder of creating new molecules, and shares some advice for prospective graduate students.
xitter.cf/GunningLabUofT/status/…
Our PhD student @geordifrere was featured in the latest issue of @TheMediumUTM! Geordi is a talented medicinal chemist in our lab working on the development of covalent protein degraders as well as new ways to enable site-selective ligand discovery by NMR!
themedium.ca/genesis-of-a-pa…
Geordi has been a pillar of our lab and the larger @UTM community in many capacities throughout his graduate studies. We wish him the absolute best as he heads to @harvardmed to pursue an exciting postdoc in the @GygiLab @HarvardCellBio! #gunningalumni