Professor for Genetics interested in chromatin structure, histone variants and histone modifications. Active account: @hake-chromatin.bsky.social
Gießen, Hessen, Germany
Joined February 2019
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- Following1.4K
- Followers2.2K
- Likes3.6K
Sandra Hake retweeted
Dear #Epigenetics Friends & Colleagues – Do YOU know where your histones are?
Our Xmas prezzie to the community (and perfect holiday reading): we went hunting for #histones and found them in all sorts of weird and wonderful places.
We report here 👇 journals.biologists.com/jcs/…
Sandra Hake retweeted
My lab has been working for the past 15 years to develop a method to isolate specific genomic loci to identify its chromatin composition & protein interactome. Finally,… our superb physician/scientist Dr. Bercin Cenik @bkcenik did it and here it is cell.com/molecular-cell/full… Not only was she able to develop this method, which she calls TurboCAS, she was able to identify known & novel regulators of heat shock & Myc expression. Cannot wait to see what Bercin and TurboCAS will discover about the molecular basis of transcriptional regulation with great impact on clinic in the next few years! @NU_BMG_SQE @NUFeinbergMed @MolecularCell
Sandra Hake retweeted
Deeply honoured to receive this year's Gateff Prize by the German Genetics Society @GfGenetik 🎓🧬
Recognition for an incredible team I had the privilege to work with during my PhD. @tcgcambridge @CamVetSchool @sangerinstitute @emblebi @ResearchMenzies
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Sandra Hake retweeted
Heute konnte ich an der Universität Gießen über die Entwicklung der globalen Forschung nach der US-Wahl sprechen. Danke für die Einladung!
Sandra Hake retweeted
Our new study, initiated by an undergraduate in the lab, was set to examine the effect of mutating histone H3.3 K122 to alanine. To do so, we attempted to generate murine ES cells mutating all four alleles, but were surprised when we couldn't generate these lines!
ALT model for H3.3K122A
Sandra Hake retweeted
📖 New review in Nature Reviews Cancer on how epigenomic heterogeneity drives tumour evolution! We dive into: Check it out if you're into epigenetics, single-cell tech, or the future of cancer therapy! 📖
nature.com/articles/s41568-0…
Sandra Hake retweeted
7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Sandra Hake retweeted
Thanks to everyone joining our symposium “Quiescence from a Chromatin and RNA perspective” at @jlugiessen — especially our guest and local speakers! Many fruitful discussions and exciting keynote by @keisuke_goda! Looking forward to establishing a new training network @FB08_JLU
Sandra Hake retweeted
Two papers based on my PhD work came out the same day!!
1- Large-scale study mapping the RNA-binding sites of C2H2-zinc finger proteins and other RBPs!
authors.elsevier.com/a/1joCM…
2- Role of ZBTB48 in m6A regulation!
doi.org/10.1186/s13059-024-0…
Sandra Hake retweeted
I am very pleased to share our recent study on prokaryotic histone structure and diversity nature.com/articles/s41467-0… Great work by PhD student @SammyBoterhammy. With @aimeelboyle, @Vikram_Alva, Birte Hernandez Alvarez, Yimin Hu, @MPI_Bio, @LeidenScience
Sandra Hake retweeted
We first saw evidence for this ~ 2019.
We were super surprised & skeptical.
After 5 years of quintuple cross-validation, we feel confident to share with the world.
We report many proteins not predicted by the genetic code.
They are stable & abundant O( 10³ ) copies / cell.
Generative mechanisms include codon-anticodon mismatches & RNA modifications.
Their abundance depends on codon frequency & protein stability.
biorxiv.org/content/10.1101/…
Sandra Hake retweeted
POSTDOC OPPORTUNITY TO JOIN US!
Are you interested in how nuclear metabolism impacts on chromatin function and gene regulation in leukemia?
Apply for an attractive postdoc position with us through the MSCA @carrerasleaders program!
More info here: buschbecklab.org/join-us/
Sandra Hake retweeted
Chromatin scientists, want to reorganize genomic loci as you wish?
Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/S0092…
Sandra Hake retweeted
📢ACCESS DENIED!!
Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited?
Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to SWI/SNF chromatin remodelers to prevent unraveling of nucleosomes, which enforces gene silencing and maintains high H3K9me3 density required for epigenetic inheritance
#epigenetics #heterochromatin #histones #chromatin
Congratulations to @rakesh_k_sahu and other lab members!
cell.com/molecular-cell/full…
Sandra Hake retweeted
The Genome Biology Dept @EMBL
is recruiting - independent group leader (PI) position.
We are interested in people addressing important Qs in the broad area of Genomics in creative ways - including AI, #ArtificialInteligence #jobs
embl.org/jobs/position/HD026…
embl.org/jobs/position/HD026…
Sandra Hake retweeted
Congrats Kimura-kun and Hirai-kun! Incorporation of H3E97K induces defective H3K27me3 deposition and linker histone binding. This single mutation affects chromatin structure tremendously. Very interesting!
Our new paper about nucleosome containing H3E97K mutation is published! This mutation is found in cancer cells.
onlinelibrary.wiley.com/doi/…
Sandra Hake retweeted
🚀Super happy that our latest research has finally been published in @NatureNeuro! We delve into the world of human neural development. Our findings shed light on the dynamic epigenetic changes that guide cell fate from pluripotency to fully differentiated neural cells.🧠🔬🧵
Sandra Hake retweeted
Wow! 🤯
What if we could universally recombine, insert, delete, or invert any two pieces of DNA?
In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
Sandra Hake retweeted
📢 How do H2A.Z and its chromatin depositor SRCAP regulate transcription ?
Dissected in the opus Magnum of super-talented @TollenaeArmelle, + Cédric Deluz, in collab. with @enes_ugur0 and Heinrich Leonhardt biorxiv.org/content/10.1101/…
A short 🧵
Sandra Hake retweeted
Proud to be part of this Excellence Cluster for Heart and Lung Research. Watch the movie learn about the vision and passion of the work. 🧪🩸❤️🫁🔬 @CPI_ExStra #science #maxplanckinstitute #research #heartandlung
