San Antonio, Texas
Joined November 2015
- Tweets154
- Following67
- Followers327
- Likes72
The Harris Lab retweeted
So excited to share our latest work with Sarat Chandarlapaty, @antoniomarraMD, Andrea Gazzo @MSKCancerCenter out today in @NatureGenet! We uncover the function and mechanism of APOBEC3-driven therapy resistance in breast cancer. 🧵 1/
nature.com/articles/s41588-0…
The Harris Lab retweeted
🚨 APOBEC3B (A3B) is a major source of🧬mutation in cancer
The active site is like Teflon (not much binds) BUT @Ozlem__Dmr discovered a druggable allosteric site 👀
Experiments by @DanHarki @_ChemKat @HarrisLabUTHSA 💪
biorxiv.org/content/10.1101/…
The Harris Lab retweeted
What a great way to start the day. This superb work from the Pillai lab, driven by Prajwal Boddu and a little help from us @bdelapenavalos is finally in print @MolecularCell Highlight: SF3B1 oncogenic mutations reduce RNAPII gene-body elongation rate. sciencedirect.com/science/ar…
The Harris Lab retweeted
We thank our program committee for creating a great #SABCS24 lineup.
@VKaklamani @CarlosArteagaMD @BalkoLab @tperrybrown @heide_ford @HarrisLabUTHSA @TariKingMD @lab_kok @Adrianvlee @itsnot_pink @hmcarthur @dapattmd @c_sotiriou @atanmdlci @NeilVasan @adawaksmd @awolff @AACR_CEO
The Harris Lab retweeted
📣 Hot off the press! @NAR_Open
Delighted to share our latest work!
Thanks to all collaborators and contributors.
Fresh off the press! The protein phosphatase EYA4 promotes homologous recombination through dephosphorylation of Y315 on RAD51. Hardest research paper since my postdoc years! Thx team! @bdelapenavalos @RTropee @DuijfLab @JeanYvesMasson @leunglaboratory academic.oup.com/nar/advance…
The Harris Lab retweeted
Excited to share that our paper was officially published in Molecular Cancer!👇
Read more about EYA4 and its role in promoting breast cancer progression and metastasis here: rdcu.be/dnzkx
A big thanks to @dray_lab and fantastic collaborators @RTropee and @DuijfLab.
The Harris Lab retweeted
Happy to share our last findings on HCMV evasion of APOBEC3 restriction!🤩
Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism | Journal of Virology journals.asm.org/doi/10.1128…
The Harris Lab retweeted
The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to the present day. elifesciences.org/articles/8…
ALT A superposition of the three highest-ranked protein-protein docking models of the KSHV ORF61-A3Bctd complex in pink, yellow and blue, generated using RosettaDock
The Harris Lab retweeted
My 1st first-author manuscript is out in @eLife! This project started back in 2019 with the question “what makes a viral protein evolve a new function?” A thread:
doi.org/10.7554/eLife.83893
The Harris Lab retweeted
Excited that my first co-first author paper was officially published today on mSphere!
Read more about APOBEC3B nuclear localization here: journals.asm.org/doi/10.1128…
The Harris Lab retweeted
"It is well-written, well-organized, and well-referenced, and will be of interest to readers who study APOBEC3s, herpesviruses, and host-virus arms races more generally."
Rev #1
"Molecular differences in APOBEC3 counteraction by primate herpesviruses reveal an evolutionary link between the genesis of APOBEC3B and novel viral ribonucleotide reductase function"
#RefereedPreprint
@sofianmoraes, Reuben Harris et al
eeb.embo.org/doi/10.1101/202…
The Harris Lab retweeted
More signs that Paxlovid resistance may be on the horizon
biorxiv.org/content/10.1101/…
biorxiv.org/content/10.1101/…
The Harris Lab retweeted
Something else we don't know @EricTopol:
How long will #Paxlovid remain a viable #SARSCoV2 therapy?
Our new @biorxivpreprint w/ @HarrisLabUMN @fiona_chembot shows transmissible variants already w/ resistance to multiple clinical protease inhibitors
biorxiv.org/content/10.1101/…
Quick summary on BA.4/5 variants @bmj_latest bmj.com/content/378/bmj.o196… by @emahase_ w/ @chrischirp @SGriffin_Lab @PeacockFlu
<-Key point on identical spike for these 2 variants but marked growth advantage for BA.5, shows how little we know about non-spike effects
The Harris Lab retweeted
Last month I bought plane tickets home as a self imposed deadline to finish writing my FIRST first author manuscript. Very excited (and relieved) to share that the strategy worked! 😭 Looking forward to a triumphant landing and grandma’s food biorxiv.org/content/10.1101/…
The Harris Lab retweeted
President Biden reignites the Cancer Moonshot. Learn more here: ow.ly/SpUT50HKCBG
The Harris Lab retweeted
Only 2 weeks left to register for the in-person 2022 Deaminet meeting in Palm Springs, California. There are already 25 confirmed exceptional speakers to talk about APOBEC, ADAR, and base editing! There are still a few talk slots available!! cancerresearch.uci.edu/deami…
The Harris Lab retweeted
R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B biorxiv.org/cgi/content/shor… #bioRxiv
The Harris Lab retweeted
Excited to share this preprint of the work led by Dr. Nadine Shaban where we report a cryo-EM structure of EBV ribonucleotide reductase in complex with A3B! This is the first structural explanation for a non-ribonucleotide reducing role for RNRs in biology biorxiv.org/content/10.1101/…
The Harris Lab retweeted
Best first tweet ever!!! I'm beyond honored to join the @HHMINEWS #GilliamFellows community. From Brazil to the Midwest - it's been a journey! 🥶
I'm so excited to learn from this amazing group of people and work together to continue pushing science forward! So proud of us!💚
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The Harris Lab retweeted
Today is World Cancer Day. Along with our @BigTenCRC collaborators, #UMNCancer is working to end cancer once and for all through research, clinical trials, and prevention.
#WorldCancerDay #BIGTENvsCancer