Genetic of cardiovascular diseases Post-Doc Fellow @Cambridge_Uni @DPHPC 🇬🇧 PhD @universitelaval @IUCPQ 🇨🇦 MSc @univ_paris_cite @lvts🇫🇷 From 🇫🇷/🇱🇰
Paris, France
Joined March 2011
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Wow!!! Many Thanks to @JeanetteErdmann, @konradtsawicki and @Circ_Gen for highlighting all the major points of our paper through this video!
⚡️ Now online from Thériault + team: A Polygenic Risk Score for #CoronaryArteryDisease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men ahajournals.org/doi/10.1161/…
@AHAScience #AHAjournals #CardioGen
🎬 @JeanetteErdmann @konradtsawicki
Hasanga Manikpurage retweeted
📣New from Zamani et al!
📄Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets
🫀🧬
👉bit.ly/43bMPBU
📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @CommsMedicine. We benchmarked a set of PGS for CV traits available from the @PGSCatalog resource in different Canadian cohorts🇨🇦.
See more 👇🏽 - Link (OA):
nature.com/articles/s43856-0…
(1/5)
- CAD-PGS is associated with the extent of coronary artery damage observed.
- In this study, not all CV-PGS are associated with the severity of CAD; lipid-PGS are.
Thank you to all colleagues involved in this project, supervised by Dr. S. Thériault. Thank you also to all scientists and participants involved in @_CARTaGENE_ , @clsa_elcv and Biobanque de l’@IUCPQ.
Hasanga Manikpurage retweeted
In patients with calcific aortic valve stenosis, lipoprotein(a) levels predict a higher risk of valvular and cardiovascular outcomes. #AHAJournals @HasangaDM @ClavelLabo @PPibarot @ArsenaultBenoit ahajrnls.org/4iqZYxj
Hasanga Manikpurage retweeted
2⃣Bridging genomics, transcriptomics, proteomics, and metabolomics
In a rare combination of all 4 major omics layers, this study offers a great resource for dissecting the links between genetics, expression/slicing, molecular traits and disease risk
🔗nature.com/articles/s41588-0…
📊summ stats: intervalrna.org.uk/downloads…
Hasanga Manikpurage retweeted
The common IL6R p.Asp358Ala missense variant is associated with 5% ↓odds for CAD (inhibiting pathway validated & more inhibitors in RCTs), & 5% ↓odds for rheumatoid arthritis (w approved inhibitors for pathway).
New study shows even greater (10% ↓odds) for AAA.
ahajournals.org/doi/full/10.…
Finally! Happy to share my 3rd PhD paper, now published in @ATHjournal! 🚀 This study explores the impact of integrating multiple independent lipid PRSs with a CAD-PRS for CAD incidence prediction in @uk_biobank.
👉🏽Link (Open Access! 📖): atherosclerosis-journal.com/…
Work supervised by Dr. Sébastien Thériault
With many great contributors: @Jebou326, @egagnon_phd, @gobeil_emilie, @girard__arnaud, @YohanBosse, @ArsenaultBenoit and many others that don't have a twitter handle -
From @IUCPQ, @universitelaval
Hasanga Manikpurage retweeted
Great collaborative work spearheaded by @DrMArdissino @aidanbutty showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events ahajournals.org/doi/10.1161/… @Circ_Gen
Hasanga Manikpurage retweeted
Lipoprotein(a) is an independent predictor for long-term in-stent restenosis and should be considered in the evaluation of patients undergoing PCI.
academic.oup.com/eurjpc/arti…
@escardio @AboyansV @SilCastelletti @PeroneFrancesco @andreagallardo #cvprev
Hasanga Manikpurage retweeted
London -> Barcelona by train ✅ (surprisingly easy! 🚄)
Just arrived for the 2024 @nextflowio Summit, very excited to be delivering the keynote tonight on this mildly intimidating stage (tech tests ✔️, Segrada Familia ✔️ … we’re ready to roll)
Hasanga Manikpurage retweeted
Probably the most important paper I will ever write link.springer.com/article/10… @stevesphd @BMCMedicine
Hasanga Manikpurage retweeted
The catalog of all possible SNVs altering existing upORFs or creating new ones (via both canonical and non canonical TIS) in human transcripts is available on the mobidetails platform (
mobidetails.iurc.montp.inser…) @soukarieh_omar @BPH_Research @univbordeaux_EN
Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs ... biorxiv.org/cgi/content/shor… #biorxiv_bioinfo
Hasanga Manikpurage retweeted
Our new study published in @NatureComms, led by Ghislain Rocheleau and team.
Using TOPMed WGS data, estimate heritability of CAD is 34%.
Ultra-rare variants with low LD score contribute ~50% of the heritability.
Enrichment in several functional processes.
nature.com/articles/s41467-0…
Hasanga Manikpurage retweeted
>5000 Polygenic scores now available at PGSCatalog.org! As of today's release we've broken 5k PGS, indexing data from 673 unique publications. A big thank you to the authors submitting their data and our team in pursuit of #openscience, #FAIRdata, and reproducibility!
Hasanga Manikpurage retweeted
Fantastic @Nature News Feature by @AnilOza16-
Why does heart disease affect so many young South Asians?
Highlights our ambitious goals with @ourhealthstudy & others like @masala_study.
nature.com/articles/d41586-0…
💜 ourhealthstudy.org/ 💜
@HeartDocSadiya @alka_kanaya @NammiKan
