PHC1alpha is setting off vibes of importance, not sure what it is yet.
Could muscle mitochondrial stress be the spark that drives whole-body health adaptation? This review synthesizes evidence for cell-nonautonomous signalin and flags open questions on specificity, epigenetic durability, and dose-response.
sciencedirect.com/science/ar…
Something to read, YDY🤓
frontiersin.org/journals/sci…
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Hot off the press! Homocysteine issues, are you a MTHFR SNP phenotype? Ya might want to find out. Thanks Kell and team.
preprints.org/manuscript/202… update on preprint with @resiapretorius about #homocysteine #pwLC #pwME #TeamClots
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MO retweeted
A very important review: Pulmonary vascular abnormalities in Long COVID: a radiological perspective | micro-thrombosis, endothelial dysfunction and maladaptive angiogenesis as key drivers of pathology
#LongCovid share.google/svJlTqmvPqEVz49…
MO retweeted
A Comparison in Short Term Outcomes of Coronary Artery Bypass Grafting Surgery between Post-COVID and Non-COVID Patients
🚨So AGAIN, Post-COVID patients after bypass surgery suffer nearly DOUBLE the arrhythmias (48% vs 26%) and kidney injury (38% vs 16%), plus days longer on the ventilator and in ICU. Prior COVID is not ‘just a cold’ for cardiac surgery!🫀
➡️An interesting small comparative observational study(July 2024 to June 2025, 100 patients with CAD were included, half of them had no previous history of COVID-19 infection (group A), other half had history of covid-19 infection (group B)).
➡️Key findings:
- Post-COVID patients had significantly higher rates of cardiac arrhythmias (48% vs. 26%, p=0.023) and acute kidney injury (38% vs. 16%, p=0.013).
- They also required longer mechanical ventilation (11.8 ± 5.2 vs. 7.1 ± 4.7 hours), ICU stay (6.9 ± 2.2 vs. 4.9 ± 2.4 days), and postoperative hospital stay (10.6 ± 3.3 vs. 8.4 ± 1.8 days) , all p<0.001.
- Re-exploration (10% vs. 2%) and mortality (8% vs. 2%) were numerically higher but not statistically significant.
➡️Post-COVID patients undergoing coronary artery bypass grafting(CABG) may be prone to experience worse short-term outcomes and face longer recovery periods!
‼️So, prior COVID-19 leaves a measurable residual burden: even after recovery, these patients face substantially higher rates of serious postoperative complications and markedly prolonged recovery after CABG. The physiological impact is clearly not trivial.
‼️IMPORTANT: Results are consistent with the broader literature on residual COVID-related vulnerability in the perioperative cardiac surgery setting, especially regarding recovery duration and certain organ-specific complications!
#AvoidSars2 #AvoidReinfections
banglajol.info/index.php/MED…
MO retweeted
The largest and longest study to date (18.3 million adults) tracking the relationship between COVID-19 and neurodegenerative disorders found that contracting COVID-19 SIGNIFICANTLY increases the risk of developing cognitive impairment and dementia.
🔗👇🔍
We may run out of lithium, may have to eat cars, says Blondie( Rapture call back), Thanks for the post htw!
Molecular mechanisms of lithium neuroprotection in Alzheimer’s disease: A systematic comprehensive review
sciencedirect.com/science/ar…
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Eating CARS???
Blondie - Rapture HD youtu.be/SIRG0QOEkyM?si=Zmts… via @YouTube
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MO retweeted
Persistent viral, bacterial, parasite & other #infections are increasingly implicated in chronic diseases and aging
We’ve united the top scientists, biotech innovators, and other stakeholders working to study & treat these infections into a 3-day Summit.
Come watch the talks virtually at the link below! 👇
We’re pleased to announce the inaugural PolyBio Convergence Summit will take place this November 18 to 20.
Presentations will explore the latest advances in persistent infections and their emerging roles in conditions such as Long COVID, chronic Lyme disease, multiple sclerosis, Alzheimer’s, and aging. Discussions will focus on the practical challenges that must be addressed to translate these discoveries into validated diagnostics, clinical trials, and effective therapies.
Add the virtual schedule to your calendar here: calendar.google.com/calendar…
MO retweeted
The strongest immune trace of long COVID in the blood isn't a flare up of inflammation. It's a brake left pressed down. A new study finds the clearest immune signal in LC is raised IL-1RA, the body's own off-switch for interleukin-1 (one of inflammation's main alarm molecules).🧵
Long COVID shows IL-1 pathway dysregulation without a discrete circulating biomarker signature. Most soluble biomarker differences primarily distinguished previously infected from uninfected controls rather than PWLC from recovered. frontiersin.org/journals/imm…
MO retweeted
Findings demonstrate that BBR enhances PINK1/Parkin-mediated mitophagy and PGC-1α-mediated mitochondrial biogenesis by activating AMPK, ultimately restoring mitochondrial function in CAG.
sciencedirect.com/science/ar…
MO retweeted
Lying on a vibrating mattress for 40 minutes, combined with taking two pills that release nitric oxide into the body, enhanced the clearance of an Alzheimer's-related protein via the brain's waste-disposal system newscientist.com/article/259…
MO retweeted
Researchers showed that cancer cells made senescent by chemotherapy could later give rise to tumors.
The exciting part? Navitoclax eliminated these therapy-induced senescent cells!
doi.org/10.1002/1878-0261.12…
#Senolytics #Cancer
MO retweeted
Online Now: Ca2+ is an intracellular danger signal promoting STING activation dlvr.it/TW9hd3
Just some fun informative reading
Some theories with explanations
YDY
Peace
teapawt.org/i/grok/share/c2hhcmQtN…
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Just have some add ons. teapawt.org/i/grok/share/c2hhcmQtN…
Lymphatic drainage is the fastest way to get rid of a bloating belly, facial fat, and reset your body's natural detox system.
Here are 7 simple fixes to improve lymphatic flow:
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