Junco

2/2 MY FIRST RESPONSE From: Hooven, Carole Kennedy Date: Friday, January 24, 2025 at 11:24 AM To: Arwa Subject: Re: press request - the guardian - would need comment by 3:30pm EST Good afternoon Arwa— A few thoughts right off the bat, and then I’ll get back to you with better answers to your Qs ASAP. But clearly, we don’t all start out as female! And the “intersex” rate is .018, not 1.7, this [myth] has been very clearly dispelled in the scientific literature but people keep citing that inflated number. Also people with DSDs are not a third or fourth sex; sex is a reproductive category, not a gender identity or a social role, and not defined by external genitalia or hormone levels (these are traits strongly associated with sex). There are two reproductive categories, and Trump is correct that they are based on the kinds of gametes individuals are designed to produce. I assume he didn’t invoke chromosomes because he was advised that not every female is XX and not every male is XY, even in mammals including humans. The only thing that is common to every human female is that the reproductive system is designed to produce eggs (even if it doesn’t work). People with DSDs don’t like being used as political footballs and generally want their health concerns to be addressed, if necessary.  One other thing, people with “ovotestes” are exceedingly rare, and as far as I know there are no demonstrated cases of someone with this condition being able to naturally produce viable sperm and eggs. Hormonally, that would be quite a feat. Here’s a recent tweet of mine on this issue, in case it helps [below]. There are also a few pages from my book on testosterone that might be helpful, and I could send them along if you’d like. teapawt.org/hoovlet/status/1850637… [Twitter question I answered:] It is often said that female is the default gender. This is an over simplification. How would you phrase it?] [My answer:] "This is a great question. The reason people say that is because more has to go right in fetal development to develop male-typical internal and external genitalia, and to develop a "masculinized" brain. Although the female *sex* is not default, because 50% of fetuses are male (& have testes), some traits that are very strongly associated with the female sex, are, in a way, the default. The undifferentiated genitalia that males and females share very early in fetal development look like female genitalia, and the brain is, essentially by default, feminine. In the fetus, genitalia (including the internal stuff like uterus and fallopian tubes) will develop into functional female structures without any special hormone action, and the brain will not develop in the masculine direction as long as high levels of testosterone are not present. In XY fetuses, high levels of testosterone from the testes, and its metabolite DHT, are almost always present, and that is what promotes the development of typical male genitalia, like penis and scrotum rather than clitoris and labia. Testosterone masculinizes the brain to bias male psychology to promote reproductive strategies that are more adaptive for males than females. (This helps to explain why little boys like rough play more than little girls, for instance, even though testosterone levels in little kids are roughly the same in early childhood.) Developing into a typical female doesn't just happen with no other actions, of course; various genes have to be expressed, etc., so it is not a passive process, just in some ways It is more passive than what has to happen in males. Typical male development requires relatively high levels of testosterone and the metabolite of testosterone, DHT, and female-typical development will proceed in the absence of high levels of testicular hormones. But a person who has testes and produces testosterone that is received by the body is still male (designed to produce sperm), even if some of his reproductive structures don't develop in the typical male direction. That would be considered a male disorder of sexual development (DSD). And obviously this developmental pathway says nothing about the agency or power of women or female sexuality or women's status in society. Some people don't like this narrative because they think that people misinterpret or weaponize it to uphold the "gender status quo" or they believe it actually suggests that women are somehow "less than." Obviously, that's not true. And whether mechanisms of early development are relatively "passive" or "active" is irrelevant." Best Carole SECOND RESPONSE On Fri, 24 Jan 2025 at 12:16, Hooven, Carole Kennedy wrote: Onto “scientific merits”: Correct statements from the EO: There are two sexes Humans cannot change sex (but they can change sex-associated traits, like beards, breasts, hormones, voice, behavior, dress, etc.) Sex is not a synonym for gender identity (and GI does not have a clear and consistent definition, like sex does…or, did, until very recently) Girl and women: juvenile and adult human female, respectively The sex that produces the small reproductive cells (gametes) is female, that which produces the large ones is male. Women are biologically distinct from men. NOTE: obviously current or fully functional production of these cells is not what defines sex; it is something like the “design plan” of the organism, in this case humans, to produce one gamete type or the other. (Boys and girls don’t produce sperm or eggs, but they are still male and female. I’m no longer producing eggs, but I’m still female. Etc.)  This begins with the differentiation of the bipotential gonad (can develop into testes or ovaries, depending on what genes are expressed) very early in embryonic development, around week 6. If the Y chromosome is present, testes develop; without the Y, ovaries develop. After testes develop, they secrete testosterone & DHT (those are androgens that stabilize and develop the precursors to male internal (and external) genitalia, & anti-Müllerian hormone (AMH) which causes the precursors to the female internal genitalia to regress. Some people think—because testosterone and DHT are necessary for male-typical development of the internal and external genitalia, and female-appearing genitalia will develop essentially by default, without those (or any) hormones—that female is the default sex. But it isn’t. In mammals (including humans) sex is determined not by sex hormones but by chromosomes. That is, the presence or absence of the Y chromosome (and the SRY gene it contains and the protein it codes for). That causes the development of testes rather than ovaries, and that’s male, not female development. This is true even if in some rare cases the clitoris looks like a penis  in a female or there are remnants of some internal female-typical genitalia in a male. Statements from the EO not supported by evidence: One’s “internal, fluid, and subjective sense of self [is] unmoored from biological facts.” I think this is supposed to mean that one’s sense of one’s sex can be dissociated from the fact of one’s sex, and this would be true. However the way it’s written suggests that the way one feels about their sexed body, and how they feel in that body in a society with different cultural norms and expectations for each sex, has no biological underpinnings. But the way we feel about our sex, our bodies, and social expectations based on our sexed characteristics, are all connected to our sexed biology; whether that biology is genes, hormones, or their effects on breasts, body size, face shape, voice, masculinity, femininity, etc. The interaction between biology and culture profoundly affects how we feel about ourselves in society. That was a long way of saying that biological facts, like having large breasts or big muscles or high testosterone or high estrogen, all profoundly affect our “subjective sense of self” in society. SO, I think this section could have been written more clearly, and perhaps, with a touch of compassion for people who feel uncomfortable with the social expectations for their sex. I think that kind of language also would help people appreciate that the recommendations, as far as recognizing the reality of two sexes and basing policy on science, evidence and facts rather than ideology, are welcome changes. [While I do have some concerns about the tone of the EO, I later asked Arwa to delete it because I thought my personal comments were inappropriate and that I should just stick to the facts.] Please let me know if you have any other questions, and send me quotes if possible...before publication. And good luck with the article! Best Carole THIRD RESPONSE From: Hooven, Carole Kennedy Date: Friday, January 24, 2025 at 4:37 PM To: Arwa Subject: Re: press request - the guardian - would need comment by 3:30pm EST Hi Carole, ... [Arwa:] Just to clarify a little bit more, however, do you believe this specific definition from the EO [Trump’s Executive Order] is correct: “Female” means a person belonging, at conception, to the category of people who produces the large reproductive cell." [CH:] YES THIS IS CORRECT. But some will argue, well little girls don’t produce sex cells. But the point is that their reproductive system is designed around producing large sex cells. The EO is correct. [Arwa:] Is sex determined at conception--as this states it is? [CH:] YES!!! It’s correct. All those genes are present to be one sex or the other are present at conception, even if they have three X chromosomes and one Y. Good luck!! Carole THE END