The Hinks Lab investigate the immunopathogenesis of airway diseases and pulmonary infections.
University of Oxford, England
Joined November 2017
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The 'Dream Combo' in #EosinophilicAsthma: for those on #asthma biologics with persistent mucopurulent cough additional long term, low dose azithromycin is highly effective. Gabriel's findings from @OxfordBRC out today in thorax.bmj.com/content/early…
The new NICE/BTS/SIGN #Asthma guidelines are superb. A collaborative approach. A focus on using blood eos and FeNO at initial presentation and finally the long-overdue end to salbutamol. Read it and use it now nice.org.uk/guidance/NG245
1 million people switched from Twitter / X to BlueSky today. Come and follow us there, now on @hinkslab.bsky.social
Out today doi.org/10.1016/j.mucimm.202… our collaborator Adam Byrne shows airway macrophage glycolysis controls lung homeostasis and responses to aeroallergens. Exposure to house dust allergen drove glycolysis in alveolar macrophages; inhibiting this altered inflammation, via TLR2.
When exacerbations of severe #asthma occur despite being on type 2 biologics, what residual inflammation remains? In our latest paper from @OxfordBRC we show prednisolone caused broad down regulation of type 2 pathways in pts on mepolizumab.
Full report: doi.org/10.1016/j.jaci.2024.…
Our new species-level study from @OxfordBRC shows severe #asthma microbiome is dominated by H. influenzae, M. catarrhalis and S. pneumoniae, driving
neutrophilic inflammation, airway proteases and disrupting regulatory immune responses:
doi.org/10.1111/all.16269
A 2 minute summary of our unexpected finding from @NDMOxford of tonic type 2 signalling in the airway mucosa in health. youtube.com/watch?v=inNYVjd-… funded by @asthmalunguk
Out today: an unexpected discovery from our Leicester/Oxford healthy volunteer bronchoscopy study. In health there is constitutive type 2 signalling within the airway mucosa, which is exquisitely sensitive to ICS. Read it now in doi.org/10.1111/all.16146
Want to find out more about azithromycin in acute and chronic respiratory disease? Join our ERS webinar on 14th May ersnet.org/events/azithromyc…
How can we help the 2/3 of people with a high FeNO who aren't using their inhalers adequately? As Fostair NEXThaler counter only triggers at an adequate inspiratory flow rate, the Leicester group have used dose counting with FeNO to detect non adherence. doi.org/10.1016/j.jaip.2024.…
