Ovarian biology lab led by Prof Karla Hutt | @MonashBDI | @Monashuni | Reproductive biology | Infection & Inflammation | Oncofertility | Cake enthusiasts
Monash University
Joined September 2019
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Out now in @RBMOnline Outcomes of assisted reproductive technology cycles following bushfire exposure: a retrospective cohort study #climate #fertility 🔥🌏🧫 doi.org/10.1016/j.rbmo.2025.…
Hutt Lab retweeted
I recently spoke to @FaScienceLabs (linktr.ee/familysciencelabs) about the contributions of environmental and lifestyle factors for healthy reproductive function and #fertility🌏. Check out the #podcast on here on #Spotify: open.spotify.com/episode/14n… or #YouTube: youtube.com/watch?v=rMPLGE1N…
Hutt Lab retweeted
Congratulations @DrLaurenAlesi from @HuttLab @MonashBDI on being awarded a Cancer Council Victoria @CancerVic Postdoctoral Fellowship in 2025 to study new means to improve fertility preservation for cancer survivors
cancervic.org.au/downloads/r…
Hutt Lab retweeted
Thank you to @EMBLAustralia for the opportunity to take part in the annual PhD course this year! I had such a fun time networking and learning alongside the other students & researchers! 🔬🧪🥼👩🏽🔬
#EMBLAPhD
Thanks to @ReproductionSRB @ESASRB for another amazing conference! Lots of EGGciting work to be inspired by 😉 See you all in Perth next year 🔬@Jordan_H193 @DrLaurenAlesi @Tony_Nguyenn11 @Yasmin_Lewis1 @ZaahidaShireen @SaranyaGiridha2
Hutt Lab retweeted
Thanks to @ESASRB @ReproductionSRB for the opportunity to present some of my work! Great conference with even greater people. Looking forward to the next 🤓🥳 #ESASRB #SRB2024 #endometrium @DrLaurenAlesi @Yasmin_Lewis1 @Tony_Nguyenn11 @ZaahidaShireen @SaranyaGiridha2
Hutt Lab retweeted
I was extremely fortunate to be able to present my work at @ESASRB @ReproductionSRB again. Such great work is happening in the reproductive field. I can't wait for next year!
Hutt Lab retweeted
Thank you to @ReproductionSRB @ESASRB for the opportunity to present this year! I’ve had the best time meeting and learning from other researchers 🥰 I can’t wait for the next meeting 👩🏽🔬❤️
Congratulations you our newest lab PhD graduate, @DrLaurenAlesi! Such a joy to work alongside you and watch your growth and development over the years, into a thriving postdoc 👩🎓 @KarlaHutt @amy_winship @JM_Stringer
More evidence to suggest environmental factors impact on health & fertility in @ConversationEDU by @amy_winship & @mpgreen13
A new study has linked traffic noise and pollution to infertility - but the effects differed for men and women 🌍 @mpgreen13 @HuttLab @ReproductionSRB
theconversation.com/a-new-st…
Hutt Lab retweeted
Excited to share our new review (my first paper in Edinburgh!), online now in @TrendsMolecMed summarising recent advances with potential to accelerate diagnosis and improve care for endometriosis sciencedirect.com/science/ar…
Hutt Lab retweeted
It's always a pleasure to represent the @HuttLab at #ARU! We were blown away by the amazing science today and can't wait for Day 2 of the Greatest Show 🪄
#ARU2024 @amy_winship @Jordan_H193 @Tony_Nguyenn11 – at Melbourne, Victoria
Together, our data demonstrate that BRCA1 is a key regulator of oocyte number and quality in females and suggest that caution should be used in relying on AMH as a reliable marker of the ovarian reserve in this context.
Given the critical role of the BRCA proteins in mediating DNA repair, our data extend current knowledge of quality control mechanisms in the germline & lay foundations for future studies to test specific effects of genotoxic insults on oocytes in context of loss of BRCA1. 🧬
AMH levels were not predictive of reduced primordial follicle number in Brca1 cKO mice vs WT. Furthermore, we found no correlation between follicle number or density and serum AMH concentrations in matched samples from a small cohort of premenopausal women with BRCA1/2mutations.
We also aimed to determine utility of serum anti-Müllerian hormone (AMH) - gold-standard indirect marker of ovarian reserve used in clinical practice - as a marker of ovarian function, by assessing🩸 levels in mice & women with BRCA1 mutation & correlating with follicle counts.
Conditional loss of Brca1 in oocytes led to reduced litter size in mice 🐭 From comprehensive follicles counts, ovarian reserve was ⬇️ & oocyte maturation impaired by 45% with advanced maternal age in mice.
We aimed to address a longstanding question in the field regarding the functional consequences of BRCA1 inactivation in oocytes❓To do this we generated mice with conditional gene deletion of Brca1 in oocytes using Gdf9-Cre & we confirmed complete knockout in eggs. 🥚