I’m looking forward to moderating the panel “AI-enabled Next-Generation Targets in Neuro Aging” at the 13th @ARDD_Meeting
One of the most interesting questions in aging research is whether AI can help us move beyond the targets we already know - surfacing mechanisms hidden within complex biological data and translating them into testable therapeutic hypotheses.
That question is especially relevant to my own work. Earlier this year, my collaborators and I introduced the Decoherence via Demyelination Hypothesis (DDH), which proposes that an important component of cognitive aging may arise not simply from neuronal loss, but from progressive disruption of the timing and synchronization of distributed neural networks as myelin integrity declines.
More on the theory: DDH-theory.com
At the Aging Research & Drug Discovery Meeting I’m looking forward to a broader discussion about where the next generation of neuro-aging targets will come from, how AI may change the way we discover them, and how we distinguish an interesting computational signal from a biological mechanism worth pursuing experimentally.
Friday, October 2 | 2:40–3:20 PM
David Rubenstein Treehouse at Harvard University
20 Western Avenue, Allston, MA 02134
ARDD 2026: agingpharma.org
If you’ll be at ARDD, I hope you’ll join us.
#ARDD2026 #AgingResearch #Neuroscience #DrugDiscovery #AI #Longevity #DDH
iosif retweeted
From CAR T cells to bispecific antibodies, we cover all of immunology in the war on cancer! #immunologymatters #changingwhatspossible
ImmuVia will present new data on IMV-M™ (MUC16xDR5 bispecific) at the 17th World Bispecific Summit on September 17th.
@HansonWade was kind enough to publish a brief interview related to our work ahead of the summit.
bispecific.com/about/blog-po…
iosif retweeted
I do not support pacing frontier models. If I am going to die at the hands of killer AI, I want it to be American, not Chinese. Buy American, Die American.
iosif retweeted
Dario has written that we need to “pace the frontier,” and Sam has agreed. People may be surprised by my response: go ahead.
You guys are the frontier. By any reasonable metric — market share, revenue growth, model capability — the two of you have a duopoly on frontier intelligence. You’ve also claimed the lead is widening because of recursive self-improvement.
I don’t see what you see in the lab. If the unreleased models are scary enough that you think you should slow down, I support your decision to be responsible.
But stop pretending you need anyone else’s permission. Stop pretending antitrust law has to be suspended so you can form a cartel. Stop pretending you need a regulatory approval process that supersedes product liability. Stop pretending METR is independent when it is intertwined with Anthropic’s investors and staff. Stop pretending you need those same evaluators to police competitors who aren’t even at the frontier.
Most of all, stop pretending the motivation to slow down is purely altruistic. You face massive product-liability exposure if your products enable a truly damaging cyberattack. The market already punishes models that behave in unpredictable or unauthorized ways. After the Hugging Face episode, it is simply good business for OpenAI and Anthropic to trade some raw power for reliability and predictability. Call it alignment if you want. It is also just giving customers what they want.
Pacing the frontier would also create breathing room for a more intelligent conversation about regulation than Bernie Sanders’ “shut it all down.” China is very unlikely to join a global agreement, as you know, and that has to be taken into account as well.
So go ahead and pace the frontier. You are the ones setting it. The easiest way not to build superintelligence is for you to agree not to build it. Demanding your preferred regulatory framework as the price of that will look like blackmail of the public and the political system. So just do it.
If you do, you’ll buy goodwill for the next conversation. If you don’t, we’ll know this was just another bid for regulatory capture — or an election-season psyop.
If the standard is set of AI exceeding the cognitive performance of the authors of the proposal then everyone using GPT-3 and beyond would be subject to their inane penalties.
iosif retweeted
Russian-speaking Jews knew all along that antizionism was a filthy, bigoted movement; after all, it was one of the forces that drove Soviet Jews out of the Soviet Union. Like all immigrants, Russian-speaking Jews met their American Jewish cousins with a mixture of admiration and disenchantment. They looked up to American Jews because they had drawn the roadmap, proof that in America, "zoological antisemitism" would not keep a Jew from succeeding. But when antizionism arrived in America, unabashed, out in the open, Russian-speaking Jews began to speak up and the disenchantment began to set in: instead of being heard, they were removed from the conversation.
There is a story waiting to be told about the American Jewish response to Soviet Jews, and in many ways it is the story of the Ostjuden all over again: the "unrefined" Eastern European Jews whom their assimilated German cousins once met with embarrassment. American Jews were proud of the role they played in freeing Soviet Jewry. But once they had arrived, carrying their aversion to Marxism, feminism, Third-Worldism, and antizionism, that pride curdled into disdain. These were the Jews of rage who did not understand the value of holding seats at venerated tables or starting emails with "circling back."
There are stories upon stories waiting to be told of how Russian-speaking Jews were met by the very people who had so enthusiastically helped to bring them to America.
Russians are an emotional people. And, irony of ironies, for a people raised under censorship, Soviet Jews do not censor themselves . They find nothing rewarding in bureaucratic language. American Jews, by contrast, are of the polite sort. As one Russian-speaking Jew put it to me on a recent visit to Melbourne, Australia: "We are told by our Jewish leadership that we are not allowed to be angry. When we show anger, our Jewish leaders punish us by removing us from the conversation."
That, in itself, is another story waiting to be told: the story of the Jews of rage. Few know that Elie Wiesel's Night began in Yiddish, as Un di Velt Hot Geshvign ("And the World Remained Silent") and was cut and reshaped almost beyond recognition on its way to the world in translation. Few publishers had an appetite for the original, a text steeped in vengeance. In English, Night is a story of redemption and renewal. In Yiddish, it is a story of revenge. Strange because somewhere along the way, diaspora Jews told themselves that to be heard, a Jew is not allowed to be angry. But other minorities? Their rage is justified. And many American Jews did more than justify it; they supported it and participated in it: the protests, the activism, and yes, the rioting.
I often ask myself: what do we Russian-speaking Jews actually bring to the table? We may know the truth, but if we cannot translate it for a culture willing to listen, what is the point?
For years we have been dismissed or vilified as "right-wingers," "reactionaries," and "racists." Do Russian-speaking Jews tend to vote conservative? Certainly. But perhaps there is a reason, and here the joke writes itself. These onion-loving, borscht-eating cousins arrived carrying the one credential our progressive culture venerates above all others: lived experience.
We do not theorize about socialism from a seminar room; we lived it. We do not debate whether antizionism is criticism of the government or if it "crosses the line into antisemitism" because we know. By every rule of progressive epistemology, we should be the most listened-to Jews in America. Instead, many are dismissed. Recently, there is a movement to shed light on antizionism. And I am glad. But I am still struggling to understand why Jews are not allowed to be angry or put their needs first.
The Djinn team is excited to partner in launching the new research track at Exploit Summit. Bittensor deserves academic study.
When the MIT Sloan Sports Analytics Conference added its research track 15+ years ago, it grew from a couple hundred attendees to many thousands.
Bittensor isn’t just a network. It’s a live economy: subnet emissions, participant incentives, yuma consensus, mechanism design and evolving token markets.
A growing number of academics are now studying how these systems behave. At Exploit, we will be hosting a research track to explore this research.
Bittensor ecosystem members are already exploring this frontier: @pmaymin is modelling options pricing and factor premia in AMM-native markets; @IMGpf and @AlexZevelev are studying Bittensor’s market microstructure and emission policy; and @HarryDCrane is quantifying activity in offshore prediction markets.
This is an open call for research paper submissions from the ecosystem.
Submit a short abstract on its markets, mechanisms, incentives or token dynamics. Selected authors will invited to present their research live at Exploit.
Work in progress and papers under review elsewhere are welcome.
Submit dates:
- Abstracts July 24th
- Full Paper August 14th
docs.google.com/forms/d/e/1F…
Winner announced: August 28th
Can't wait to read them 👀
iosif retweeted
Bittensor isn’t just a network. It’s a live economy: subnet emissions, participant incentives, yuma consensus, mechanism design and evolving token markets.
A growing number of academics are now studying how these systems behave. At Exploit, we will be hosting a research track to explore this research.
Bittensor ecosystem members are already exploring this frontier: @pmaymin is modelling options pricing and factor premia in AMM-native markets; @IMGpf and @AlexZevelev are studying Bittensor’s market microstructure and emission policy; and @HarryDCrane is quantifying activity in offshore prediction markets.
This is an open call for research paper submissions from the ecosystem.
Submit a short abstract on its markets, mechanisms, incentives or token dynamics. Selected authors will invited to present their research live at Exploit.
Work in progress and papers under review elsewhere are welcome.
Submit dates:
- Abstracts July 24th
- Full Paper August 14th
docs.google.com/forms/d/e/1F…
Winner announced: August 28th
Can't wait to read them 👀
Milestone unlocked
100 chain-anchored canonical outcomes finalized on Base Sepolia today.
Four-of-five validator quorum, EIP-712 signed, indexed end-to-end.
The settlement layer Djinn has been building toward for six weeks is now live.
Prepare for takeoff!
Replying to @bittensor
@bittensor, should a mechanism designer who already smooths noisy signals also subsidize informed traders to correct those signals? We show the two are substitutes on the allocation frontier, not complements. A decentralized network that distributes roughly $1.2 million per day across 128 competing projects operates under either a price-proportional rule or a flow-smoothed rule that averages capital flows over thirty days. A short-selling correction improves allocation accuracy by 16.5% under the price rule but degrades it by 11.5% under the smoothed rule, because the moving-average filter attenuates the correction's high-frequency content. We prove the sign-flip from automated market-maker primitives in a two-asset model and establish a separating equilibrium under a filtered variant that captures both benefits simultaneously.
Bittensor miners are getting DDoS'd.
We built a solution (djinn-tunnel-shield) and open-sourced it.
3 lines of code, zero config, Cloudflare Tunnel failover that kicks in automatically when an attack hits. Free, MIT licensed.
pip install djinn-tunnel-shield
Pair with host-level protection and subnet parameter tuning for real resilience.
Built for SN103. Open sourced for all subnets to benefit.
iosif retweeted
Mark sees it.
Jason sees it.
Even I see it 😂
Djinn is a top subnet with a bottom subnet price.
103 🔥🧞♂️
$TAO
I've been a longtime fan of the @theallinpod - happy to see @djinn_gg (@bittensor SN103) getting on the radar as we build.
@DavidSacks @chamath @friedberg @Jason





























