Postdoc at University of Oslo Interested in autoimmunity, celiac disease, RA, plasma cells, BCRs, IG polymorphisms and single-cell technologies.
Oslo, Norge
Joined April 2012
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🔔Our new PNAS study: Celiac-associated HLA-DQ2.5 doesn’t just present gluten—it preselects naive TCRs that can recognize gluten. HLA risk alleles help wire a disease-relevant T cell repertoire before antigen exposure. #TCR #celiac #HLA #immunology🧵
doi.org/10.1073/pnas.2520636…
Our results offer a new angle on genetic risk and pathogenesis in celiac disease. Which other HLA-associated diseases could be affected by skewed naive TCR repertoires?
Thanks to everyone involved in this study!
Aengus Officer, @ctwatson29, @EivindNess, Ludvig Sollid, @UniOslo, @UniOslo_MED, @Oslounivsykehus, NTNU
Ida Lindeman retweeted
Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!
biorxiv.org/content/10.1101/…
Ida Lindeman retweeted
Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease dlvr.it/T5DBjy
Ida Lindeman retweeted
Tissue proteomics with clinical value in #celiac disease: - bitly.ws/3fGa2 Great work Anette Johansen and thank you collaborators in particular @SandveGeir for expert ML knowledge! @CeliacDotOrg @UniOslo_MED @Coeliac_UK @AGA_Gastro @coliakiforening
Ida Lindeman retweeted
Very happy to share this story on autoreactive B cells in celiac disease together with @IdaLindeman @LeneHoydahl @ChristophAsb @LouiseFRisnes @JCoDiRC. Here, we identify a population of circulating IgA-switched B cells specific to the self-antigen transglutaminase 2 (TG2).
Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease biorxiv.org/cgi/content/shor… #biorxiv_immuno
Ida Lindeman retweeted
Very happy to share that our paper on anti-gluten antibodies in celiac disease is out now in @CellReports. The study was led by Chunyan Zhou @JCoDiRC @UniOslo_MED and was a great collaboration with the Buus lab @UCPH_health. Details in 🧵
cell.com/cell-reports/fullte…
Ida Lindeman retweeted
New work from our @UiO_LifeSci ImmunoLingo convergence environment in which we leverage linguistics to formalize the antibody sequence language. arxiv.org/abs/2209.12635. Work led by @MaiSpaceHa, @PRobertImmodels, @pandaisikit.
See🧵below by @MaiSpaceHa for details.
New preprint from the ImmunoLingo convergence environment: “ImmunoLingo: Linguistics-based formalization of the antibody language”. We asked: how to define the language of antibody sequences for more efficient antibody therapeutics design? 1/7
arxiv.org/abs/2209.12635
We're looking for an enthusiastic #postdoc to join the Sollid group (med.uio.no/klinmed/english/r…) at the University of Oslo through the #ScientiaFellows program to investigate genetic polymorphisms in adaptive immune receptors. Please share and DM if interested! #postdocjobs #AIRR
Ida Lindeman retweeted
We used scRNA-seq to assess the combined transcriptome and Ig repertoires of CSF B cells in MS. This revealed a stereotyped B-cell response using IGHV4/IGKV1 in patients carrying certain IGHC alleles! @EurJImmunol #MS onlinelibrary.wiley.com/shar…
Ida Lindeman retweeted
Happy to share this story on anti-gluten antibodies in celiac disease. biorxiv.org/content/10.1101/… The project was led by Chunyan Zhou @JCoDiRC @UniOslo_MED and is the result of a long-standing collaboration with the Buus lab @uni_copenhagen. Main findings are summarized below.
Ida Lindeman retweeted
Happy to share our work on multi-dimensional comparison of immune repertoires. Amazing work by @cedricrweber. Great collaboration with Xiao Liu, @ReddyLab_ETHZ, @mkuijjer, and, as always, @SandveGeir. Main findings in 🧵. biorxiv.org/content/10.1101/….
Ida Lindeman retweeted
So you ran a single-cell RNA seq experiment...now what? Ludvig Sollid @JCoDiRC and @IdaLindeman reviews single-cell approaches in the investigation of celiac disease: nature.com/articles/s41385-0… #Celiac #SingleCell
Ida Lindeman retweeted
We just released CompAIRR – a tool that reduces greatly the longstanding computational bottleneck of identifying shared identical and similar sequences among large sets of immune repertoires. All the details/links are in the thread below. Feedback is very welcome! @airr_community
We are happy to report a dramatic speedup for one of the core computations for adaptive immune receptor repertoire (AIRR) analysis - the discovery and counting of receptors that overlap between repertoires! Check out our CompAIRR method: biorxiv.org/content/10.1101/… 1/7
Ida Lindeman retweeted
Another new preprint! We combined virtually-docked 3D-antibody-antigen binding complexes with an unbiased in silico oracle to explore at unprecedented resolution the principles of ML-based antibody design with respect to affinity, conformational epitope, and developability. 1/2
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Ida Lindeman retweeted
Happy to share our preprint: "A billion synthetic 3D-antibody-antigen complexes enable unconstrained machine-learning formalized investigation of antibody specificity prediction"
biorxiv.org/content/10.1101/…
Check out Absolut! database+software to simulate more
github.com/csi-greifflab/Abs…
Ida Lindeman retweeted
Our review on "Immunoglobulin germline gene variation and its impact on human disease" is out. Great collaboration with @immuno_ivana and Ludvig Sollid @JCoDiRC. @airr_community Link: nature.com/articles/s41435-0…
