Genetics of anti-cytokine autoantibodies suggest they protect against cancer or drive metabolic disease. Pairing GWAS with seromic profiling captures the environmental triggers driving autoimmunity for critical multi-omic insights. rdcu.be/b4nyEn1C5Cha #Immunology #Genetics #GWAS #Autoantibodies #Reactomics #MultiOmics #Biomarkers #PrecisionMedicine

Can a blood draw differentiate dementias? Bellomo et al. used plasma proteomics to distinguish AD, DLB & FTD. Adding antibody reactomics yields critical multi-omic insights into environmental drivers of neurodegeneration. rdcu.be/fAFt0 #Neurodegeneration #Proteomics #Reactomics #Biomarkers #Alzheimers #Dementia #LewyBody #FrontotemporalDementia #CohortOfTheWeek #MultiOmics

How stable is the proteome? A @NatureComms cohort study reveals disease onset reshapes protein stability—locking in normally variable signals. To track these dynamic shifts & past immune encounters, pair proteomics with antibody reactomics! rdcu.be/fzmKA #Proteomics #AgingResearch #Biomarkers #PrecisionMedicine #CohortOfTheWeek

Serum autoantibodies mirror central disease manifestations in AD, PD & MS, proving neurodegeneration is systemic! Broadly profiling self, viral & environmental reactivities unlocks new biomarkers. doi.org/10.1016/j.isci.2026.… #SystemsImmunology #Neurodegeneration #Proteomics #Reactomics #Biomarkers #Alzheimers #Parkinsons #MultipleSclerosis

A new study analyzed how ancestry & geography shape biology. Integrating multiomics with antibody responses to 37 microbial antigens provided key insights into how exposure history drives biological aging. doi.org/10.1016/j.cell.2026.… #Proteomics #MultiOmics #Microbiome #PrecisionMedicine #Reactomics #CohortOfTheWeek

Plasma proteomics can track cell-specific aging, but what drives it? By adding antibody reactomics to cohorts, we can map lifetime environmental exposures (viral, bacterial). This layers critical context onto proteomics to uncover what triggers cellular aging & chronic disease. [doi.org/10.1038/s41591-026-0…] #Proteomics #MultiOmics #CellularAging #Neurodegeneration #Reactomics #CohortOfTheWeek

A landmark study in Cell uses plasma proteomics to predict lung cancer 5+ years early. While proteomics tracks inflammatory drivers of cancer, adding antibody reactomics links potential infectious and environmental exposure triggers. [doi.org/10.1016/j.cell.2026.…] #Proteomics #MultiOmics #CancerPrevention #LungCancer

Metagenomics shows which gut microbes predict Type 2 Diabetes risk. But how does the host respond? By layering antibody reactomics, we can track exactly how the immune system monitors these diet-microbe shifts, unlocking the next frontier in early risk prediction. [doi.org/10.1016/j.xcrm.2026.…]

A new Nature Aging study of 5 major cohorts (incl. UK Biobank & ADNI) reveals how APOE2 & APOE4 shape Alzheimer’s risk. Massive, diverse human cohorts are essential for capturing these novel disease mechanisms. Read more: rdcu.be/fkVs9

Most systems immunology data lacks diversity, relying heavily on European ancestry. The new HHGP-HK Asian reference cohort (1,025 donors) changes that. Diverse human cohorts are essential to address data gaps, validate biomarkers, & discover novel disease associations globally.