@IoannouLab

Cell Biologist, Neuroscientist, and Associate Professor at the University of Alberta

ioannoulab.com
Joined September 2020
  • Tweets91
  • Following356
  • Followers498
3Media
Check out ycharos.com/data/ to see the antibodies they have validated. Head to head comparison of antibodies for your fav protein. All the data is open access and they update often!

Data

Our Data YCharOS is posting all our data to Zenodo. Check out our page here. YCharOS is now posting data to F1000. As our reports are peer reviewed, they will be found

ycharos.com
Laura Volpicelli 🇺🇸@lvolpicAug 27
Dr. Peter McPherson and former mentor of mine Dr. Richard Kahn are among heroes making efforts to validate commercial antibodies so western blot, immunofluorescence etc. data can be trusted mcgill.ca/neuro/channels/new…

Open Science antibody characterization project receives $4-million

YCharOS is an independent quality assessment initiative to improve research results An antibody characterization project with partners at The Neuro will be able to expand thanks to funding from

mcgill.ca
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Layla M. Nassar and Shawn M. Ferguson @YaleMed discuss Kim et al.’s new study (hubs.ly/Q04d5drp0) showing that TMEM63A protects #lysosomes from rupture by acting as a pressure relief valve when membrane tension rises. hubs.ly/Q04d553Y0
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Julie's paper is out!!! Check out how PD mutations in GBA1 and LRRK2 drive the spread of alpha-synuclein through ectosomes!
Julie Jacquemyn@JacquemynJulieFeb 14
So excited to share our work on Glucosylceramide-induced ectosomes propagate pathogenic alpha-synuclein in Parkinson’s disease, now out @ Nature Cell Biology! @NaturePortfolio nature.com/articles/s41556-0…
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Excited to share our new study on ApoE is out!
Neuron@NeuroCellPress2 Dec 2025
Online now: Protective ApoE variants support neuronal function by effluxing oxidized phospholipids dlvr.it/TPb6LW
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Maria Ioannou retweeted
J Cell Science@J_Cell_Sci13 Oct 2025
Luis Fernando Rubio-Atonal, Maria Ioannou @IoannouLab and colleagues @UAlberta @NMHI_UofA find that glutamate decreases oxidative stress and lipid droplet formation in astrocytes. Highlight: journals.biologists.com/jcs/… Article: journals.biologists.com/jcs/…
Figure showing that glutamate increases mitochondrial oxidation of exogenous fatty acids.

ALT Figure showing that glutamate increases mitochondrial oxidation of exogenous fatty acids.

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Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations @ShanRhoads and team! 🎉doi.org/10.1016/j.celrep.202…
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ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science science.org/doi/10.1126/scie…

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox

Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic,...

science.org
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Our new preprint describing the role of ApoE2 and ApoE3-christchurch in protecting neurons from lipid peroxidation is out. biorxiv.org/content/10.1101/…

Protective ApoE variants support neuronal function by extracting peroxidated lipids

ApoE mediates the transport of lipids from neurons to glial lipid droplets. ApoE4, a major risk factor for Alzheimer’s disease, impairs this transport pathway, increasing risk for neurodegeneration....

biorxiv.org
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Thanks to @isharalhan_ @FemkeF @_jesse_jackson @alyy_dodo
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biorxiv.org/content/10.1101/…

Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson’s disease

Intercellular transmission of α-synuclein contributes to Parkinson’s disease pathology. Yet, the mechanisms of α-synuclein spread are not fully understood. Here, we used live-cell microscopy to...

biorxiv.org
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Thrilled to preprint my postdoc work in the @IoannouLab ! 🚀 Using live-cell and two-photon imaging, we reveal that Parkinson’s-linked glucosylceramide changes drive the formation and shedding of ectosomes, fueling α-synuclein spread. This pathway has broad implication in PD.
https://www.biorxiv.org/content/10.1101/2025.02.14.638390v2

ALT https://www.biorxiv.org/content/10.1101/2025.02.14.638390v2

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Maria Ioannou retweeted
James Olzmann@OlzmannLab31 Oct 2024
Please RT and help us get the word out. Scott Dixon @sjd956 and I are co-organizing the first @FASEBorg #Ferroptosis conference this summer! Awesome line up of speakers and room for additional short talks! Save the date & come join us July 27 - 31, 2025! 🤩events.faseb.org/event/11797…
FASEB Ferroptosis Conference!

ALT FASEB Ferroptosis Conference!

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Very proud of our paper with @AlquierThierry lab exploring the regulation and function of neuronal lipid droplets under basal conditions. In short, neuronal lipid droplets support the function of hunger-activated neurons to maintain energy homeostasis in 🪰&🐁/1
bioRxiv Neuroscience@biorxiv_neursci21 Sep 2024
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress nature.com/articles/s41593-0…
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Maria Ioannou retweeted
CAN ACN@CAN_ACN16 Jul 2024
Brain Star Award winner feature: Isha Ralhan | University of Alberta - How neurons protect themselves from lipids damaged by oxidative stress can-acn.org/brain-star-award… Paper in J Cell Biology rupress.org/jcb/article/222/… @CIHR_INMHA @UAlberta
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Excited to see the much anticipated Neurolipid Atlas has gone live! Congrats to @rikvanderkant and @MartinGiera. Check it out neurolipidatlas.nl
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Maria Ioannou retweeted
Martin Munz@MartinMunz212 Mar 2024
Replying to @CIHR_INMHA @ed_ruthazer @IOB_Roska
Thank you! I am very excited to start in the Physiology department @UAlberta . We have open positions for PhD students and postdocs. If you are interested, check out our lab website and send me an email! munzlab.com/

Munzlab | lab for neuronal circuits

The Munz lab is interested in how neuronal circuits form, how the resulting brain circuits function and how development and function are altered in neurodevelopmental disorders such as autism. We are...

munzlab.com
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Maria Ioannou retweeted
Zhe Wang@ZheWang_NCB1 Mar 2024
📢Latest Review @NatureCellBio:"A guideline on the molecular ecosystem regulating #ferroptosis" by Dai, @bstockwell, Kroemer, Tang and colleagues. Check it out and stay tuned for more exciting content on cell death from @NatureCellBio ! nature.com/articles/s41556-0…

A guideline on the molecular ecosystem regulating ferroptosis

Nature Cell Biology - In this Review, Dai, Stockwell, Kroemer, Tang and colleagues offer a comprehensive discussion of the molecular regulation of ferroptosis and highlight how this may be...

nature.com
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Check out our new opinion piece by @JacquemynJulie and @isharalhan_
Trends Cell Biology@TrendsCellBio23 Feb 2024
Driving factors of neuronal ferroptosis dlvr.it/T39Lsk
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The E4 variant of APOE is the strongest genetic risk factor for late-onset #Alzheimers. @ia_windham et al @cohenlaboratory find that APOE can traffic to the surface of #LipidDroplets in astrocytes. APOE4 on LDs causes defects in LD composition & morphology hubs.la/Q02kwtks0
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