
IBD @uncgastro| Former GI at Colorado, @EmoryIMChiefs & @EmoryMedicine| #IBD & #Outcomes| Opinions my own. RT≠endorsement.
Chapel Hill, North Carolina
Joined October 2019
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🚨AGA New Guideline Alert🚨
🔗gastrojournal.org/article/S0…
▶️AGA Living Guideline: Pharmacological Management of Moderate-Severe Ulcerative Colitis
I’ll break down its 14 recommendations down over the next 7 tweets 🧵 👇
#AGA #GI #UC #IBD #MedTwitter
1/9
John Haydek, MD MS retweeted
🌟 Our first-ever living guideline for managing moderate-to-severe #UlcerativeColitis led by @berkeleydoc, @manasiagrawalmd, @Jhaydek, @ashwinmdibd, @FrankIScottMD, @EdwardLoftus2 prioritizes early use of advanced therapies over a step-up approach.
ow.ly/t2Ru50UahEi
Link to our clinical guidance page:
gastro.org/clinical-guidance…
@AGA_Gastro , @AshwinMDIBD , @EdwardLoftus2 , @berkeleydoc , @ManasiAgrawalMD , @FrankIScottMD
@BenClickMD ,
@KatarinaGreer2 , @MLaszkowskaMD , @David_LeimanMD , @JenniferKMaratt , @BabuPMohan2
@tareksawas, @GauravsyalMD
@Jarshah4 , @margaretzhou , @SultanShazi
✳️11-12 . For TNF + IMM therapy, when should you stop?
❌ stop TNF if combo
🤷♂️Knowledge gap: no recommendation on continuing IMM or when to stop 🗓️
✳️13. For patients w/ mod-severe disease:
👍Early advanced therapy
❌No step-up 🪜therapy
✳️14 If now on advanced 💊, stop 5-ASAs
✳️8, ✳️9, ✳️10 Combo therapy 💊+💊
🔹 TNF + immunomodulator > TNF or IMM alone
🤷♂️Knowledge gap: no recommendation about whether IMM + non-TNF biologic is helpful
7/9
✳️5, ✳️6, ✳️7. Immunomodulators 💊
❌ Thiopurines for induction
👍 Okay to use thiopurines for maintenance
❌ Methotrexate for induction or maintenance
6/9
❗️Important Points❗️
❗️High🪣or med🪣 are recommended over lower🪣, but high🪣 is not necessarily > med 🪣
❗️Factor in pt attributes when making tx choices, not just focusing efficacy buckets:
👨🦳age
🤰pregnancy status
🤒comorbidities
👩🦽functional status
🔅patient preferences
What about comparative efficacy for bio-naïve & bio-exposed?
✳️3. Bionaïve💉💊
High🪣: IFX, VDZ, OZA, ETR, UPA, RISA, GUS
Med🪣: GOL, UST, TOFA, FIL, MIRI
Lower🪣: ADA
✳️4. Exposed💉💊
High🪣: TOFA, UPA, UST
Med🪣: FIL, MIRI, RISA, GOL
Low🪣: ADA, VDZ, OZA, ETR
4/9
✳️1 & ✳️2: What is efficacy of 💊 compared to placebo for all-comers?
High🪣: IFX, GOL, VDZ, TOFA, UPA, UST, OZA, ETR, RISA, GUS
Med 🪣: ADA, FIL, MIRI
Caveats 🔦
1.JAKis often 🙅♂️ for 1st line use per FDA
2.Biosimilar= originator
3.SC = IV
3/9
But first, details 🤓
📍Developed w/ GRADE framework
📍Thresholds for clinically meaningful benefits: >10% vs. pbo & >5% vs. other 💊
📍Provides guidance by stratifying of 💊 into 🪣s: high-, intermediate-, and lower-efficacy, for biologic-naïve and -exposed patients
2/9
John Haydek, MD MS retweeted
Some Monday ACG moments ✨🩵Happy to reunite with my big friend/mentor @VictorChedidMD 🩵 and so happy to meet again with @JHaydek and @L_Sahyoun and share experiences from our first months as IBD attendings! 😀grateful for those @MilestoneIBD friendships !!!
John Haydek, MD MS retweeted
.@JHaydek is at Poster P2674 to tell you why you should consider primary prophylaxis in patients with #PSC to prevent #pouchitis. Come learn more. #ACG2024 @UNCGastro @UNCGIFellowship @LauraRaffalsMD @PriSantiagoMD @shannonchangmd @JHashashMD @tqaziMD @HorstIBDDoc @MLongMD
John Haydek, MD MS retweeted
Ever wonder if you should biopsy normal neoTI after resection in CD?
▶️Normal (i0) endoscopy
▶️Active inflammation
⬆️POR risk
More evidence that active 🔬 disease can risk stratify IBD clinical risk. @RavShahMD @IBDBen @DrJordanAxelrad @EdBarnesMD
journals.lww.com/ajg/abstrac…
John Haydek, MD MS retweeted
I profoundly disagree with this.
Asking questions - particularly those that prompt the learner to think & not simply recall information - is a GREAT teaching method.
If you create a safe learning environment it isn’t “toxic quizzing” but the Socratic method at its best.
🎈PIMPING during teaching rounds😆
From
Things We Do for No Reason : Toxic quizzing in medical education shmpublications.onlinelibrar…
John Haydek, MD MS retweeted
What it’s like to be in healthcare right now:
“We will pay you $2 for that pie”
“But it costs me $4 in pie ingredients and $2 in human labor to make a pie. We need $6 to break even”
“Sorry, we’ll only pay you $2 for that pie. We suggest you make many more pies that you also sell for $2/pie. New requirement is 6 pies/day”
“But then we are still losing $4 per pie. How does making more pies help us?”
“We just found out flour is on shortage so you’ll have to buy more expensive imported flour and will lose $5 per pie. Or you can consider making pies without flour.”
“But I can’t make pies if we keep losing money on pies. And I can’t make pies without flour”
“We suggest you ditch rolling pins and remove any fruit filling as a cost saving measure. And consider limiting how much time you bake the pie for to use less oven time”
“But then how can I even make a pie that resembles a pie?”
“We appreciate the question and have no response. We empower YOU to solve this problem. We have scheduled 4 meetings to discuss how you can make more pies with less ingredients and less oven time and less labor”
“But it seems the root of the problem here is actually that we don’t get reimbursed fairly for our pies…”
“Don’t say that out loud. Please get back to making pies with no filling and no flour and no rolling pins and be sure to attend the meetings.”
#medtwitter #Pediatrics #insurance
John Haydek, MD MS retweeted
Dear Doctors,
Happy annual cut-your-compensation day.
This one comes with an additional demand for you to change your practice to address “whole body care” and spend lots of administrative overhead proving your “quality” with metrics that are mostly gamesmanship and complex paper pushing.
Love,
US Government
cms.gov/newsroom/press-relea…
TLDR: 2.8% cut across the board through the RVU conversion rate. This has decreased every year since 2020, for a 10% cut ever since become COVID "healthcare heroes"...🤬
#medtwitter @CMSGov @MedicareGov @AmerMedicalAssn @ACEPAdvocacy
John Haydek, MD MS retweeted
Just a simple reminder today that Medicare thinks physician work is 30% less valuable today than it was in 2001.
Despite asking us to see more patients, click more buttons and fill out more paperwork, we deserve to be reimbursed 30% less than we did 23 years ago.
If you're considering a career in healthcare, what would you do if the US government considers your expertise to be devaluing at that rate?
Medical students recognize this, which is why a recent survey found that over 60% don't plan on practicing clinical medicine. They want to pursue consulting or public health careers instead.
I don't blame them. If you held any asset that was depreciating at that rate, you'd invest that capital elsewhere.
We will never fix the physician fee schedule, though. Our only hope is to even the playing field. We must fight for site neutrality and allowing physician owned hospitals. We must reform 340B. We must fight certificate of need laws.
Lets put delivery of healthcare in the hands of physicians.
@DoctorJesseMD @sdixitmd @anish_koka @JPGK_MD @KatieOrrico
ama-assn.org/practice-manage…




















