@Jchmpg
Joined January 2015
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  • Following124
  • Followers11
We are hiring! Come and work with us from aberrant mRNA translation to innovative treatment opportunities. #agamilab #Bioinformatics #NKI nki.nl/careers-study/vacanci…
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It has been a long journey since we first uncovered defective translation in cancer upon amino acid shortage in 2019 and today where we have been finally able to target cancer cells by adoptive T cell therapy against those aberrant peptides.
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Hopefully more T cell Receptor will be identified and more clinical applications will follow. A big thanks to the all Agami Lab and to our collaborators and fundings that have been essential to achieve this work. @JOlweus @oncodeinstitute @NKI_nl
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Please have a look to our new publication in Immunity. cell.com/immunity/fulltext/S… (@ImmunityCP )!

Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA transl...

Interferon γ secretion by activated T cells alters the immunopeptidome landscape of cancer cells, enriching for W>F substitutant epitopes. Champagne et al. demonstrate that these induced neoepitopes...

cell.com
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We are thrilled to enounce the selection of our principle investigator Reuven Agami as a new member of @_knaw for his "series of highly original and high-impact discoveries"! lnkd.in/d9PxWRnq
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We are excited to share our recent review published fresh in Molecular Cell. It highlights recent advance on various protein diversification events by mRNA translation in cancer. #cancer #molecularcell #AcademicTwitter #mRNAtranslation #Cell cell.com/molecular-cell/full…

Proteome diversification by mRNA translation in cancer

In this issue of Molecular Cell, Kochavi et al. review recent findings describing how diverse mRNA translation mechanisms elicit cancer-specific protein diversification. Particular attention is paid...

cell.com
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Please get in touch if you are interested in PhD or postdoc position in bioinformatics ( at the intersection of cancer , immunology and proteomics ) #AcademicTwitter #Bioinformatics
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We are looking for a talented Postdoc fellow to investigate "sloppiness" in mRNA translation in cancer. More details are below. #academicjobs #postdoc #CancerResearch #sciencejobs
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We wrote a review that provides a detailed account of the antigen landscape of cancer cells. Hope you enjoy reading it :) aacrjournals.org/cancerres/a…
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Happy to share our last review recently published in TIG. Here, we discuss PRF as well as "slopiness" and its consequences in cancer cells upon stress that we have recently uncovered. Thanks to @AgamiLab for giving me this opportunity to write a review! authors.elsevier.com/a/1f9Cw…
A nice overview of our work released by the Dutch newspaper NRC! Trek in tryptofaan nekt kanker nrc.nl/nieuws/2022/03/10/tre…

Ontdekking kan leiden tot nieuwe immuuntherapie tegen kanker

Geneeskunde: Amsterdamse onderzoekers hebben een manier gevonden om de afweer te leren kankercellen te herkennen en aan te vallen.

nrc.nl
Really happy to share our latest work where we uncover that cancer cells experiencing tryptophan shortage wrongly incorporate phenylalanine at tryptophan codons. This generates aberrant proteins that can trigger immune response. @AgamiLab @abhipataskar42 nature.com/articles/s41586-0…

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Nature - Tryptophan depletion, which occurs in tumours, results in in-frame translation across tryptophan-encoding codons by phenylalanine substitution.

nature.com
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Online Now: Oncogene-dependent sloppiness in mRNA translation dlvr.it/S8QmC0

Oncogene-dependent sloppiness in mRNA translation

When amino acids are scarce, cancer cells are prone to produce aberrant protein. Here, Champagne et al. show that these errors result from the hyperactivation of oncogenic pathways. This cancer...

cell.com
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