Husband, Dad, Professor/Director. Chemical Biology, Drug Discovery, TPD, PROTACs, Molecular Glues, ADCs, Proteomics, & AI/ML. We do 💻🧪🧬 🐁 Views are my own.
Houston, TX
Joined February 2011
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Jin Wang 王津 retweeted
#AI-based structural modeling can guide chemists early for compound optimization, well before experiments reveal how a compound works. @JinWangLab, H Lin et al @bcmhouston @BCMCancerCenter @SandboxAQ @NatureComms #BCMPostdoc #MolecularGlues #Therapy bcm.edu/news/ai-structure-pr…
Jin Wang 王津 retweeted
A team of scientists at Baylor College of Medicine @bcmhouston and the tech company @SandboxAQ has developed a method for discovering #molecularGlues. @JinWangLab, H Lin et al @BCMCancerCenter @NatureComms #BCMPostdoc #Therapy cen.acs.org/pharmaceuticals/… @genengnews
When the sucking kicker missed the FG, I knew it would the same script!! Why can’t #OSU get a legitimate kicker!!!
Jin Wang 王津 retweeted
The @JinWangLab, H Lin et al developed a new analytical tool to optimize the potency and selectivity of drugs. #drugDesign @NatureComms @GENbio genengnews.com/topics/drug-d…
Congratulations to Xiangyu Deng and Yang Gao at @RiceUniversity for their outstanding work unraveling the complexities of RNA editing! Biochemical profiling and structural basis of ADAR1-mediated RNA editing: Molecular Cell cell.com/molecular-cell/full…
Interestingly, using the biochemical assays developed in this publication, we tested ZYS-1 (which I noted last week is not a genuine ADAR1 inhibitor) and confirmed it fails to inhibit ADAR1 even at concentrations as high as 1 mM.
Excited to share our new preprint on @biorxivpreprint , where we challenge the claim that ZYS-1 is a potent ADAR1 inhibitor, as reported by Wang et al. in @NatureCancer. Re: Concerns Regarding the Validation of ZYS-1 as a Bona Fide ADAR1 Inhibitor biorxiv.org/content/10.1101/…
Our results revealed that ZYS-1 does not inhibit ADAR1 activity at concentrations up to 1 mM, challenging previous conclusions based solely on binding data.
This underscores the need for target-specific assay validation in drug discovery. Join the conversation and read our full preprint for a detailed discussion. #ADAR1 #DrugDiscovery #RNAEditing #CancerResearch #AssayValidation
Jin Wang 王津 retweeted
The NIH funds 4,400 active projects totaling $2.5 billion in Texas, much of it in Houston.
These cuts violate the law, hurt people, and undermine the very system of scientific research & groundbreaking advancements that we are so proud happen in #TX07.
houstonchronicle.com/politic…
Jin Wang 王津 retweeted
Today, we at OpenAI launched Deep Researcher and I wanted to share a deeply personal story about how amazing this tool is and how it will change the world. Trigger warning, related to cancer....1/9
Jin Wang 王津 retweeted
Excited to share that the AlphaFold 3 model code and weights are now available for academic use.
Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmind/a… 1/2
