@KSamalaMD

🩺🧬Internal Medicine-Medical Oncology. @pghoncology 🇵🇭 🫁Thoracic Oncology Fellowship at Cross Cancer Institute. @crosscancer50 🇨🇦 @PSO1964 Vice-President, 2025

 Edmonton, Alberta
fb.com/dockennsamala
Joined February 2022
  • Tweets541
  • Following166
  • Followers131
321Media
Excellent talk on ctDNA analysis of the #CROWN trial by Dr @bensolomon1 . Definitely a lot of things to learn esp on the early progressors and how to improve their outcomes. #ESMO26
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Temab-A : a novel anti c-met protein ADC #ESMO26
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Median PFS was 6.8 mos and median OS was 13.8 in the overall EGFRwt cohort #ESMO26
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ctDNA analysis of the CROWN trial by @bensolomon1 #ESMO26 ✅️ early progressors : higher no. Of mutations, including TP53 ✅️ inflammatory response was the predominant EP-associated pathway
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Lorlatinib effective regardless of ALK variant #ESMO26
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✅️ ctDNA noted new ALK resistance mutations ✅️ higher mutations and higher inflammatory response -> may help identify early progressors (question is, what can we do for them, tx escalation?) #ESMO26
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Interesting integration of ctdna directed therapy in NSCLC ✅️ baseline non-detectable ctDNA -> good prognosis, might be an option for Osimertinib mono ✅️ if without ctDNA clearance after 3-4 weeks -> better median PFS if chemo is addred to osi mono #ESMO26
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#FLAURA2 analysis of CTDNA analysis @dplanchard #ESMO26 • baseline detected plasma EGFRm correlated with shorter PFS
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• plasma EGFR clearance was prognostic but not predictive • combi tx > osi mono regardless of plasma EGFR clearance status #ESMO26
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#PACELung trial CTDNA guided tx intensification is feasible; results comparable to historical data #ESMO26
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Kenn Samala retweeted
Aakash Desai@ADesaiMDOct 23
1/ My top 7 thoracic picks for #ESMO26 (Madrid, Oct 23–27), ranked. @myESMO 5 of these phase 3s already announced positive toplines. ESMO is where we finally see effect sizes. The question each one answers 🧵 #LCSM @LungCancerRx @OncoAlert @oncodaily
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Kenn Samala retweeted
gilberto lopes
@GlopesMdOct 21
Five lung cancer trials to watch at #ESMO26: DeLLphi-305 KRAScendo 1 SAFFRON OptiTROP-Lung04 OptiTROP-Lung06 Encouraging signals. Full data matter: survival, CNS activity, toxicity and quality of life. Figure separates published evidence from sponsor toplines. #LCSM
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Never miss an opportunity for a selfie when you bump into your Thoracic Oncology Idols - Dr Natasha Lieghl and Dr James Chih-Hsin Yang 😊🫁 #ESMO26
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Excellent talk on liquid biopsies by Dr Natasha Leighl. Also, priviliged to work with her for the ESMO PAGA on Early Lung Cancer 🫁 So nice to see you, Natasha and hopefully more collaborations in the future! 😊 #ESMO26
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Liquid biopsies in advanced lung cancer: The Future has arrived by Dr Natasha Leighl of @pmcancercentre #ESMO26
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The future: #ESMO26
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Key Takeaways of liquid biopsies • use as a "screening" test - pre diagnostic pladma ctDNA • screening test for molecular diagnosis in targeted therapy resistance #ESMO26
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Interesting how liquid biopsy in detecting SCLC transformation #ESMO26
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Use of ctRNA for profiling NSCLC #ESMO26
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Use of Pre-diagnostic plasma NGS can dec time to treatment by ~50% #ESMO26
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