ChemOrigins: A community curated database for origins of life chemistry １．ChemOrigins is a new open-access, community-curated knowledge graph focused on prebiotic chemistry. It organizes over 300 experimentally supported chemical reactions linked to the origin of life, enabling detailed, structured exploration of how life's building blocks could have emerged. ２．Unlike generative or predictive models, ChemOrigins focuses on experimental evidence. Each entry links chemical reactions with conditions, agents, and sources via a graph database, emphasizing scientific rigor and traceability. ３．The database uses a graph-based structure where molecules, reactions, catalysts, and literature references are interconnected. This design mirrors the complexity of real-world chemistry and allows efficient traversal of reaction networks. ４．To lower the technical barrier, ChemOrigins provides a user-friendly annotation app. Contributors can upload curated reactions without knowing version control systems, simplifying participation in community-driven data curation. ５．Querying capabilities include text search, network expansions from seed molecules, and curated modules. These features allow users to identify plausible reaction pathways and explore chemical space with just a few clicks. ６．Modules are especially powerful: they group reactions into meaningful clusters such as biosynthetic routes to amino acids or nucleotides. For example, alanine can be synthesized via pyruvate, Strecker synthesis, or serine reduction—each mapped in a separate module. ７．ChemOrigins facilitates hypothesis generation. One module starts from CO₂ and traces a multi-step path to methanol, highlighting how cross-environmental chemistry might have powered early carbon fixation—even if not experimentally confirmed as a one-pot process yet. ８．The platform complements existing resources like KEGG or PubChem but is specifically tailored to prebiotic contexts. It’s interoperable, machine-readable, and can be used for education, data mining, and model validation. ９．While LLMs promise automatic knowledge extraction, ChemOrigins argues for curated, human-verified datasets. In a field rife with uncertainty and competing theories, such scholarly curation is essential for quality and consensus. １０．ChemOrigins is not just a database—it’s an infrastructure to organize prebiotic chemistry knowledge, invite community participation, and support the growing field of origins-of-life research with accessible, credible, and structured data. 💻Code: github.com/brunocuevas/chemo… 📜Paper: biorxiv.org/content/10.1101/… #OriginsOfLife　#PrebioticChemistry　#KnowledgeGraph　#OpenScience　#ChemicalBiology　#SystemsChemistry　#GraphDatabase　#Chemoinformatics