@KarenGlassLab

Associate Professor of Pharmacology, University of Vermont College of Medicine We study how the histone code is read and what the words mean. #epigenetics

 Burlington, VT
med.uvm.edu/biochemistry/lab---glass
Joined September 2017
  • Tweets1.5K
  • Following966
  • Followers707
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Karen C. Glass, PhD retweeted
Korostelev Lab@KorostelevLabOct 25
We find that 5MP proteins promote high-fidelity initiation by binding 48S scanning complex to bypass weak start codons. We propose renaming them eIF1S (euk initiation factor 1 scanning). Great collab w/ @grigoriefflab.bsky.social Congrats to all authors! science.org/doi/10.1126/scia…
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Karen C. Glass, PhD retweeted
Science Magazine
@ScienceMagazineOct 15
In Science, researchers present RFdiffusion3, a new generative AI system that designs proteins and nucleic acids atom by atom, which could enable the ability to engineer novel biomolecules with precise, complex functions. Learn more: scim.ag/4hOQVIF
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Karen C. Glass, PhD retweeted
US Crystal Comp@USCrystalCompOct 12
💎📦 The @USCrystalComp crew is at it again! This time at @UCFChemistry , where Fernando @fjuriberomo and grad student Abdullah have been busy packing alum for our #2026USCGC crystal growers! 🧪 It takes a village to grow a crystal… and apparently a LOT of packing tape! 😂
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Karen C. Glass, PhD retweeted
Ivan
@chaperones4lifeSep 30
Nucleosome Core Allostery Governs Chromatin Recognition and Cell Fate biorxiv.org/content/10.64898…

Nucleosome Core Allostery Governs Chromatin Recognition and Cell Fate

Nucleosomes regulate chromatin folding, accessibility, and factor recruitment. Current models primarily attribute these functions to histone tail modifications, while the core is largely viewed as a...

biorxiv.org
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“When you start looking at the brain at high resolution, you see that it’s almost galactic in its complexity. And somehow it all works together to achieve a unified function.” — Davi Bock, Ph.D. Watch the full video: bit.ly/4iRVpiD #UVM #UVMLarnerMed
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Karen C. Glass, PhD retweeted
Ivan
@chaperones4lifeSep 21
Structural principles underlying the evolution of SWI/SNF chromatin remodelers science.org/doi/10.1126/scia…

Structural principles underlying the evolution of SWI/SNF chromatin remodelers

Adenosine 5′-triphosphate–dependent switch/sucrose nonfermentable (SWI/SNF)–family chromatin remodelers regulate genome accessibility by repositioning nucleosomes, yet how these complexes diversified...

science.org
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The blueprint for life, neatly folded asbmb.org/asbmb-today/scienc…

The blueprint for life, neatly folded

Bit by bit, biologists are deciphering the complex 3-D — and 4-D — architecture of the genome and learning how all the squeezed-together stuff of DNA keeps itself in order. What they find could lead...

asbmb.org
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Every single year...lol
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I was honored to present our work in the "Protein-nucleic acid interactions in essential cellular functions" session today at #IUCr2026. It was fun to share our story about how learning cryo-electron microscopy has enabled us to gain new insights into the function of human ATAD2B
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All of the talks were outstanding with an exciting speaker list that included Drs. Yang Gao, Jean-Paul Armache, Charles Bou-Nader, Chacko Jobichen, and Albert Weixlbaumer. Many thanks to the organizers and session chairs Drs. Markus Wahl and Cynthia Wolberger for the invitation!
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I'm out in Calgary for the @IUCr2026, and visited with my friends and collaborators at the University of Lethbridge. Thanks to Dr. Demeler and Dr. Patel for hosting me! Their new science building is impressive and comes with a cool periodic table of elements.
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Another fun place in the new Science Commons building is the Agility Innovation Zone, a 'maker space' where everyone can access tools put their ideas into action.
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But what I loved most about this building is that they have a full-time and dedicated space for community STEM education. Destination Exploration hosts and educates K-12 students right on the college campus! Year round! ulethbridge.ca/destination-e…. @uLethbridge
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Karen C. Glass, PhD retweeted
David R. Liu
@davidrliuJul 22
Today in @Nature we report how AI-guided redesign enhances protein evolution. Integrating ProteinMPNN sequence design with autonomous laboratory evolution, we establish a workflow to engineer enzymes with improved properties over those evolved from natural proteins. Redesigned starting points consistently evolve an expanded fitness landscape, reaching new function with higher activity, specificity, and stability than their natural counterparts. drive.google.com/file/d/1C-Q… 1/14
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Karen C. Glass, PhD retweeted
Edward T Eng@edward_engJul 20
The next #CryoEM Current Practices Webinar speaker will be @Jen_Cash_11 from UCSD speaking on "Cryo-EM single-particle analysis of small and dynamic proteins" 7/30/2026 at 12 PM ET / 9AM PT Registration is at no-cost, but sign-up is required: us02web.zoom.us/webinar/regi…
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Vermont summers are short but sweet! The Glass Lab is making the most of it by soaking up some sunshine at The Spot on the Dock. Also, someone may have sketched cryo-EM plans on a napkin. Stay tuned. ☀️🌊 #GlassLab #UVM #VermontSummer #LabLife
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Karen C. Glass, PhD retweeted
Michael King@profmikekingJun 24
Do I still wear a bow tie? Yes… …periodically. #dadjokesfordadweek
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Karen C. Glass, PhD retweeted
Steve L. Bonilla@Steve_BonillaJun 18
Honored to have the support of @pewtrusts —thrilled to join such an amazing group of scientists.
Rockefeller University@RockefellerUnivJun 16
Rockefeller's @Steve_Bonilla has been named a 2026 scholar by @pewtrusts! Steve is recognized for his work investigating how RNA molecules fold into three-dimensional structures to drive complex biological processes. Congratulations!
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Karen C. Glass, PhD retweeted
biohub
@biohubJun 12
The laser phase plate is leveling up cryoEM so we can see biology like never before. Learn more: bit.ly/4vIPC1U
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