Telomere metabolism, innate immune signaling, cancer initiation, and proliferative boundaries -- relocated to Blue Sky Dec 2024: @karlsederlab.bsky.social
San Diego, CA
Joined July 2016
- Tweets71
- Following174
- Followers647
- Likes111
The Karlseder Lab retweeted
Introducing Telo-seq: a new tool from @SalkInstitute and Oxford @Nanopore that will revolutionize the study of aging and cancer. Scientists can now measure and sequence telomeres on individual chromosomes with unprecedented resolution. #SalkHealthyAging
salk.edu/news-release/unveil…
The Karlseder Lab retweeted
Learn how @KarlsederLab & team used nanopore technology to investigate telomere shortening during cellular aging.
Check out how they also studied how alternative lengthening of telomeres and telomerase impact iPSCs and cancer cells.
Read more: bit.ly/46AgRPb
The Karlseder Lab retweeted
Our latest review 'Telomeres as hotspots for innate immunity and inflammation' is now live @repair_dna! Here, we describe how dysfunctional telomeres activate innate immune pathways and fuel inflammaging. Check it out @Sprzetocka @KarlsederLab
doi.org/10.1016/j.dnarep.202…
The Karlseder Lab retweeted
Our lab website is now live! Explore opportunities and learn about our research on telomere-mitochondria-innate immunity crosstalk at nassourlab.com
The Karlseder Lab retweeted
Postdoc positions are available in our group at the University of Colorado @cuanschutz to study the crosstalk between telomeres and mitochondria in innate immunity. See details below, and feel free to DM or email me for further info!
The Karlseder Lab retweeted
Some tumors repair their DNA via microhomology-mediated end joining (MMEJ), rather than with homologous recombination (HR). Scientists find that MMEJ relies on the APE2 nuclease, revealing a chink in the armor of HR-deficient cancers. @ArnoultLab
ow.ly/jv8y50NHfLT
The Karlseder Lab retweeted
Excited to share this spotlight on @MolecularCell with @LiuhYow, highlighting a telomere-dependent tumor suppressive mechanism via mitochondria that acts during replicative crisis from @NassourJoe @KarlsederLab
authors.elsevier.com/c/1gtA7…
The Karlseder Lab retweeted
JOB OPPORTUNITY! 🧠🔬🧪
9 labs at Salk have joined forces to understand how aging contributes to Alzheimer’s + other age-associated conditions. The team is seeking talented postdoctoral fellows who can work across disciplines.
Please RT and share!
recruiting2.ultipro.com/SAL1…
The Karlseder Lab retweeted
#NRMCBResearchHighlight:
👉🏽From shortening telomeres to replicative crisis
highlighting work by @NassourJoe, @KarlsederLab and colleagues, recently published @Nature
go.nature.com/3Ezr8Qq
The Karlseder Lab retweeted
"My project aims to uncover pathways that impede replication stress-induced telomere fragility, ensure faithful duplication of the genome, and prevent oncogenic transformation."-Sara Przetocka postdoctoral fellow, @KarlsederLab
@SPrzetocka
#IDWGIS2023 #February11 #WomenInScience
The Karlseder Lab retweeted
The @KarlsederLab, Salk Prof. Gerald Shadel & @NassourJoe uncovered how telomeres and mitochondria communicate to promote inflammation. The @Nature discovery may lead to new ways of treating #cancer and other harmful consequences of #aging.
salk.edu/news-release/telome…
ALT In this illustration, shortened telomeres are represented as the ends of the two sparklers. The telomeres sendoff inflammatory communication signals, represented as sparkler paths, to mitochondria. The telomere-to-mitochondria communication activates the immune system which destroys cells that might become cancerous. Credit: Salk Institute
The Karlseder Lab retweeted
Our latest results have been published! onl.bz/H2h55Cx In this study, we aimed to explore the function of the RecQ helicase member WRN in mitotic telomere deprotection. Telomere is a protective DNA-protein structure at the end of our chromosomes. (1/4)
The Karlseder Lab retweeted
Please RT! Help us find some amazing post-docs, techs, and students to join the Towers Lab! Together we can build a culture of teamwork and inclusivity, centered around a passionate curiosity for pushing the limits of cancer cell biology. @BlackinCancer @WAutophagy @mitowomen
The Karlseder Lab retweeted
Coming Soon - The 4th Annual La Jola Aging Meeting, March 25th 2021. A great lineup of speakers, including Keynote by Darren Baker, Mayo Clinic. Registration required.
salk.edu/events/science-even…
The Karlseder Lab retweeted
Some new work from the lab is out today in @NatureComms. Here we investigate mechanisms of cell lethality induced by replication stress and identify how replication stress induces mitotic death in the same cell cycle.
(1) Our paper "Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection" is out today @NatureComms. Here we identify how lethal replication stress induces mitotic death in the same cell cycle. nature.com/articles/s41467-0…
The Karlseder Lab retweeted
Just heard Joe Nassour from our neighbor lab, the @KarlsederLab talk about this beautiful piece at #MechModels2019
The Karlseder lab studying the relationship of telomeres to cancer discovered that the cellular recycling process called autophagy—generally thought of as a survival mechanism—actually promotes the death of cells, thereby preventing cancer initiation. bit.ly/2RL0nCd
The Karlseder Lab retweeted
It’s the @KarlsederLab (current and past) hour here at #ACCM2019 - beautiful work by Joe Nassour on autophagy followed by a nice story from @makotothayashi2 (now at @KyotoU_News) detailing sister chromatid fusion in destabilised cell cycles.
The Karlseder Lab retweeted
Dinner and drinks with Joe Nassour (@KarlsederLab), @makotothayashi2, @AgnelSfeir, Hilda Pickett & @tonycesare4. #ACCM2019
The Karlseder Lab retweeted
Mini @KarlsederLab lab reunion in Sydney at #accm2019 with Joe Nassour, @makotothayashi2 and @tonycesare4.
