We use network biology, multi-omics & organoids to study autophagy & host-microbe interactions for developing Precision Medicine solutions in IBD @ImperialMDR
London, England
Joined February 2018
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🚨 New paper alert 💥 We show @IBDJournals how #IBD-associated 🧬 SNPs can switch 🔄 upstream signals, leading to patient-specific susceptibilities ⚡
✅ Helping to explain patient heterogeneity
✅ Linking genetics w/ environmental & microbial signals
👉 academic.oup.com/ibdjournal/…
KorcsmarosLab retweeted
8/ In summary, we have found that non-response reflects an inflammatory cytokine network that anti-TNF therapy leaves intact. The distinguishing feature is network wiring, not any single cytokine. Work done with @KorcsmarosLab @ImperialMDR. Preprint: biorxiv.org/content/10.64898…
KorcsmarosLab retweeted
1/ Anti-TNF agents are first-line therapy in Crohn's disease, yet many patients do not achieve remission, and the basis for non-response remains poorly understood. Our new study proposes that the cause is not a single cytokine, but the wiring of the cytokine network.
KorcsmarosLab retweeted
1/ Our new review in DNA and Cell Biology. Blocking one cytokine at a time rarely gives durable remission in UC. Here we make the case for treating cytokines as networks, rewired between UC phenotypes, and worth mapping in space and over time.
doi.org/10.1177/104454982614…
Very happy to have this new paper out on #Salmonella / bacterial transcription factor activity analysis. A great extension to our SalmoNet2 database, and the final paper from our projects done btw 2014-2021 in the Earlham & Quadram Institutes.
Well done @martonolbei!
Excited to share our latest extension to the SalmoNet2 database. SalmonAct is a new prior knowledge resource for inferring transcription factor activity in Salmonella. If you work on Salmonella (or bacterial transcriptomics more broadly), give it a look!
journals.asm.org/doi/10.1128…
KorcsmarosLab retweeted
imperial.ac.uk/news/articles…
Summary of our recent publication on cytokine networks in ulcerative colitis
KorcsmarosLab retweeted
A study identifies the regulatory cytokine TL1A as an upstream regulator of the inflammatory cytokines TNF and IL-23A in ulcerative colitis and uncovers other previously unknown cytokine-cytokine interactions in the disorder. @martonolbei @TheQuadram scim.ag/46AGOkq
This is very special, not everyday you can see your paper highlighted by Science :)
Through systems immunology analysis, a team has identified potential therapeutic targets for the treatment of #UlcerativeColitis, an inflammatory bowel disease characterized by dysregulated cytokine signaling in the GI tract. @SciSignal scim.ag/4kmEVNZ
KorcsmarosLab retweeted
This week’s new issue of #ScienceSignaling has arrived!
A study reveals how fetal cells could activate maternal natural killer cells during early pregnancy, systems immunology reveals cytokine targets in ulcerative colitis, and more. scim.ag/4ko4K0k
KorcsmarosLab retweeted
To validate our predictions, we used patient-derived colonic organoids and organoid-ILC cocultures to test whether predicted cytokine-cytokine interactions actually occur in a physiologically relevant system.
KorcsmarosLab retweeted
We used systems immunology to analyse single-cell RNA-seq data from colonic biopsies of treatment-naive patients, treatment-exposed patients, and healthy donors, building cytokine interaction networks across disease states.
KorcsmarosLab retweeted
Why do many UC patients struggle despite cutting-edge biologics? We suspected the answer lies not in individual cytokines, but in how they communicate as an interconnected network during disease and treatment. New @KorcsmarosLab paper in @SciSignaling science.org/doi/10.1126/scis…
KorcsmarosLab retweeted
Decoding cellular conversations in ulcerative colitis reveals new drug targets
New research from MDR's @KorcsmarosLab reveals previously hidden mechanisms driving inflammation and identifies new therapeutic targets ⬇️
imperial.ac.uk/news/articles…
KorcsmarosLab retweeted
A new era for gut science begins at Imperial
Dr Tamas Korcsmaros and Dr Lejla Gul, Research Fellow introduce the Centre for Intestinal Systems (CIS), a hub dedicated to advancing human-relevant gut research ⬇️
blogs.imperial.ac.uk/imperia…
KorcsmarosLab retweeted
MDR’s Dr Tamas @KorcsmarosLab welcomed @BBCTech Now to the Gut-on-Chip Centre to see how we can grow a living mini-gut in the lab – creating a powerful tool for revealing why diseases and treatments impact patients in different ways.
Watch from 14min ⬇️
bbc.co.uk/programmes/m002mh8…
First time on BBC! Not just me but our new gut-on-chip and microbiome laboratories - the Centre for Intestinal Systems.
Modelling #IBD with #organoids and the #microbiome, & co-culturing them using various gut-on-chip systems just got aired on BBC News.
See below,starting at 14m
Our Gut-on-Chip Centre is working with cutting-edge technology to understand the complex ways that the gut impacts our health 🏥
We welcomed @BBCTech Tech Now to see how researchers are using these chips to advance biomedical research.
📺 Watch ⬇️
bbc.co.uk/programmes/m002mh8…
Our findings show how genetic variation reshapes cellular signaling in #IBD (see two patient-specific networks 👇), providing a foundation for #PersonalizedMedicine.
Collaborative work with @ibdleuven @bverstockt @NickPowellLab @modoslab @johanne_brooks 🙌
From @ImperialMDR
We were honored to get an Editorial at the journal highlighting our study and its implications. We are grateful for the great Claudio Fiocchi and Dimitrios Iliopoulos for their insightful summary.
academic.oup.com/ibdjournal/…
