@LabChao
 Beijing, China
lichaolab.com
Joined November 2018
  • Tweets59
  • Following299
  • Followers731
6Media
Chao Li Lab retweeted
Baran Lab
@BaranLabReadsJun 4
Final version of this work has appeared today in @ScienceMagazine : science.org/doi/epdf/10.1126…

Stereoretentive radical-based alkyl-alkyl cross-coupling

The construction of stereogenic C(sp3)–C(sp3) bonds through cross-coupling remains a formidable challenge owing to competing β-hydride elimination and homocoupling as well as the poor inherent...

science.org
Baran Lab
@BaranLabReadsJan 22

Stereoretentive Radical-Radical Cross-Coupling

Article · @BaranLabReads
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Cobalt-Catalyzed Photoelectrochemical Dehydration of Primary Alcohols | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

Cobalt-Catalyzed Photoelectrochemical Dehydration of Primary Alcohols

Abstract. The direct and selective dehydration of primary alcohols remains a longstanding challenge due to the instability of primary carbocations and the

pubs.acs.org
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Radical Retrosynthesis of Natural Products Enabled by Iron-based Reductive Olefin Coupling. Published today in @ChemRxiv : chemrxiv.org/engage/chemrxiv…
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Establishing the Comprehensive Structure-Activity Relationship of the Natural Antibiotic Kibdelomycin/Amycolamicin (Chao Li and co-workers) @LabChao onlinelibrary.wiley.com/doi/…

Establishing the Comprehensive Structure−Activity Relationship of the Natural Antibiotic Kibdelom...

Through extensive chemical synthesis, the first comprehensive structure–activity relationship (SAR) analysis of the potent natural antibiotics kibdelomycin (KBD) and amycolamicin (AMM) was establis...

onlinelibrary.wiley.com
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The final version of this study was published today in @Nature : nature.com/articles/s41586-0…
Baran Lab
@BaranLabReads19 Jan 2023
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
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Excited to share our latest paper on the total synthesis of Illicium sesquiterpenes. Not only access more targets but synthetically connect distinct molecular architectures of different subfamilies through late-stage skeletal reorganization triggered by Lewis acids or oxidants.
J. Am. Chem. Soc.@J_A_C_S11 Aug 2023
Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization | Journal of the American Chemical Society @CHNSci @TotalSynthesis @TotalSyntheses #Divergent #TotalSynthesis #sesquiterpenes #Rearrangement #LateStage pubs.acs.org/doi/10.1021/jac…

Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization

Abstract. We disclose unified, protecting-group-free, bioinspired divergent total syntheses of eight allo-cedrane and seco-prezizaane Illicium sesquiterpen

pubs.acs.org
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Nickel-Catalyzed C-I-Selective C(sp2)-C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides (Chao Li and co-workers) @LabChao onlinelibrary.wiley.com/doi/…
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Chao Li Lab retweeted
Baran Lab
@BaranLabReads6 Apr 2023
Modern alchemy appearing today in @ScienceMagazine : science.org/doi/10.1126/scie… Commentary (thank you Prof. Ye!): science.org/doi/10.1126/scie…

Overcoming the limitations of Kolbe coupling with waveform-controlled electrosynthesis

Rapid alternating polarity greatly expands the functional compatibility of a venerable electrochemical carbon–carbon coupling.

science.org
Baran Lab
@BaranLabReads27 Oct 2022
Modern Alchemy with rAP. Appearing today in @ChemRxiv is a solution to the longstanding (>100 year) challenge of extending the scope of the original Kolbe reaction beyond simple hydrocarbons bearing no functional groups: bit.ly/3sBQ5Ve
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Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
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Chao Li Lab retweeted
Mingji Dai@MingjiDai24 Oct 2022
Please check out our total synthesis of (−)-Peyssonnoside A @J_A_C_S. Big congratulations to Bo @BoXu44807071 and Chang! Catalysis-Enabled 13-Step Total Synthesis of (−)-Peyssonnoside A pubs.acs.org/doi/10.1021/jac…

Catalysis-Enabled 13-Step Total Synthesis of (−)-Peyssonnoside A

Abstract. We report a 13-step enantioselective and stereoselective total synthesis of (−)-peyssonnoside A, a unique diterpene glucoside with a rare and hig

pubs.acs.org
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Congratulations to chemist Prof. Phil Baran, who has been awarded the 2022 Danisco Foundation Science Excellence Award from @IFF. Baran is recognized for advancing science and technology relevant to the future of food, nutrition, and health magazine.scripps.edu/awards-… @BaranLabReads
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Final version of this study was published today in @J_A_C_S : bit.ly/3QGPDhP
Baran Lab
@BaranLabReads27 May 2022
Simple, practical, and broadly applicable. Next generation decarboxylative arylation, appearing today in @ChemRxiv : bit.ly/3z6Ko5Y
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🎁Do you recognize this PhD student in front of his hood in 1999? There he started out to become a true artist in @TotalSynthesis. Birthday present: autobio of S. Kent l-i-c.org/1129, the artist of Total Synthesis of #Peptides/#Proteins & #NativeChemicalLigation. Cheers!
Spring 1999 when Phil Baran was still 21 in front of his hood at Scripps Institute during his PhD time · photo by Eva E. Wille

ALT Spring 1999 when Phil Baran was still 21 in front of his hood at Scripps Institute during his PhD time · photo by Eva E. Wille

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Chao Li Lab retweeted
Baran Lab
@BaranLabReads1 Jun 2022
An atroposelective synthesis of Darobactin, appearing today in @ChemRxiv : bit.ly/3z9tJyC
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Chao Li Lab retweeted
Baran Lab
@BaranLabReads7 Feb 2022
Electroaffinity labeling: a powerful new tool for target identification and Chemical Biology. Appearing today in @ChemRxiv, a collaboration with brilliant @Merck scientists: bit.ly/3B5eSEv
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Chao Li Lab retweeted
Waser Group@LcsoLab4 Feb 2022
#LCSOSynthesisProblem of the week! Elija challenged us with the synthesis of Amycolamicin and Kibdelomycin from @LabChao in @J_A_C_S ! #Totalsynthesis Take a look: epfl.ch/labs/lcso/wp-content… For original paper: pubs.acs.org/doi/pdf/10.1021…
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#TotalSynthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin by Shaoqiang Yang, Chenglong Chen, Jie Chen, and Chao Li @LabChao in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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Chemoselective and Diastereoselective Synthesis of C-Aryl Nucleoside Analogues by Nickel-Catalyzed #CrossCoupling of Furanosyl Acetates with Aryl Iodides (Li) @LabChao onlinelibrary.wiley.com/doi/…
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Chao Li Lab retweeted
Qin Lab@QinLab29 Sep 2021
The final version of this study (collaboration with @rohanmerchant1 #MerckChemistry) has appeared in @NatureChemistry nature.com/articles/s41557-0… Thanks to Dr. Brocklehurst and @EdAndersonGroup for the highlights nature.com/articles/s41557-0…
Qin Lab@QinLab8 Feb 2021
We are excited to share our latest collaboration with @Merckchemistry @rohanmerchant1 to develop a new (non strain-release) approach to access bicyclo[1.1.1]pentanes (BCPs) with C1, C2 and/or C3 substitutions. chemrxiv.org/articles/prepri…
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Chao Li Lab retweeted
Malins Lab@Malins_Lab22 Jul 2021
Congrats to PhD student Yutong Lin @ANUChemistry for her fantastic work on electrochemical peptide modifications out today in @J_A_C_S! Awesome work, Yutong! pubs.acs.org/doi/10.1021/jac…

An Electrochemical Approach to Designer Peptide α‑Amides Inspired by α‑Amidating Monooxygenase...

Abstract. Designer C-terminal peptide amides are accessed in an efficient and epimerization-free approach by pairing an electrochemical oxidative decarboxy

pubs.acs.org
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