@LabLuthi

Neuroscience lab investigating sleep physiology 🔎🧠🌜 @UNIL🇨🇭 Now on https://xitter.cf/t.co/wvcBnb6sKt

wwwfbm.unil.ch/dnf/group/gaining-insight-into-the-roles-of-sleep-for-neuronal-function
Joined January 2020
  • Tweets363
  • Following362
  • Followers848
43Media
SleepLüthiLab retweeted
Inna Slutsky@inna_slutskyApr 12
Given these uncertain times, it’s time to reconnect and come together to discuss all things synapse at grc.org/synaptic-transmissio…. Join us in Italy for an outstanding lineup of speakers! We still have open slots for short talks and late-breaking findings. @of_sagol @SamYoungLab
3
7
785
SleepLüthiLab retweeted
Anita Luthi@anita_luthiFeb 1
👉New Preprint out on brain-wide spatiotemporal signatures of #locuscoeruleus activity fluctuations, combining fiber photometry and fMRI 👈A Conserved Locus Coeruleus fMRI Signature of Brain-State Transitions across Sleep, Anesthesia, and Wakefulness biorxiv.org/content/10.64898…
3
21
1,300
SleepLüthiLab retweeted
Anita Luthi@anita_luthi29 Dec 2025
Congrats Antoine, Paul-Antoine and all authors for this landmark study on #infraslow rhythms in reptile #sleep, out in @NatureNeuro today - comments here: thetransmitter.org/sleep/sno…

Snoozing dragons stir up ancient evidence of sleep’s dual nature

Lizard sleep may have more in common with mammalian sleep than was previously thought.

thetransmitter.org
1
3
223
🤩We’re calling for applications for the Physiological Reviews Editor-in-Chief position! 📅Application deadline: April 30, 2026 🎙️Candidate interviews: Spring 2026 🔗Apply now! ow.ly/OutZ50XKQ76
2
3
395
🧠 Paper alert! My scientific labour of love from my time at the @UKDRI at @ucl is now out in @NeuroCellPress ! Deep-layer 5/6 PV interneurons show early dysfunction in Alzheimer's models in vivo, tied to NPTX2 and GluA4 loss. 🔗 cell.com/neuron/fulltext/S08… 🧵Thread below ⬇️
3
18
91
5,990
SleepLüthiLab retweeted
SleepLüthiLab@LabLuthi8 May 2025
The @LabLuthi thanks #CIBM_ch organizers of the first #EEGResearch day - we enjoyed a very informative event and were glad to participate in a Duo Talk @unil #FBM #neuro
1
4
286
Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice: Current Biology cell.com/current-biology/ful…

Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across...

Using a mouse model of altered neurotransmission (Vamp2rlss), Guillaumin et al. show that differences typically observed between vigilance states in neural dynamics and spectral signatures can be...

cell.com
1
16
1
39
2,547
SleepLüthiLab retweeted
Anita Luthi@anita_luthi17 Mar 2025
👉👉New paper alert from @LabLuthi ! Newly promoted Dr. Cherrad, with @GFoustoukos, @FernandezLmj and others combines stimulation of sensory neurons from the #vagus nerve with #sleep, #heartrate, temperature and #locuscoeruleus recordings @unil #FBM #Neuro
bioRxiv Neuroscience@biorxiv_neursci16 Mar 2025
Vagal afferent activation induces a NREM-sleep-like state with brain-body cooling, but locus coeruleus activation biorxiv.org/content/10.1101/… #biorxiv_neursci

Vagal afferent activation induces a NREM-sleep-like state with brain-body cooling, but locus...

Parasympathetic nervous system activity, vital for restorative sleep, is influenced by vagal sensory afferents, but how these shape brain-body correlates of sleep remains open. We investigated this...

biorxiv.org
15
1
52
3,866
Brava Francesca! Presenting for the first time her results on LC photometry-fMRI at an international conference #EMIM2025 🎙️ Always a special moment. More to come soon!
2
20
1,113
SleepLüthiLab retweeted
Yuval Nir 💔@LabNir7 Mar 2025
The night’s watch: Exploring how sleep protects against neurodegeneration: Neuron cell.com/neuron/fulltext/S08…

The night’s watch: Exploring how sleep protects against neurodegeneration

Parhizkar and Holtzman discuss how sleep disturbances may serve as both an early indicator and potential driver of neurodegenerative diseases, particularly in Alzheimer’s, while reviewing mechanisms...

cell.com
9
13
927
Pupil size reveals arousal level fluctuations in human sleep nature.com/articles/s41467-0….
27
3
102
6,146
SleepLüthiLab retweeted
Neuron@NeuroCellPress19 Feb 2025
Here's our latest issue: cell.com/neuron/current The cover is for a Perspective piece by Lüthi & Nedergaard who discuss microarousals, and propose an inverted U-shaped relationship to reconcile their essential and disruptive roles: cell.com/neuron/fulltext/S08… Cover by Nadia Alzoubi
11
2
27
5,358
SleepLüthiLab retweeted
Yulong Li Lab@yulonglilab19 Jan 2025
Almost all neurons co-release peptides and small transmitters. Thrilled to share our latest research where new GRAB sensor promotes better understanding of the dynamics and molecular regulation between neuropeptide and neurotransmitter release in vivo. nature.com/articles/s41467-0…
5
61
3
267
24,036
It is an exciting time to be studying the functions of noradrenaline waves and micro-arousals in sleep 🧠💤 Take a look at this brand new review from @anita_luthi and Maiken Nedergaard on the subject
Anita Luthi@anita_luthi13 Jan 2025
Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key sleep functions: Neuron cell.com/neuron/fulltext/S08…

Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key...

Clinically, microarousals are mostly pathological sleep disruptions linked to health risks. Neurobiologically, microarousals support the roles of noradrenergic infraslow fluctuations in healthy mouse...

cell.com
4
26
1,326
SleepLüthiLab retweeted
Anita Luthi@anita_luthi13 Jan 2025
thetransmitter.org/sleep/fle…

Fleeting sleep interruptions may help brain reset

Brief, seconds-long microarousals during deep sleep “ride on the wave” of locus coeruleus activity in mice and correlate with periods of waste clearing and memory consolidation, new research suggests.

thetransmitter.org
2
8
546
SleepLüthiLab retweeted
Anita Luthi@anita_luthi14 Jan 2025
Maiken and I review here the brief awakenings from #sleep called #microarousals. They fragment sleep, but they are also integral to healthy sleep dynamics - so how to reconcile these opposing views? @LabLuthi @fbm-unil.bsky.social @anitaluthi.bsky.social
Neuron@NeuroCellPress14 Jan 2025
Online now: Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key sleep functions dlvr.it/THLG9T
5
8
1,227
SleepLüthiLab retweeted
Anita Luthi@anita_luthi9 Jan 2025
Check out the landmark study of @NedergaardLab on #infraslow #locus #coeruleus activity in #NREM #Sleep and the link to blood volume, cerebrospinal fluctuations - 👏@NatalieHauglund 👏 from @LabLuthi
Natalie Hauglund@NatalieHauglund8 Jan 2025
Out today in @CellCellPress ! We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 cell.com/cell/fulltext/S0092…

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic and pharmacological manipulati...

cell.com
4
18
844
Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM #sleep cycle @LabLuthi @anita_luthi @alejandrosoriof @GFoustoukos @CardisRomain nature.com/articles/s41593-0…

Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep...

Nature Neuroscience - Lüthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep....

nature.com
20
88
10,791
SleepLüthiLab retweeted
Anita Luthi@anita_luthi25 Nov 2024
Replying to @LabLuthi
@LabLuthi uncovers a dual role of #locus @coeruleus in #sleep -> 1) its strict gatekeeper role for the sleep cycle 2) the partial brain-body arousals it generates. Powerful minds behind all this: @alejandrosoriof @GFoustoukos @CardisRomain nature.com/articles/s41593-0…

Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep...

Nature Neuroscience - Lüthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep....

nature.com
12
48
5
134
11,742
👍@unil has noted a reduction in the number of animals 🐁used for research in 2023 compared with 2022. This is due in particular to increased efforts to integrate the 3Rs principle into all stages of the scientific process. news.unil.ch/display/1727451…
1
3
434
Load more