Maher Lab retweeted
Hand here’s the official reveal: part 2 of my almost joint PhD thesis with @apfenning and @wickedneuro co-led by the amazing @maddiehray. Check out what cross-primate conservation of single cell damage in OUD.
nature.com/articles/s41467-0…
Maher Lab retweeted
Want to be the first to find out about all things #PittHopkins?
We share important information about our conference, upcoming trials, research updates, and more via our email list!
JOIN THE PARENT LIST: pitthopkins.org/parent-e-mai…
JOIN THE GENERAL EMAIL LIST: pitthopkins.org/about-us/joi…
Maher Lab retweeted
We can't thank you enough for your support in 2023, which has been a year of growth for the PHRF!
facebook.com/photo/?fbid=774…
#PittHopkins #research #happynewyear24 #hope #raredisease
Maher Lab retweeted
Thank you @lajollalabs for this great blog summarizing #PittHopkins and for your work to move toward a treatment!
Read more Pitt-Hopkins syndrome and the lives of patients affected in our new blog post: genome.bio/post/tcf4-the-gen…
#PTHS #PittHopkinsSyndrome #PittHopkins #raredisease #rare #ultrarare #TCF4 #neuro #rareresearch #LJL #lajollalabs #RevealingRareGenes
Maher Lab retweeted
Don't miss learning about her amazing work!
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Maher Lab retweeted
Happy #SfN23! Catch Gina Shim's poster session "Investigating the impact of common genetic risk variants for schizophrenia on neuronal function elucidates relationships between cellular phenotypes, clinical status and cognitive performance" Sunday!
Maher Lab retweeted
I am beyond excited to share our new paper on massively parallel reporter assays on schizophrenia-associated variants. This is in collaboration with @jsteinlab, @srikosuri, @mikelove, @_josedavila, @brad_ruzicka, @AP_Boyle. 🧵 follows.
Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants dlvr.it/SwBgpY
Maher Lab retweeted
So thrilled to share this incredible work from @LabMaher at @LieberInstitute. Thank you @bradymaherPhD and team!
biologicalpsychiatryjournal.…
Maher Lab retweeted
Bohlen et al. show that promyelinating drugs reduce myelination defects and rescue behavioural and electrophysiological deficits in a mouse model of Pitt -Hopkins syndrome, an autism spectrum disorder caused by autosomal dominant mutations in TCF4. tinyurl.com/vbnmfs2e
Maher Lab retweeted
Yay 🎉🎉🎉! I'm so excited to be able to do science with such a supportive team! Thank you @LabMaher @bradymaherPhD and @MD_Stem_Cell 😊
Maher lab had some fun celebrating @ARomeroMorales postdoctoral fellowship funding by the @MD_Stem_Cell Congrats Ale!!!! mscrf.org/awardees
Maher Lab retweeted
Five U.S.-based transit systems have used autistic children’s voices to play their public service announcements during Autism Awareness Month.
Via @NPR.
n.pr/42jd3js
Maher Lab retweeted
The current issue of Science is out online with a lot of evolutionary genomics from zoonomiaproject.org and the @apfenning lab, a massive effort!
On mammals: science.org/doi/10.1126/scie…
On humans: science.org/doi/10.1126/scie…
On regulatory evolution: science.org/doi/10.1126/scie…
Maher Lab retweeted
"In this study, we demonstrate that pharmacological enhancement of myelination with clemastine or sobetirome/Sob-AM2 are beneficial rescue approaches in a" Pitt–Hopkins syndrome mouse model, the authors of a study in Brain write: bit.ly/3GWUjOR.
Maher Lab retweeted
Results from this study in @molpsychiatry begin to reveal how mutations in the autism-linked gene MYT1L lead to developmental delays and autism, says lead investigator @MoritzMall: bit.ly/3YQ6Km0.
By @LauraLauraDat.
@joeddoughert @bradymaherPhD
bit.ly/3YNtQcL
Maher Lab retweeted
Really please to share our @LabMaher recent preprint, where we use a 2D differentiation protocol developed by @UPenn_SongMing to achieve a transcriptional profile approximating dorsolateral prefrontal cortex in human late fetal-postnatal stages thanks to help from @andrewjaffe.
Maher Lab retweeted
At #ACNP2022, @LabMaher and Matt MacDonald chairing a session on understanding the biology of schizophrenia genetic risk. Leading off, @Fede_Farinelli describes ePhys studies showing altered excitability in iPSC-derived neurons.
Maher Lab retweeted
Need high quality AAV, lenti-, or rabies-virus for neuro applications? Look no further than the UNC Neuroscience Center and the BRAIN Initiative Viral Vector Core!!!
unc-neurotools.org/
@KimRitola @uncneuro
Maher Lab retweeted
CIRM has awarded a $4 million grant to Mahzi Therapeutics to support the work of developing a gene therapy treatment for #PittHopkins syndrome. Incredible news! cirm.ca.gov/our-progress/awa…