🧵/1 AI-driven discovery of GPNMB CAR T cells as a multi-cancer therapy @CellPressNews AI did not “invent” a CAR T therapy here. It helped focus the search for a plausible target in a very large haystack of public single-cell and expression data. That distinction matters. The important advance is human expertise plus AI triage, followed by wet lab validation. GPNMB CAR T activity across melanoma, leukemia, and colorectal models is intriguing. The hard human enabled part is demonstrating specificity, safety, clinical translation. @PennMedicine @daniel_baker_j @JonEpsteinLab @AranyLab @carlhjune