Proud moment to see/discuss my former trainees’ poster at KW! Great work Shintaro, Kana, and their grad student, Tetta! Check SA-PO151

Congrats, Sue!

We had a great time at @GordonConf on Cell Death last week! Meeting old friends, making new friends, and lots of discussions.

I visited my former thesis advisor Masi Yamamoto in Sendai today. So many cool Nrf2 studies are ongoing. Very nice reunion.

Congrats Shintaro on your excellent achievement! I am thrilled to know you are awarded YIA from the Japanese Society of Nephrology 😀

Myles Wolfラボポスドク募集中。相馬及び相馬ラボメンバーがセットアップから新しい技術の取得、キャリアアップに向けて丁寧に指導します。応募お待ちしています。

Cool image by Emily Burke in Grabner lab @Ascclepios @DukeKidney highlights our finding reported in @CellReports. Female resilience mechanisms can be therapeutically harnessed to improve kidney repair after AKI by inhibiting ferroptosis. cell.com/cell-reports/fullte…

Finally, pharmacological activation of NRF2 in male kidneys prevented ferroptosis as in females! We propose NRF2 in the proximal tubule is critical for renal repair by maintaining their #plasticity and inhibiting #ferroptosis.

Lineage tracing, genetic #NRF2 deletion, and pharmacological inhibition of #ferroptosis found NRF2 regulates proximal tubular cell fate, plasticity, and ferroptosis in vivo in the kidney.

Among the multiple candidate factors, we focused on #NRF2 as a potential mechanism for female resilience. #NRF2 activity is high in the female proximal tubule most likely due to a low testosterone environment.