Srinivas Research Group

Even our embryos are starting to feel a little festive in the Srinivas lab! We are happy to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo biorxiv.org/content/10.1101/…

Excited to share our paper out in @Dev_Cell today. A colab with Scialdone @anto_scial & @CellsigL labs. Study led by S Thowfeequ @ShifaanT & J Fiorentino–a molecular characterisation of one of the most important cell migration events during development. sciencedirect.com/science/ar…

We are happy to share our new bioR𝜒iv pre-print – a multidisciplinary imaging and computational approach to understanding collective cell migration in the early mouse embryo #scPhenomics #flocking biorxiv.org/cgi/content/shor…

2nd Crick-Beddington Developmental Biology Symposium. 7-8 Feb 2022, registration now open.

These data provide a spatial and molecular atlas of the developing heart that we hope you'll find useful! We have put together a website to explore the data, movies and results at marionilab.cruk.cam.ac.uk/he….

Lineage tracing and live-imaging studies revealed that the JCF could contribute to both cardiomyocytes and the proepicardium. Thus, the JCF represents the earliest progenitor of the epicardium.

Among these, we found a new progenitor pool, which we termed the Juxta-Cardiac Field (JCF), since it overlays the cardiac crescent but is distinct from the First Heart Field.

Using combinatorial whole-mount imaging we anatomically located these progenitor types over the course of heart formation.

We used single-cell RNA-seq to characterise cell subpopulations during cardiac crescent to early linear heart tube development. We identified several progenitor populations and their transition states towards cardiomyocytes.