@LaylaSiraj

Future Ob/Gyn, @HarvardMITmdphd w/ Eric Lander and Hilary Finucane @broadinstitute and @harvardGSAS Biophysics, exploring epigenetics & gene regulation

 Cambridge, MA
Joined July 2019
  • Tweets85
  • Following204
  • Followers352
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Layla Siraj, Ph.D. retweeted
Edlow Lab@EdlowLab15 Nov 2024
Edlow Labsgiving! So fun!🍗🦃🥧. And joined by our guest speaker and collaborator Kate Dannheim to talk about the placenta. very thankful for this group ❤️
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Layla Siraj, Ph.D. retweeted
Rodrigo I Castro@i_rodcast25 Oct 2024
Excited to share our sequence design work published in @Nature. I had the privilege of co-leading this effort alongside my friend and colleague @SagerGosai under the supervision of @r_tewhey, @ReillyLikesIt, and @PardisSabeti nature.com/articles/s41586-0… 1/7
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Layla Siraj, Ph.D. retweeted
Amir Siraj@TheAmirSiraj13 Sep 2024
Excited to speak and perform tonight at @SmithsonianNPG for Our Universe, Our Future, the kickoff of the @Smithsonian $2.5B Campaign For Our Shared Future in honor of our nation’s upcoming 250th anniversary!
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Layla Siraj, Ph.D. retweeted
Pardis Sabeti
@PardisSabeti3 Jul 2024
Thrilled to introduce Delphy for fast, accurate, scalable Bayesian #phylogenetics. Web: delphy.fathom.info Whitepaper: tinyurl.com/58n77vk5 & more to come! #patrickvarilly @sabeti_lab @fathominfo @acegid #sentinel Raw genomes -> results in minutes anywhere a thread 🧵1/14
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Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays! biorxiv.org/content/10.1101/… See below for a 🧵. 1/n

Functional dissection of complex and molecular trait variants at single nucleotide resolution

Identifying the causal variants and mechanisms that drive complex traits and diseases remains a core problem in human genetics. The majority of these variants have individually weak effects and lie...

biorxiv.org
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As part of @ENCODE_NIH, we now test a whopping 39K likely causal variants (posterior probability > 0.5) and 89K distinct signals (credible sets) in MPRA across 5 diverse cell types. 3/n
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We find a total of 37K expression-modulating variants (emVars) with allelic differences in transcription. Building on previous work from @jraylab, we show that emVars from annotated cis-regulatory elements (CREs) capture likely causal variants with high precision. 4/n
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Layla Siraj, Ph.D. retweeted
Princeton University
@Princeton5 Jan 2024
A new study from #PrincetonU's @TheAmirSiraj shows that there may be rogue planets the size of Mars existing in the outer solar system, captured by our sun's gravity long ago. bit.ly/47toKpX (via @physorg_com)
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Layla Siraj, Ph.D. retweeted
The Nobel Prize
@NobelPrize9 Oct 2023
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2023 Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel to Claudia Goldin “for having advanced our understanding of women’s labour market outcomes.” #NobelPrize
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Layla Siraj, Ph.D. retweeted
The Nobel Prize
@NobelPrize9 Oct 2023
Historically, much of the gender gap in earnings could be explained by differences in education and occupational choices. However, this year’s economic sciences laureate Claudia Goldin has shown that the bulk of this earnings difference is now between men and women in the same occupation, and that it largely arises with the birth of the first child. #NobelPrize
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Layla Siraj, Ph.D. retweeted
The Nobel Prize
@NobelPrize2 Oct 2023
BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
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Layla Siraj, Ph.D. retweeted
Pardis Sabeti
@PardisSabeti17 Sep 2023
#Mahsaamini your light shines bright ✨
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Layla Siraj, Ph.D. retweeted
Sager Gosai@SagerGosai10 Aug 2023
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.1101/… 1/n

Machine-guided design of synthetic cell type-specific cis-regulatory elements

Cis -regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing, and stimulus responses, which collectively define the thousands of unique cell types in...

biorxiv.org
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Layla Siraj, Ph.D. retweeted
Marc-André Hamelin@MarcAndreHam7 Jul 2023
And I am proud to say I had the pleasure of teaching him!
New England Conservatory@necmusic6 Jul 2023
Replying to @necmusic
"I got the chance to play at the site of the first interstellar meteor," Amir said. He is fascinated by the intersection of astrophysics and music. He performed Liszt's Funérailles "in honor of the meteor's journey, which lasted somewhere between millions and billions of years."
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Layla Siraj, Ph.D. retweeted
Princeton University
@Princeton7 Jul 2023
After years of effort, says #PrincetonU's @TheAmirSiraj, researchers may have found pieces of IM1, "a kitchen sink-sized chunk of interstellar material" that they believe collided with Earth in 2014. More on the discovery at @sciam ⬇️ bit.ly/46xyOzf
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Layla Siraj, Ph.D. retweeted
Amir Siraj@TheAmirSiraj12 Apr 2022
Here’s the ~short version~ of the three-year-long saga that resulted in the confirmation of the first interstellar meteor! @sciam scientificamerican.com/artic…

Spy Satellites Confirmed Our Discovery of the First Meteor from beyond the Solar System

A high-speed fireball that struck Earth in 2014 looked to be interstellar in origin, but verifying this extraordinary claim required extraordinary cooperation from secretive defense programs

scientificamerican.com
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Layla Siraj, Ph.D. retweeted
Amir Siraj@TheAmirSiraj5 Jul 2023
We’re back from the Pacific ocean! Check out the details in my commentary for @sciam
Scientific American
@sciam5 Jul 2023
Tiny spheres of once-molten metal magnetically dredged from the seafloor could be pieces from IM1, a potential interstellar meteor that struck Earth in 2014 trib.al/fV6NCeN

Have We Found Fragments of a Meteor from Another Star?

Tiny spheres of once-molten metal magnetically dredged from the seafloor could be pieces from IM1, a potential interstellar meteor that struck Earth in 2014

scientificamerican.com
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So proud of @HarvardMITmdphd student @LaylaSiraj for her successful thesis defense entitled, “Characterizing Regulatory Elements and Non-Coding Variants in The Human Genome.” And kudos to mentors @eric_lander and Hilary Finucane! Amazing work! @HarvardGSAS
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Layla Siraj, Ph.D. retweeted
Harvard University
@Harvard27 May 2023
Relive the excitement of Commencement 2023! #Harvard23

Celebrating the Class of 2023

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