Pathologist 🇨🇵 Fellowship in #ENTpath and #BSTpath 2021-2023 at @CHUnantes 🔬 PhD student ⚗️Co-community manager of @Annpathol. #Pathology #AI
Paris, France
Joined September 2018
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Charles Lépine, MD retweeted
As many of you now may be aware, Dr. Chris Fletcher recently passed away. His contributions to the field of ST pathology (and my career) are immeasurable. Interestingly, once I decided in 1993 to develop expertise in #BSTpath, my question was where (or with whom) would I train?
Charles Lépine, MD retweeted
CD28 co-stimulation: novel insights and applications in cancer immunotherapy dlvr.it/TB4Ksg
Charles Lépine, MD retweeted
Identification 🤓of Resistance Biomarkers to HER2 Inhibitors: Advances and Challenges in HER2+ Breast Cancer
🔴Therapeutic advances: HER2 inhibitors have significantly improved the treatment of HER2+ breast cancer.
🟢Persistent challenge: Resistance to these drugs remains a critical issue.
🔵Key biomarkers identified: Mutations in the ERBB2 gene, activation of alternative signaling pathways, expression of estrogen receptors, and alterations in regulatory protein levels have been found.
🟡New explorations: More effective regimens and promising combination therapies are being investigated.
🌟This review highlights current HER2-targeted therapies, analyzes predictive biomarkers of drug resistance, and presents emerging therapies, especially combination treatments, aimed at overcoming resistance in the context of HER2+ breast cancer. @OncoAlert @BCTrials @BCTrials @DraMartinezLago @Dra_Kleine
mdpi.com/2072-6694/16/15/263…
Charles Lépine, MD retweeted
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Charles Lépine, MD retweeted
We're excited to announce our $15M Series A led by @foundersfund to build the Metalayer, the end game for Ethereum rollups 🌋
This round brings our total funding to $25M and will help us advance our goal of making Ethereum go web-scale.
Charles Lépine, MD retweeted
❌GCT of bone: adults, oval mononuclear cells (not spindled like NOF), giant cell nuclei ~ mononuclear cell nuclei that are (+) H3.3 G34W
❌ Fibrous dysplasia: well-demarcated ground glass lesion; irregular trabeculae in background of bland spindle cells
✅Non-ossifying fibroma: kids, metadiaphyseal lobulated lesion with sclerotic rim; bland storiforming fibroblasts, interspersed osteoclast-like multinucleated giant cells
#PediPath #BSTPath #PathTwitter #Pathology
Charles Lépine, MD retweeted
Bone lesion. Your diagnosis? Answer here: kikoxp.com/posts/4499 @smlungpathguy @Radiopaedia #BSTpath #radpathmatch #radiology #sarcoma #pathologists #pathology #pathTwitter
Charles Lépine, MD retweeted
Clear cell metaplasia in a sigmoid polyp from my colleague @edinpath. Resembles secretory endometrium and perhaps Sertoli cells! No clinical importance but pretty! Nice review by Dabir, van der Post & Nagtegaal. Histopathology, 2021. 78: 348-357 #GIpath #Pathologists @pathkids – at Porthtowan, England
Charles Lépine, MD retweeted
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Charles Lépine, MD retweeted
Excellent symposium SFCC/SFP glandes salivaires Carrefour Pathologie 2023 #Milan2 classification OMS Apport de la bio mol
Charles Lépine Valérie Costes-Martineau Claude Bigorgne Emmanuelle Uro-Coste 👏🏻👍🏻
Charles Lépine, MD retweeted
🔬 La Société Française de Pathologie et les Annales de Pathologie s'associent pour l'édition 2023 du concours photo 📸
⏳ Vous avez jusqu'au 1e octobre pour y participer!
👉 Toutes les infos sont ici buff.ly/3D0qBGa
#pathart #pathology #francophonepath
@SFPathol
Charles Lépine, MD retweeted
And finally Case N°3, a classic in #BSTPath #DermPath with this I wish you a great WeekEnd! @PoloniaAntonio @DrBMcGinn @NeoCrazee @sumeyra_md @caseypschukow @LepinePathol @rehdam @ZKrikic @nusrat_xahra @Kashifhazim @goziemnweke @Venkateshgilly2 #pathology #PathTwitter
Charles Lépine, MD retweeted
Let's go to case N°2, here the IHC to guess is expressed only focally @PoloniaAntonio @DrBMcGinn @NeoCrazee @sumeyra_md @caseypschukow @LepinePathol @rehdam @ZKrikic @nusrat_xahra @Kashifhazim @goziemnweke @Venkateshgilly2 @DrBonita16 #pathology #PathTwitter #BSTPath
Charles Lépine, MD retweeted
Three different #BSTPath entities and the same IHC marker, are you able to tell me which diagnoses and which shared IHC? @PoloniaAntonio @DrBMcGinn @NeoCrazee @sumeyra_md @caseypschukow @LepinePathol @rehdam @ZKrikic @nusrat_xahra @Kashifhazim @goziemnweke #PathTwitter
Case N°1:
Charles Lépine, MD retweeted
A special #BSTPath hat trick, same IHC but different diagnoses, N°1: old F, trunk dermal lesion, your thoughts? @PoloniaAntonio @SumantaDas_7 @sumeyra_md @NeoCrazee @rehdam @DrGeeONE @seyma_buyucek @LepinePathol @LuizMiguelN @DrNishatAfroz2 @Greg_Charville @DrBMcGinn #PathTwitter
Charles Lépine, MD retweeted
Two 'hot' #BSTPath cases to warm up your weekend! N°1: 45yF, thigh mass, deep located. Your differentials? Any IHCs? @PoloniaAntonio @caseypschukow @SumantaDas_7 @LoboAnandi @Romanow_MD @shahidi_hossein @DrGeeONE @NeoCrazee @sumeyra_md @DrNishatAfroz2 #PathTwitter #pathresidents
Charles Lépine, MD retweeted
Quand une interne en gynécologie fait des interviews 🦸🏻♀️ bravo Yousrah ☀️ et merci de mettre en lumière le métier d’anatomo-pathologie podcast.ausha.co/derriere-l-… @VerkarreVirgin2 @A_Morini_MD @LepinePathol @ChloeBrdn
