In contrast, PGC-like cells (PGCLCs) contribute to mid-gestation chimaeras. This indicates that naive pluripotency is more accessible in PGCLCs than with their in vivo counterparts.

Even though apoptosis-deficient PGCs can acquire naive pluripotency in vitro, they do not functionally contribute to post-implantation development.

PGC-ESCs are naive pluripotent stem cells transcriptionally similar to ESCs and able to contribute towards live chimaeras with germline transmission.

Apoptosis-deficient PGCs acquire morphological characteristics of naive pluripotency and ICM outgrowths can be expanded and newly derived ESCs can be established. PGC-ESCs are morphologically indistinguishable from host ESCs.

We injected migratory PGCs (E8.5-E9.5) into 8-cell stage embryos. Injected PGCs can survive, proliferate, and integrate within the host inner cell mass. PGCs are identify by Oct4ΔPE-GFP reporter.

2024 let the soul dance and the heart sing!

@GunesTaylor training finally started!!! slowly but surely ☺️

Enjoying some beautiful embryo #MicroCT imaging 😍 @MRC_LMS

Always a sunseeker!

envious people would say it's not snowing in Australia! here is the proof!!!